[1]王平 项涛 罗丽 孙玉芳 陈小红 张济梅 黄永平 张碧花.脓毒症与心力衰竭:两样本孟德尔随机化研究[J].心血管病学进展,2022,(8):759-762.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.022]
 WANG Ping,XIANG Tao,LUO Li,et al.Sepsis and Heart Failure: A Two-Sample Mendelian Randomization Study[J].Advances in Cardiovascular Diseases,2022,(8):759-762.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.022]
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脓毒症与心力衰竭:两样本孟德尔随机化研究(/HTML)
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年8期
页码:
759-762
栏目:
论著
出版日期:
2022-08-25

文章信息/Info

Title:
Sepsis and Heart Failure: A Two-Sample Mendelian Randomization Study
作者:
王平 项涛 罗丽 孙玉芳 陈小红 张济梅 黄永平 张碧花
(成都市第三人民医院急诊科,四川 成都 610031)
Author(s):
WANG PingXIANG TaoLUO LiSUN YufangCHEN XiaohongZHANG JimeiHUANG YongpingZHANG Bihua
(Department of Emergency,The third People’s of Hospital Chengdu,Chengdu 610031, Sichuan,China)
关键词:
脓毒症心力衰竭孟德尔随机化研究
Keywords:
Sepsis Heart failure Mendelian randomization analysis
DOI:
10.16806/j.cnki.issn.1004-3934.2022.08.022
摘要:
目的 观察性研究提示脓毒症与心力衰竭关系密切,但由于受到各种混杂因素的影响,导致它们之间的关系仍不确定。因此,笔者使用双样本孟德尔随机化(MR)来探索脓毒症与心力衰竭风险之间的因果关系。方法 本研究从两项最广泛的全基因组关联研究中获得了脓毒症和心力衰竭的汇总统计数据。为了使结果更加稳健和可靠,使用了几种稳健的分析方法(逆方差加权、MR-Egger回归、MR-PRESSO、最大似然比、简单中位数和加权中位数)进行了补充分析。此外,本研究采用MR-Egger截距检验、Cochran’s Q检验、漏斗图和“留一法”等对上述纳入的遗传变异工具变量的多效性和异质性水平进行评估。结果 笔者发现,脓毒症可能会增加心力衰竭发生的相对风险(OR=1.684,95%CI 1.587~1.786,P=0.001),而上述关系同样在加权中位数(OR=1.726,95%CI 1.585~1.881,P=0.001),MR-Egger回归(OR=1.768,95%CI 1.508~2.075,P=0.001),最大似然比(OR=1.686,95%CI 1.607~1.769,P=0.001),MR-PRESSO(OR=1.691,95%CI 1.590 ~1.799,P=0.001)中被证实。其次,MR-Egger截距检测(P=0.516)和检验显示,上述所纳入的遗传变异工具变量并不存在任何多效性。结论 脓毒症和心力衰竭发生的相对风险之间可能存在因果关系。
Abstract:
Objective Previous observational studies have indicated that sepsis may contribute to heart failure. However,with the limitation of reverse causality and confounder in observational studies,such relationship remains unclear. This study aims to reveal the causal effect of sepsis on heart failure. Methods This study collected summary statistics regarding sepsis,heart failure. Two-sample Mendelian randomization analysis was performed using MR Egger,inverse variance weighted,MR-PRESSO,maximum likelihood,and weighted median. Results We found that sepsis increased the relative risk of incident heart failure (OR=1.684,95% CI 1.587 ~1.786,P=0.001),and the association was similarly confirmed in the Weighted median (OR=1.726,95% CI 1.585~1.881), MR-Egger (OR=1.768, 95%CI 1.508~2.075,P=0.001), maximum likelihood(OR=1.686, 95%CI 1.607~1.769, P=0.001), and MR-PRESSO ( OR=1.691, 95% CI 1.590 ~1.799,P=0.001). Second, the MR Egger intercept test ( P=0.516) and the test showed that none of the instrumental variables of genetic variation included above had any pleiotropy. Conclusion This study provides new evidence of the relationship between sepsis and heart failure.

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备注/Memo

备注/Memo:
基金项目:成都市重点研发支撑项目(2021-yf05-00823-SN)
通信作者:王平,E-mail:wangping840523@163.com
更新日期/Last Update: 2022-10-08