[1]郭得杰 来利红.新型生物标志物对心力衰竭预后价值的研究进展[J].心血管病学进展,2025,(10):892.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.007]
 GUO Dejie,LAI Lihong.Prognostic Value of Novel Biomarkers in Heart Failure[J].Advances in Cardiovascular Diseases,2025,(10):892.[doi:10.16806/j.cnki.issn.1004-3934.2025.10.007]
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新型生物标志物对心力衰竭预后价值的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年10期
页码:
892
栏目:
综述
出版日期:
2025-10-25

文章信息/Info

Title:
Prognostic Value of Novel Biomarkers in Heart Failure
作者:
郭得杰 来利红
(河南科技大学临床医学院 河南科技大学第一附属医院心血管内科,河南 洛阳 471003)
Author(s):
GUO DejieLAI Lihong
(Department of Cardiovascular Medicine,First Affiliated Hospital of Henan University of Science and TechnologySchool of Clinical Medicine,Henan University of Science and Technology,Luoyang 471000HenanChina)
关键词:
心力衰竭生物标志物可溶性生长刺激表达基因2蛋白半乳凝集素-3预后价值
Keywords:
Heart failureBiomarkerSoluble suppression of tumorigenicity 2Galectin-3Prognostic value
DOI:
10.16806/j.cnki.issn.1004-3934.2025.10.007
摘要:
心力衰竭(HF)是多种心血管疾病进展的终末阶段,预后评估一直是临床研究的重要方向。传统生物标志物虽广泛用于HF的诊断和预后评估,但因易受其他因素干扰,导致其预后评估的精准性受限。近年来,越来越多的研究致力于探索新型生物标志物在HF预后中的应用价值,但由于标志物的特异性不足、检测标准化缺失,以及多靶点联合应用的复杂性等诸多原因,致使其临床转化仍面临挑战。本文旨在总结新型生物标志物在临床应用中的现状和最新进展,并探讨其相关性,以期改善HF患者的预后。
Abstract:
Heart failure(HF)represents the end-stage progression of various cardiovascular diseases,and prognostic assessment has always been a critical focus of clinical research. Although traditional biomarkers are widely used for the diagnosis and prognostic evaluation of HF,their accuracy in prognostic evaluation is limited due to susceptibility to interference from other factors. In recent years,an increasing number of studies have been dedicated to exploring the prognostic value of novel markers in HF. However,clinical translation still faces challenges due to insufficient specificity of these markers,lack of standardized detection methods,and the complexity of multi-target combined applications,among other reasons. This article aims to summarize the current status and latest advancements in the clinical application of novel biomarkers ,to optimize risk stratification and ultimately improve prognosis

参考文献/References:

[1] 刘明波,何新叶,杨晓红,等. 《中国心血管健康与疾病报告2023》要点解读[J]. 中国全科医学,2025,28(1):20-38.

[2] Khan MS,Shahid I,Bennis A,et al. Global epidemiology of heart failure[J]. Nat Rev Cardiol,2024,21(10):717-734.

[3] Pieroni M,Zocchi C,Ciabatti M. Cardiac involvement in Fabry disease:Recent advances,unresolved issues,and unmet needs[J]. Eur Heart J Suppl,2025,27(suppl 1):i51-i55.

[4] 中国医师协会心力衰竭专业委员会,国家心血管病专家委员会心力衰竭专业委员会,中华心力衰竭和心肌病杂志编辑委员会. 心力衰竭生物标志物临床应用中国专家共识[J]. 中华心力衰竭和心肌病杂志,2022,6(3):175-192.

[5] Singh G,Bamba H,Inban P,et al. The role of biomarkers in the prognosis and risk stratification in heart failure:a systematic review[J]. Dis Mon,2024,70(10):101782.

[6] 罗年桑,张海峰,刘品明,等. 血清可溶性ST2联合白细胞介素-33对射血分数保留的心力衰竭辅助诊断价值的初探[J]. 中华心血管病杂志,2017,45(3):198-203.

[7] Pusceddu I,Dieplinger B,Mueller T. ST2 and the ST2/IL-33 signalling pathway-biochemistry and pathophysiology in animal models and humans[J]. Clin Chim Acta,2019,495:493-500.

[8] Homsak E,Gruson D. Soluble ST2:a complex and diverse role in several diseases[J]. Clin Chim Acta,2020,507:75-87.

