[1]王艳,综述,石蓓,等.心脏干细胞修复梗死心肌作用机制的研究进展[J].心血管病学进展,2016,(3):315-318.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.027]
 WANG Yan,SHI Bei.Research Progress of Cardiac Stem Cells Repairing Infarction Myocardial Function Mechanism[J].Advances in Cardiovascular Diseases,2016,(3):315-318.[doi:10.16806/j.cnki.issn.1004-3934.2016.03.027]
点击复制

心脏干细胞修复梗死心肌作用机制的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年3期
页码:
315-318
栏目:
综述
出版日期:
2016-06-20

文章信息/Info

Title:
Research Progress of Cardiac Stem Cells Repairing Infarction Myocardial Function Mechanism
作者:
王艳1综述石蓓12审校
1.遵义医学院研究生院,贵州 遵义 563003; 2.遵义医学院附属医院心内科,贵州 遵义 563003
Author(s):
WANG Yan1SHI Bei12
1.The Graduate School of Zunyi Medical College, Zunyi 563003, Guizhou, China; 2. The Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China
关键词:
心脏干细胞 外泌体 心肌梗死 再生治疗
Keywords:
Cardiac stem cells Exosome Myocardial infarction Regeneration treatments
分类号:
R543.3
DOI:
10.16806/j.cnki.issn.1004-3934.2016.03.027
文献标志码:
A
摘要:
心脏干细胞被发现于哺乳动物心脏组织中已有十余年,在此期间的众多研究均证实了心脏干细胞可再生修复梗死心肌,改善心脏功能。研究者们认为心脏干细胞发挥修复梗死心肌的作用机制可能与其固有特性相关,包括直接分化为功能心肌细胞,通过旁分泌各种细胞因子改善心肌梗死区域微环境,促进血管新生。现对心脏干细胞作用机制的研究现状及所面临的问题进行综述,以期为转化医学发展与心脏疾病的防治开拓新的方向与策略。
Abstract:
Cardiac stem cells(CSCs)were found in the tissue of the mammalian heart has more than 10 years. During this time many of the studies have confirmed that CSCs can regenerate and repair infarcted myocardium and improve heart function. The researchers argue that CSCs play to the role of the repair infarcted myocardium mechanism may be related to its inherent characteristics including direct differentiation into functional myocardial cells. Through paracrine microenvironment of various cytokines, myocardial infarction area will be improved and angiogenesis promoted. In this paper, the current research mechanisms of CSCs that repair infarcted and the problems facing were reviewed in order to find a new direction and strategy for the development of transforming medicine and heart disease prevention.

参考文献/References:

