[1]赵池 王明烨 崔雯雯 李彤彤 郝媛媛 宋涛 侯云龙.心房利尿钠肽在心力衰竭治疗中的研究进展[J].心血管病学进展,2022,(12):1109.[doi:10.16806/j.cnki.issn.1004-3934.2022.12.012]
 ZHAO Chi,WANG Mingye,LI Tongtong,et al.Atrial Natriuretic Peptide in Treatment of Heart Failure[J].Advances in Cardiovascular Diseases,2022,(12):1109.[doi:10.16806/j.cnki.issn.1004-3934.2022.12.012]
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心房利尿钠肽在心力衰竭治疗中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年12期
页码:
1109
栏目:
综述
出版日期:
2022-12-25

文章信息/Info

Title:
Atrial Natriuretic Peptide in Treatment of Heart Failure
作者:
赵池 王明烨 2 崔雯雯 2 李彤彤 2 郝媛媛 2 宋涛 2 侯云龙 1234
(河北医科大学研究生院,河北 石家庄 050017;2.河北中医学院中西医结合学院,河北 石家庄 050200;3.石家庄市复方中药技术创新中心,河北 石家庄 050035;4.络病研究与创新中药国家重点实验室,河北 石家庄 050035)
Author(s):
ZHAO Chi1 WANG Mingye2 LI Tongtong2 HAO Yuanyuan2 SONG Tao 2 HOU Yunlong1234
(1.Institute of Graduate, Hebei Medical University,Shijiazhuang 050017,Hebei,China; 2.College of Integrated Traditional Chinese and Western Medicine,Hebei Medical University of Chinese Medicine,Shijiazhuang 050200,Hebei,China; 3.Shijiazhuang Compound Traditional Chinese Medicine Technology Innovation Center,Shijiazhuang 050035,Hebei,China; 4.National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine,Shijiazhuang 050035,Hebei,China)
关键词:
心房利尿钠肽心力衰竭治疗方法
Keywords:
Atrial natriuretic peptide Heart failure Therapies
DOI:
10.16806/j.cnki.issn.1004-3934.2022.12.012
摘要:
心力衰竭是由于各种心血管疾病引起一系列病理生理的改变,使心脏的收缩和舒张功能障碍并引起心脏泵血功能受损所导致的临床综合征。心力衰竭发生时,人体各个器官的血流量降低导致呼吸困难、出汗、咳嗽、头晕乏力、烦躁等症状,给患者带来了极大的痛苦和负担。心房利尿钠肽(ANP)是一种心脏激素,可通过利尿利钠调节水盐平衡。ANP在心力衰竭的治疗中具有独特性,可从多方面缓解心力衰竭。因此,此文对ANP进行了系统概括,并阐述了ANP在心力衰竭中发挥的作用及ANP相关药物的在心力衰竭治疗中的临床应用情况。希望可通过此文提升人们对ANP和心力衰竭的认识,并为临床治疗心力衰竭提供一定的借鉴意义。
Abstract:
A series of pathophysiological changes caused by various cardiovascular diseases lead to cardiac systolic and diastolic dysfunction and impaired cardiac pumping function. The clinical syndrome is called heart failure. When heart failure occurs,the decrease of blood flow in various organs of the human body leads to dyspnea,sweating,cough,dizziness,irritability and other symptoms,which bring great pain and burden to patients. The atrial natriuretic peptide (ANP) is a cardiac hormone that can regulate water-salt balance through diuretic sodium. The ANP is unique in the treatment of heart failure ,which can alleviate heart failure in many ways. Therefore,this paper systematically summarizes ANP and expounds on the role of ANP in heart failure and the clinical application of ANP-related drugs in the treatment of heart failure. It is hoped that this article can improve people’s understanding of ANP and heart failure ,and provide some reference for clinical treatment of heart failure

参考文献/References:

