[1]高源 郑刚 李嫣红 张鼎.维利西呱治疗心力衰竭新进展[J].心血管病学进展,2021,(8):698-701.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.007]
 Gao Yuan Zheng Gang Li Yan Hong Zhang Ding.Treatment of Heart Failure with Vericiguat[J].Advances in Cardiovascular Diseases,2021,(8):698-701.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.007]
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维利西呱治疗心力衰竭新进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年8期
页码:
698-701
栏目:
综述
出版日期:
2021-08-25

文章信息/Info

Title:
Treatment of Heart Failure with Vericiguat
作者:
高源1 郑刚1 李嫣红2 张鼎2
(1.陕西中医药大学,陕西 咸阳 7120462.陕西中医药大学附属医院心血管科,陕西 咸阳 712046)
Author(s):
Gao Yuan1 Zheng Gang1 Li Yan Hong2 Zhang Ding2
(1.Shaanxi University ofTraditional Chinese Medicine,Xianyang 712046,Shaanxi,China2.Department of Cardiology,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China)
关键词:
维利西呱心力衰竭可溶性鸟苷酸环化酶环磷酸鸟苷
Keywords:
VericiguatHeart failureSoluble guanylate cyclaseCyclic guanosine monophosphate
DOI:
10.16806/j.cnki.issn.1004-3934.2021.08.007
摘要:
心力衰竭是一种严重的临床综合征,其死亡率和再入院率较高。虽然传统的药物干预措施延缓了心力衰竭病程进一步恶化,改善了临床症状,但仍有一些患者的生活质量及预后较差。新型口服可溶性鸟苷酸环化酶刺激剂维利西呱,用于治疗慢性心力衰竭和射血分数降低的患者。该药患者耐受性较好,具有很好的安全性,值得临床应用推广。现综述NO-sGC-cGMP信号通路与心力衰竭的关系,维利西呱药理作用机制、临床治疗研究及药物安全性做一详细阐述为后期临床应用参考。
Abstract:
Heart failure is a serious clinical syndrome with high mortality and readmission rate. Although traditional drug intervention has delayed the further deterioration of heart failure and improved clinical symptoms,there are still some patients with poor quality of life and prognosis. A new oral soluble guanosine cyclase stimulator vericiguat is used in the treatment of patients with chronic heart failure and decreased left ventricular ejection fraction. This drug is well tolerated and safe,so it is worthy of clinical application and promotion. Therefore,this paper reviews the relationship between NO-sGC-cGMP signal pathway and heart failure,the pharmacological mechanism,clinical treatment research and drug safety of vericiguat for later clinical application reference.

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备注/Memo

备注/Memo:
第一作者:高源,陕西中医药大学附属第一医院心血管科 通信作者:郑刚,E-mail:zhenggang2283@163.com 收稿日期:2020-11-01
更新日期/Last Update: 2021-09-26