[9] Lotierzo M,Dupuy AM,Kalmanovich E,et al. sST2 as a value-added biomarker in heart failure[J]. Clin Chim Acta,2020,501:120-130.

[10] Zhang T,Xu C,Zhao R,et al. Diagnostic value of sST2 in cardiovascular diseases:a systematic review and meta-analysis[J]. Front Cardiovasc Med,2021,8:697837.

[11] Wei P,Liu L,Wang X,et al. Expression of soluble ST2 in patients with essential hypertension and its relationship with left ventricular hypertrophy[J]. ESC Heart Fail,2023,10(1):303-310.

[12] Natorska J,Z?bczyk M,Undas A. Neutrophil extracellular traps (NETs) in cardiovascular diseases:from molecular mechanisms to therapeutic interventions[J]. Kardiol Pol,2023,81(12):1205-1216.

[13] Li B,Dowley M,Langley S,et al. The mortality implications of increasing and decreasing sST2 levels during acute decompensated heart failure[J]. Eur Heart J,2024,45(suppl 1):ehae666.976.

[14] Cao ZQ,Yu X,Leng P. Research progress on the role of gal-3 in cardio/cerebrovascular diseases[J]. Biomed Pharmacother,2021,133:111066.

[15] Echouffo-Tcheugui JB,Zhang S,Florido R,et al. Galectin-3,metabolic risk,and incident heart failure:the ARIC study[J]. J Am Heart Assoc,2024,13(6):e031607.

[16] Vlachou F,Varela A,Stathopoulou K,et al. Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model[J]. Cell Mol Life Sci,2022,79(5):250.

[17] Berezin AE,Berezin AA. Biomarkers in heart failure:from research to clinical practice[J]. Ann Lab Med,2023,43(3):225-236.

[18] Hara A,Niwa M,Kanayama T,et al. Galectin-3:a potential prognostic and diagnostic marker for heart disease and detection of early stage pathology[J]. Biomolecules,2020,10(9):1277.

[19] Trippel TD,Mende M,Düngen HD,et al. The diagnostic and prognostic value of galectin-3 in patients at risk for heart failure with preserved ejection fraction:results from the DIAST-CHF study[J]. ESC Heart Fail,2021,8(2):829-841.

[20] Zaborska B,Sikora-Fr?c M,Smar? K,et al. The role of galectin-3 in heart failure-the diagnostic,prognostic and therapeutic potential-where do we stand?[J]. Int J Mol Sci,2023,24(17):13111.

[21] Lau ES,Liu E,Paniagua SM,et al. Galectin-3 inhibition with modified citrus pectin in hypertension[J]. JACC Basic Transl Sci,2021,6(1):12-21.

[22] Schwarz A,Kinscherf R,Bonaterra GA. Role of the stress- and inflammation-induced cytokine GDF-15 in cardiovascular diseases:from basic research to clinical relevance[J]. Rev Cardiovasc Med,2023,24(3):81.

[23] Myrmel GMS,Steiro OT,Tjora HL,et al. Growth differentiation factor 15:a prognostic marker in patients with acute chest pain without acute myocardial infarction[J]. Clin Chem,2023,69(6):649-660.

[24] Silva-Bermudez LS,Klüter H,Kzhyshkowska JG. Macrophages as a source and target of GDF-15[J]. Int J Mol Sci,2024,25(13):7313.

[25] Rochette L,Dogon G,Zeller M,et al. GDF15 and cardiac cells:current concepts and new insights[J]. Int J Mol Sci,2021,22(16):8889.

[26] Kosum P,Siranart N,Mattanapojanat N,et al. GDF-15:a novel biomarker of heart failure predicts short-term and long-term heart-failure rehospitalization and short-term mortality in patients with acute heart failure syndrome[J]. BMC Cardiovasc Disord,2024,24(1):151.

[27] Ueland T,Gullestad L,Kou L,et al. Growth differentiation factor 15 predicts poor prognosis in patients with heart failure and reduced ejection fraction and anemia:results from RED-HF[J]. Clin Res Cardiol,2022,111(4):440-450.

[28] Lyu L,Xu J,Xv C,et al. Prognostic value of growth differentiation factor-15 in heart failure among whole ejection fraction phenotypes[J]. ESC Heart Fail,2024,11(4):2295-2304.

[29] Farag NM,Mousa M,Elsayed E,et al. GDF-15 and hepcidin as a therapeutic target for anemia in chronic kidney disease[J]. Ital J Pediatr,2023,49(1):106.