[1].Gronda E,Jessup M,Iacoviello M,et al. Glucose metabolism in the kidney:neurohormonal activation and heart failure development[J]. J Am Heart Assoc,2020,9(23):e018889.
[2].国家心血管病中心.《中国心血管健康与疾病报告》2020[J]. 心肺血管病杂志,2021,40(10):1005-1009.
[3].Berliner D,Bauersachs J. Current drug therapy in chronic heart failure:the new guidelines of the European Society of Cardiology (ESC)[J]. Korean Circ J, 2017,47(5):543-554.
[4].Tsutsui H,Isobe M,Ito H,et al. JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure—Digest Version[J]. Circ J 2019,83(10):2084-2184.
[5].Go AS,Mozaffarian D,Roger VL,et al. Heart disease and stroke statistics--2014 update:a report from the American Heart Association[J]. Circulation,2014,129(3):e28-e292.
[6].Nishikimi T,Maeda N,Matsuoka H. The role of natriuretic peptides in cardioprotection[J]. Cardiovasc Res,2006,69(2):318-328.
[7].de Bold AJ,Borenstein HB,Veress AT,et al. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats[J]. Life Sci,1981,28(1):89-94.
[8].Newton-Cheh C,Larson MG,Vasan RS,et al. Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure[J]. Nat Genet,2009,41(3):348-353.
[9].Gupta DK,Wang TJ. Natriuretic peptides and cardiometabolic health[J]. Circ J,2015,79(8):1647-1655.
[10].Somanna NK,Yariswamy M,Garagliano JM,et al. Aldosterone-induced cardiomyocyte growth,and fibroblast migration and proliferation are mediated by TRAF3IP2[J]. Cell Signal,2015,27(10):1928-1938.
[11].Fujita S,Shimojo N,Terasaki F,et al. Atrial natriuretic peptide exerts protective action against angiotensin II-induced cardiac remodeling by attenuating inflammation via endothelin-1/endothelin receptor A cascade[J]. Heart Vessels,2013,28(5):646-657.
[12].Abassi Z,Karram T,Ellaham S,et al. Implications of the natriuretic peptide system in the pathogenesis of heart failure:diagnostic and therapeutic importance[J]. Pharmacol Ther,2004,102(3):223-241.
[13].谭令,付长庚,龙霖梓,等. 利钠肽检测在心力衰竭中的应用价值[J]. 医学综述 2021,27(24):4875-4882.
[14].Bae EH,Ma SK,Lee J,et al. Altered regulation of renal nitric oxide and atrial natriuretic peptide systems in angiotensin II-induced hypertension[J]. Regul Pept,2011,170(1-3):31-37.
[15].Potter LR,Abbey-Hosch S,Dickey DM. Natriuretic peptides,their receptors,and cyclic guanosine monophosphate-dependent signaling functions[J]. Endocr Rev,2006,27(1):47-72.
[16].Clemmer JS,Pruett WA,Hester RL,et al. Preeminent role of the cardiorenal axis in the antihypertensive response to an arteriovenous fistula:an in silico analysis[J]. Am J Physiol Heart Circ Physiol,2019,317(5):H1002-H1012.
[17].van Tassell BW,Seropian IM,Toldo S,et al. Interleukin-1β induces a reversible cardiomyopathy in the mouse[J]. Inflamm Res,2013,62(7):637-640.
[18].Buckley LF,Abbate A. Interleukin-1 blockade in cardiovascular diseases:a clinical update[J]. Eur Heart J,2018,39(22):2063-2069.
[19].Van Tassell BW,Arena RA,Toldo S,et al. Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure[J]. PLoS One,2012,7(3):e33438.
[20].Francis GS,Bartos JA,Adatya S. Inotropes[J]. J Am Coll Cardiol,2014,63(20):2069-2078.
[21].Sager HB,Heidt T,Hulsmans M,et al. Targeting interleukin-1β reduces leukocyte production after acute myocardial infarction[J]. Circulation,2015,132(20):1880-1890.
[22].Kiemer AK,Vollmar AM. The atrial natriuretic peptide regulates the production of inflammatory mediators in macrophages[J]. Ann Rheum Dis,2001,60(Suppl 3):iii68-iii70.
[23].Zhang W, Chancey AL, Tzeng HP,et al. The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions[J]. Circulation ,2011,124(19): 2106-2116.
[24].Higuchi Y,McTiernan CF,Frye CB,et al. Tumor necrosis factor receptors 1 and 2 differentially regulate survival,cardiac dysfunction,and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy[J]. Circulation,2004,109(15):1892-1897.
[25].Saito Y,Nakao K,Itoh H,et al. Brain natriuretic peptide is a novel cardiac hormone[J]. Biochem Biophys Res Commun 1989,158(2):360-368.
[26].Saito Y. Roles of atrial natriuretic peptide and its therapeutic use[J]. J Cardiol,2010,56(3):262-270.
[27].Hata N,Seino Y,Tsutamoto T,et al. Effects of carperitide on the long-term prognosis of patients with acute decompensated chronic heart failure:the PROTECT multicenter randomized controlled study[J]. Circ J,2008,72(11):1787-1793.
[28].Ambwani J,Ubhrani D,Saad R,et al. Could atrial natriuretic peptide be a useful drug therapy for high-risk patients after cardiac surgery[J]? Interact Cardiovasc Thorac Surg,2009,8(4):474-478.
[29].Mitaka C,Kudo T,Jibiki M,et al. Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair[J]. Crit Care Med,2008,36(3):745-751.
[30].Potter LR. Natriuretic peptide metabolism,clearance and degradation[J]. FEBS J,2011,278(11):1808-1817.
[31].Feygina EE,Katrukha AG,Semenov AG. Neutral endopeptidase (neprilysin) in therapy and diagnostics:Yin and Yang[J]. Biochemistry (Mosc),2019,84(11):1346-1358.
[32].Mills J,Vardeny O. The role of neprilysin inhibitors in cardiovascular disease[J]. Curr Heart Fail Rep,2015,12(6):389-394.
[33].Chen Y,Burnett JC Jr. Biochemistry,therapeutics,and biomarker implications of neprilysin in cardiorenal disease[J]. Clin Chem,2017,63(1):108-115.
[34].McMurray JJ,Packer M,Desai AS,et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure[J]. N Engl J Med 2014,371(11):993-1004.
[35].Velazquez EJ,Morrow DA,DeVore AD,et al. Angiotensin-neprilysin inhibition in acute decompensated heart failure[J]. N Engl J Med,2019,380(6):539-548.
[36].Nougué H,Pezel T,Picard F,et al. Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure:a mechanistic clinical study[J]. Eur J Heart Fail,2019,21(5):598-605.
[37].Ibrahim NE,McCarthy CP,Shrestha S,et al. Effect of neprilysin inhibition on various?natriuretic peptide assays[J]. J Am Coll Cardiol,2019,73(11):1273-1284.
[38].Wang TD,Tan RS,Lee HY,et al. Effects of sacubitril/valsartan (LCZ696) on natriuresis,diuresis,blood pressures,and NT-proBNP in salt-sensitive hypertension[J]. Hypertension,2017,69(1):32-41.
[39].Seferovic JP,Claggett B,Seidelmann SB,et al. Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes:a post-hoc analysis from the PARADIGM-HF trial[J]. Lancet Diabetes Endocrinol,2017,5(5):333-340.
[40].Jordan J,Stinkens R,Jax T,et al. Improved insulin sensitivity with angiotensin receptor neprilysin inhibition in individuals with obesity and hypertension[J]. Clin Pharmacol Ther 2017,101(2):254-263.

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更新日期/Last Update: 2023-02-03