[1]付亚萌 张光明.内质网应激与内皮功能障碍关系及临床治疗研究进展[J].心血管病学进展,2024,(3):243.[doi:10.16806/j.cnki.issn.1004-3934.2024.03.012]
　FU YamengZHANG Guangming.Research progress on the relationship between endoplasmic reticulum stress and endothelial dysfunction and its clinical treatment[J].Advances in Cardiovascular Diseases,2024,(3):243.[doi:10.16806/j.cnki.issn.1004-3934.2024.03.012]
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内质网应激与内皮功能障碍关系及临床治疗研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年3期
页码:
243
栏目:
综述
出版日期:
2024-03-25

文章信息/Info

Title:
Research progress on the relationship between endoplasmic reticulum stress and endothelial dysfunction and its clinical treatment
作者:
付亚萌 张光明
(河北医科大学第二医院心内一科,河北 石家庄 050000)
Author(s):
FU YamengZHANG Guangming
(Second Hospital of Hebei Medical UniversityShijiazhuang 050000HebaiChina)
关键词:
内质网应激; 未折叠蛋白质反应; 内皮功能障碍; 动脉粥样硬化
Keywords:
Endoplasmic reticulum stress; Unfolded protein response; Endothelial dysfunction; Atherosclerosis
DOI:
10.16806/j.cnki.issn.1004-3934.2024.03.012
摘要:
内皮功能障碍作为动脉粥样硬化的早期关键事件，不仅贯穿动脉粥样硬化病变全程，还与其他多种心血管疾病的发病密切相关。近年来有研究发现，内质网应激（ERS）相关蛋白在心血管疾病中的表达呈上升趋势，ERS可能通过促进内皮功能障碍加重心血管疾病的进展。现总结ERS与内皮功能障碍及动脉粥样硬化的发病机制关系，并介绍一些缓解ERS的药物，有望为临床实现内皮功能障碍及心血管疾病的治疗提供一定参考价值。
Abstract:
As an early critical event in atherosclerosis (AS), endothelial dysfunction runs throughout the AS process and is closely related to the pathogenesis of many other cardiovascular diseases. It has been found that the expression of endoplasmic reticulum stress (ERS) -related proteins is increasing in cardiovascular disease, ERS may exacerbate the progression of cardiovascular disease by promoting endothelial dysfunction. ERS may aggravate the progression of cardiovascular disease by promoting endothelial dysfunction. This article summarizes the research progress of the relationship between ERS and endothelial dysfunction and AS, and introduces some drugs to alleviate ERS, which is expected to provide certain reference value for the clinical treatment of endothelial dysfunction and cardiovascular diseases.

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更新日期/Last Update: 2024-04-26