[1]李晨瑜 叶强.扩张型心肌病致病基因的研究进展[J].心血管病学进展,2021,(3):220-223，227.[doi:10.16806/j.cnki.issn.1004-3934.2021.03.007]
　LI Chengyu,YE Qiang.Pathogenic Genes of Dilated Cardiomyopathy[J].Advances in Cardiovascular Diseases,2021,(3):220-223，227.[doi:10.16806/j.cnki.issn.1004-3934.2021.03.007]
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扩张型心肌病致病基因的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年3期
页码:
220-223，227
栏目:
出版日期:
2021-03-25

文章信息/Info

Title:
Pathogenic Genes of Dilated Cardiomyopathy
作者:
李晨瑜1 叶强2
(1.西南医科大学临床医学四川 泸州 646000;西南医科大学附属医院心血管内科,四川 泸646000)
Author(s):
LI Chengyu1; YE Qiang1; 2
(1.Clinical Medical School of Southwest Medical University,Luzhou 646000,SichuanChina2.Department of Cardiology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,SichuanChina)
关键词:
扩张心肌病; 致病基因
Keywords:
Dilated cardiomyopathyPathogenic gene; Genetic therapy
DOI:
10.16806/j.cnki.issn.1004-3934.2021.03.007
摘要:
扩张心肌病是一组病因未明的心肌疾病，以左心室或双心室扩大伴收缩功能障碍为主要特征患者预后差，死亡率高，5年生存率约50%。近年来DCM发病率呈逐年上升趋势，早期诊断对改善患者预后十分重要。研究发现DCM的发病与基因相关，因此研究者提出通过筛选易感基因对早期DCM进行干预治疗。就近年来DCM致病基因和基因治疗的研究做简要综述。
Abstract:
Dilated cardiomyopathy（DCM）is a group of myocardial diseases with unknown etiology,characterized by left or biventricular dilation with systolic dysfunction. The prognosis of th patients is poor,and the mortality is high and the five-year survival rate is about 50%. In recent years,the incidence rate of DCM is increasing. It is necessary to strengthen the early diagnosis and treatment of DCM. Many studies have found that the pathogenesis of DCM is related to genes. Researchers proposed screening the susceptible genes to intervene the treatment of early DCM. The researches of pathogenic genes and gene therapy of DCM in recent years are reviewed in this paper.

参考文献/References:

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更新日期/Last Update: 2021-05-27