[30] Marsche G,Stadler JT,Kargl J,et al. Understanding myeloperoxidase-induced damage to HDL structure and function in the vessel wall:implications for HDL-based therapies[J]. Antioxidants (Basel),2022,11(3):556.

[31] Reichlin T,Socrates T,Egli P,et al. Use of myeloperoxidase for risk stratification in acute heart failure[J]. Clin Chem,2010,56(6):944-951.

[32] Geissen S,Braumann S,Adler J,et al. Treatment of left ventricular dysfunction in dilated cardiomyopathy with a myeloperoxidase inhibitor[J]. medRxiv,2022.DOI:https://doi.org/10.1101/2022.11.02.22281785

[33] Chaikijurajai T,Tang WHW. Reappraisal of inflammatory biomarkers in heart failure[J]. Curr Heart Fail Rep,2020,17(1):9-19.

[34] Erdo?an SB,Sel?uk ?N,Ba?top?u M,et al. Critical limb ischemia patients clinically improving with medical treatment have lower neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios[J]. Vascular,2021,29(6):920-926.

[35] Delcea C,Adrian Buzea C,Dobrev D,et al. Prognostic roles of neutrophil-lymphocyte,monocyte-lymphocyte and platelet-lymphocyte ratios for long-term all-cause mortality in heart failure[J]. Int J Cardiol Heart Vasc,2024,54:101502.

[36] Zhang Q,Si D,Zhang Z,et al. Value of the platelet-to-lymphocyte ratio in the prediction of left ventricular thrombus in anterior ST-elevation myocardial infarction with left ventricular dysfunction[J]. BMC Cardiovasc Disord,2020,20(1):428.

[37] Chen W,Xin S,Xu B. Value research of NLR,PLR,and RDW in prognostic assessment of patients with colorectal cancer[J]. J Healthc Eng,2022,2022:7971415.

[38] Zahorec R. Neutrophil-to-lymphocyte ratio,past,present and future perspectives[J]. Bratisl Lek Listy,2021,122(7):474-488.

[39] Chilton PM,Embry CA,Mitchell TC. Effects of differences in lipid A structure on TLR4 pro-inflammatory signaling and inflammasome activation[J]. Front Immunol,2012,3:154.

[40] Wang R,Wu J,Ye H,et al. Application value of systemic inflammatory indexes in the clinical evaluation of patients with heart failure with preserved ejection fraction (HFpEF)[J]. Medicina (Kaunas),2022,58(10):1473.

[41] 魏亚君,侯泽,刘雨庭,等. 单核细胞与高密度脂蛋白胆固醇比值评估射血分数降低型心力衰竭患者的预后价值[J]. 中华预防医学杂志,2025,59(3):309-316.

[42] Amezcua-Castillo E,González-Pacheco H,Sáenz-San Martín A,et al. C-reactive protein:the quintessential marker of systemic inflammation in coronary artery disease-Advancing toward precision medicine[J]. Biomedicines,2023,11(9):2444.

[43] Erd?l MA,Yayla KG. Relationship between C-reactive protein to albumin ratio and coronary artery calcium score and CAD-RADS scores with coronary computed tomography angiography[J]. Turk J Med Sci,2021,51(5):2674-2682.

[44] Karaba? Y,?a?da? M,Rencuzogullari I,et al. Usefulness of the C-reactive protein/albumin ratio for predicting no-reflow in ST-elevation myocardial infarction treated with primary percutaneous coronary intervention[J]. Eur J Clin Invest,2018,48(6):e12928.

[45] Ye M,Yu G,Han F,et al. Non-linear association of CAR with all-cause and cardiovascular mortality in coronary heart disease:a retrospective cohort study from NHANES[J]. Clin Appl Thromb Hemost,2024,30:10760296241271382.

[46] Li J,Man Q,Wang Y,et al. The metabolic vulnerability index as a novel tool for mortality risk stratification in a large-scale population-based cohort[J]. Redox Biol,2025,81:103585.

[47] Kumar S,Conners KM,Shearer JJ,et al. Frailty and metabolic vulnerability in heart failure:a community cohort study[J]. J Am Heart Assoc,2024,13(8):e031616.

[48] Kuku KO,Shearer JJ,Joo J,et al. Cross-sectional evaluation of the metabolic vulnerability index in heart failure populations[J]. BMC Cardiovasc Disord,2025,25(1):292.

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