[1] Laflamme MA, Murry CE. Heart regeneration[J].Nature,2011,473(11):326-335.
[2] Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration[J].Cell,2003,114(6):763-776.
[3] Zeng B, Tong S, Ren X,et al. Cardiac cell proliferation assessed by EdU, a novel analysis of cardiac regeneration[J]. Cytotechnology, 2014,107(3):115-121.
[4] Chugh AR, Beache GM, Loughran JH, et al. Administration of cardiac stem cells in patients with ischemic cardiomyopathy:the SCIPIO trial:surgical aspects and interim analysis of myocardial function and viability by magnetic resonance[J].Circulation,2012,126(11):54-64.
[5] Quaini F, Urbanek K, Beltrami AP, et al. Chimerism of the transplanted heart[J]. N Engl J Med,2002,346(1):5-15.
[6] Barile L, Cerisoli F, Frati G, et al. Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart[J]. J Cell Mol Med,2011,15(1):63-71.
[7] Sun Q, Zhang Z, Sun Z,et al.The potential and challenges of using stem cells for cardiovascular repair and regeneration[J].Genes Dis,2014,223(12):113-119.
[8] Smith AJ, Lewis FC, Aquila I,et al. Isolation and characterization of resident endogenous c-Kit cardiac stem cells from the adult mouse and rat heart[J]. Nat Protoc,2014,321(21):1662-1681.
[9] Gan J, Sonntag HJ, Tang MK,et al.Integrative analysis of the developing postnatal mouse heart transcriptome[J].PLoS One,2015,10(7):119-206.
[10] Hosoda T. C-kit-positive cardiac stem cells and myocardial regeneration[J].Am J Cardiovasc Dis,2012,2(1):58-67.
[11] Makkar RR, Smith RR, Cheng K, et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction(CADUCEUS): a prospective, randomised phase 1 trial[J]. Lancet,2012,379(9819):895-904.
[12] Bolli R, Chugh AR, D'Amario D, et al. Cardiac stem cells in patients with ischemic cardiomyopathy(SCIPIO):initial results of a randomized phase 1 trial [J].Lancet,2011,378(9806):1847-1857.
[13] Makkar RR, Smith RR, Cheng K, et al. Intracoronary cardiospehere-derived cells for heart regeneration after myocardial infarction(CADUCEUS):a prospective, randomized phase 1trial[J].Lancet,2012,379(9819):895-904.
[14] Keith MC, Bolli R.“String Theory” of c-kit(pos)cardiac cells:a new paradigm regarding the nature of these cells that may reconcile apparently discrepant results[J].Circ Res,2015,116(11):1216-1230.
[15] Carr CA, Stuckey DJ, Tan JJ, et al. Cardiospere-derived cells improve function in the infarcted rat heart for at least 16 weeks—an MRI study[J].PLoS One,2011,6(10):e25669.
[16] Fioret BA, Heimfeld JD, Paik DT,et al. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis[J]. Cell Rep,2014,52(8):229-241.
[17] Ellison G, Vicinanza C, Smith AJ, et al. Adult c-kit(pos)cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair[J].Cell,2013,154(12):827-842.
[18] van Berlo JH, Kanisicak O, Maillet M, et al. c-kit+ cells minimally contribute cardiomyocytes to the heart[J].Nature,2014,509(3):337-341.
[19] Chimenti I, Smith RR, Li TS, et al. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice[J]. Circ Res,2010,106(5):971-980.
[20] Tang XL, Rokosh G, Sanganalmath SK, et al. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction[J].Circulation,2010,121(2):293-305.
[21] Chen L, Wang Y, Pan Y, et al. Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury[J]. Biochem Biophys Res Commum,2013,431(3):566-571.
[22] Wang K, Zhao X, Kuang C, et al. Overexpression of SDF-1alpha enhanced migration and engraftment of cardiac stem cells and reduced infarcted size via CXCR4/PI3K pathway[J].PLoS One,2012,7(9):e43922.
[23] Zakharoval L, Mastroeni D, Mutlu N, et al. Transplantation of cardiac progenitor cell sheet onto infarcted heart promotes cardiogenesis and improves function[J].Cardiovasc Res,2010,87(1):40-49.
[24] Maxeiner H, Krehbiehl N, Woitasky N, et al.New insights into paracrine mechanisms of human cardiac progenitor cells[J].Eur J Heart Fail,2010,12(7):730-737.
[25] Gray WD, French KM, Ghosh-Choudhary S, et al. Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology[J]. Circ Res,2015,116(2): 255-263.
[26] Lai RC, Arslan F, Lee MM, et al.Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury[J]. Stem Cell Res,2010,4(6):214-222.
[27] Camussi G, Deregibus MC, Cantaluppi V, et al.Role of stem cell derived mecrovesicles in the paracrine action of stem cells[J].Biochem Soc Trans,2013,41(1):283-287.
[28] Malik ZA, Kott KS, Poe AJ, et al.Cardiac myocyte exosomes:stability, HSP60, and proteomics[J].Am J Physiol Heart Circ Physiol,2013,304(7):954-965.
[29] Zhang Z,Yang J,Yan W,et al.Pretreatment of cardiac stem cells with exosomes derived from mesenhymal stem cells enhances myocardial repair[J].Am Heart Assoc,2016,5(1):e002856.
[30] Williams AR, Hatzistergos KE, Addicott B, et al. Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction[J]. Circulation,2013,127(2):213-223.

备注/Memo

备注/Memo:
作者简介:王艳(1988—),硕士,主要从事冠状动脉介入与再狭窄研究。Email:1321246876@qq.com 通信作者:石蓓(1964—),教授,硕士,主要从事冠状动脉介入与再狭窄研究。Email:shibei2147@163.com
更新日期/Last Update: 2016-05-25