[1]陈妍羽 刘洁 陈燕 彭华.可溶性肾素/肾素前体受体在心血管疾病和肾脏疾病中的研究进展[J].心血管病学进展,2024,(8):737.[doi:10.16806/j.cnki.issn.1004-3934.2024.08.014]
 CHEN Yanyu,LIU Jie,CHEN Yan,et al.Soluble (Pro)renin Receptor in Cardiovascular Disease and Kidney Disease[J].Advances in Cardiovascular Diseases,2024,(8):737.[doi:10.16806/j.cnki.issn.1004-3934.2024.08.014]
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可溶性肾素/肾素前体受体在心血管疾病和肾脏疾病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年8期
页码:
737
栏目:
综述
出版日期:
2024-08-25

文章信息/Info

Title:
Soluble (Pro)renin Receptor in Cardiovascular Disease and Kidney Disease
作者:
陈妍羽 刘洁 陈燕 彭华
(华中科技大学同济医学院附属协和医院儿科,湖北 武汉 430022)
Author(s):
CHEN YanyuLIU JieCHEN YanPENG Hua
(Department of pediatrics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,Hubei,China)
关键词:
可溶性肾素/肾素前体受体高血压心力衰竭水孔蛋白2
Keywords:
Soluble (Pro)renin receptorHypertensionHeart failure Aquaporin 2
DOI:
10.16806/j.cnki.issn.1004-3934.2024.08.014
摘要:
肾素/肾素前体受体[(P)RR]是肾素-血管紧张素系统的重要组成部分,参与人体的多种病理生理过程,并且其可溶形式是由位点-1蛋白酶切割形成的相对分子质量28 000 的蛋白质,即s(P)RR。近年来越来越多的研究证明s(P)RR与心血管疾病和肾脏疾病的发生和进展有密切联系,这就为其成为这些疾病新型的生物标志物或治疗靶点提供了可能性。由于尿崩症、心力衰竭等疾病缺乏针对性特效药且现有治疗效果不佳,因此进一步了解s(P)RR参与这些疾病的具体机制有利于提供全新的诊治方向。现旨在对s(P)RR的结构、功能以及在心血管疾病和肾脏疾病中的研究进展进行综述。
Abstract:
(P ro)renin receptor [(P)RR]is an important part of renin-angiotensin system,involved in a variety of human pathophysiological processes,and its soluble form is a protein with a relative molecular weight of 28 000 cleaved by site-1 protease,namely s(P)RR. In recent years,more and more studies have proved that s(P)RR is closely related to the occurrence and progression of cardiovascular disease and kidney disease ,which provides the possibility for it to become a novel biomarker or therapeutic target for these diseases. Due to the lack of specific drugs for diabetes insipidus,heart failure and other diseases,and the poor effect of existing treatments ,further understanding of the specific mechanism of s(P)RR involvement in these diseases is conducive to providing a new direction for diagnosis and treatment. This article aims to review the structure,function and research progress of s(P)RR in cardiovascular disease and kidney disease.

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更新日期/Last Update: 2024-09-13