[1]王慧 张燕平 王志强 陈桂华 谢江.基于孟德尔随机化探索肠道菌群与儿童川崎病之间的因果关系[J].心血管病学进展,2023,(6):572.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.020]
 WANG HuiZHANG Yanping,WANG Zhiqiang,CHEN Guihua,et al.To Explore the Causal Relationship Between Gut Microbiota and Kawasaki Disease in Children Based on Mendelian Randomization[J].Advances in Cardiovascular Diseases,2023,(6):572.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.020]
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基于孟德尔随机化探索肠道菌群与儿童川崎病之间的因果关系()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年6期
页码:
572
栏目:
论著
出版日期:
2023-06-25

文章信息/Info

Title:
To Explore the Causal Relationship Between Gut Microbiota and Kawasaki Disease in Children Based on Mendelian Randomization
作者:
王慧 张燕平 王志强 陈桂华 谢江
(西南交通大学附属医院 成都市第三人民医院儿科,四川 成都 610031)
Author(s):
WANG HuiZHANG YanpingWANG ZhiqiangCHEN GuihuaXIE Jiang
(The Affiliated Hospital of Southwest Jiaotong University,Department of Pediatrics,The Third People’s Hospital of Chengdu,Chengdu 610031,China)
关键词:
肠道菌群川崎病放线菌孟德尔随机化
Keywords:
Gut microbiotaKawasaki diseaseAdlercreutziaActinomycetesMendelian randomization
DOI:
10.16806/j.cnki.issn.1004-3934.2023.06.020
摘要:
目的 利用孟德尔随机化研究方法验证肠道菌群与川崎病之间是否存在因果关系。方法 使用MiBioGen联合会收集的18 340例来自24个队列的基因数据,选取31个影响微生物分类群相对丰度或存在的遗传变异作为工具变量。从波兰一项有关儿童川崎病易感基因的全基因组关联中提取与川崎病关联的结果,通过逆方差加权法(IVW)、加权中位数法和MR-Egger回归法分别判断肠道菌群与川崎病的因果关联。绘制工具变量相关的肠道菌群与川崎病风险的森林图及散点图。结果 共筛选到7个与肠道菌群相关的作为工具变量,IVW结果显示安德克氏菌属川崎病有关(OR=0.222,95% CI 0.052~0.940,P=0.041),提示安德克氏菌属丰度每增加一个标准差,川崎病的发病风险平均减少77.8%。结论 分析显示安德克氏菌属丰度与川崎病发病风险呈负向因果效应。
Abstract:
Objective To verify whether there is a causal relationship between gut microbiota and Kawasaki disease using Mendelian randomization(MR) method. Methods Genetic data of 18340 individuals from 24 cohorts were collected by MiBioGen consortium. Genetic variants affecting the relative abundance or presence of microbial taxa were selected as instrumental variables. The results of association with Kawasaki disease were extracted from a GWAS study of susceptibility genes of children with Kawasaki disease in Poland. Inverse variance weighted analysis,weighted median method and MR-Egger regression method were used to determine the causal association between gut microbiota and Kawasaki disease. Forest plots and scatter plots of the association between gut microbiota and the risk of Kawasaki disease were drawn. Results A total of 6 SNP associated with gut microbiota were screened,IVW analysis:OR=0.222,95% CI 0.052~0.940,P=0.041.IVW results of forest plots showed that the abundance of Adlercreutzia was related to Kawasaki diseasea 1 s increase in the abundance of Adlercreutzia,and the risk of suffering from Kawasaki disease reduced by an average of 77.8%(OR=0.222,95% CI 0.052~0.940). Conclusion Mendelian randomization analysis IVW method showed that the abundance of Adlercreutzia had a negative causal effect on the risk of Kawasaki disease

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更新日期/Last Update: 2023-07-21