[1]郭良敏?罗强?刘梅 ?刘亚萍 ?卢燕 ?汪汉.高血压与前列腺癌因果关系的孟德尔随机化研究[J].心血管病学进展,2023,(7):669.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.021]
　GUO Liangmin,LUO Qiang,LIU Mei,et al.Mendel Randomization Study on the Causality of Hypertension and Prostate Cancer[J].Advances in Cardiovascular Diseases,2023,(7):669.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.021]
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高血压与前列腺癌因果关系的孟德尔随机化研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年7期
页码:
669
栏目:
论著
出版日期:
2023-07-25

文章信息/Info

Title:
Mendel Randomization Study on the Causality of Hypertension and Prostate Cancer
作者:
郭良敏1?罗强1?刘梅 1?刘亚萍 2?卢燕 2?汪汉 1; 2
(1西南交通大学附属医院 成都市第三人民医院心内科,四川 成都 610031;2 川北医学院老年科,四川 南充637000)
Author(s):
GUO Liangmin1; LUO Qiang1; LIU Mei1; LIU Yaping2; LU Yan2; WANG Han12
(1.Department of Cardiology,Affiliated Hospital of Southwest Jiaotong University,The Third People’s Hospital of Chengdu,Chengdu 610031,Sichuan,China;2.Department of geriatrics,North Sichuan Medical College,Nanchong 637000,Sichuan,China)
关键词:
高血压; 前列腺癌; 孟德尔随机化; 单核苷酸多态性
Keywords:
Hypertension; Prostate cancer; Mendel randomization; Single nucleotide polymorphism
DOI:
10.16806/j.cnki.issn.1004-3934.2023.07.021
摘要:
目的 众多研究阐述了高血压与前列腺癌风险的关系，但由于观察性研究中二者的因果关系并不明确。本研究通过双向两样本孟德尔随机化 (MR) 探讨高血压与前列腺癌的因果关系。方法 我们利用全基因组关联研究汇总数据，其中高血压来自于UKB数据库，前列腺癌数据来自于一项大型的全基因组关联研究。利用逆方差加权法，加权中位数法，MR-Egger等方法进行MR分析，然后进行敏感性分析包括水平多效性分析，Cochran Q检验及留一法评估结果可靠性。结果68个与高血压密切相关的单核苷酸多态性位点被筛选出来作为工具变量。基于逆方差加权法，我们发现高血压与前列腺癌之间存在密切的因果关系（OR=0.53, 95% CI 0.286 ～0.966，P=0.038），这提示高血压与前列腺癌之间为负向因果关系。逆向MR分析显示前列腺癌不是高血压发病风险的危险因素(P=0.208)。MR-Egger截距和Cochran Q检验表明，本研究中不存在水平多效性和异质性的易感性（P >0.05）。 结论 孟德尔随机化分析提示高血压与前列腺癌风险反向相关，而前列腺癌并不升高高血压风险。
Abstract:
Objective Numbers studies have elucidated the relationship between hypertension and prostate cancer risk,but the causal relationship between the two is unclear in observational studies. This study explored the causal relationship between hypertension and prostate cancer through two-sample bidirectional Mendelian randomization (MR). Method We summarize the data set using the genome-wide association study. Hypertension comes from the UKB database,and prostate cancer data comes from a large genome-wide association study. The inverse variance weighted method, weighted median method,and MR-Egger were used to conduct MR analysis,and then sensitivity analysis was conducted, including horizontal multiple validity analysis,Cochran Q test,and leave-one-out method to evaluate the reliability of these results. Results 68 single nucleotide polymorphisms loci closely related to hypertension were screened as instrumental variables. Based on the inverse variance weighted method, we found a close causal relationship between hypertension and prostate cancer risk ( OR=0.53,95% CI 0.286 ～0.966, P=0.038),indicating a negative causal relationship between hypertension and prostate cancer. Reverse MR analysis showed that prostate cancer was not a risk factor for hypertension (P=0.208). MR Egger intercept and Cochran Q test showed that there was no susceptibility to horizontal pleiotropy and heterogeneity in this study (All P values>0.05). Conclusion Mendelian randomization analysis suggested that hypertension was inversely associated with the risk of prostate cancer.

参考文献/References:

[1] Zhang M,Shi Y,Zhou B,et al. Prevalence,awareness,treatment,and control of hypertension in China,2004-18:findings from six rounds of a national survey[J]. BMJ,2023,380:e071952.

[2] Lu J,Lu Y,Wang X,et al. Prevalence,awareness,treatment,and control of hypertension in China:data from 1·7 million adults in a population-based screening study (China PEACE Million Persons Project)[J]. Lancet,2017,390(10112):2549-2558.

[3] Sahni G. Onco-Hypertension:changing paradigm of treating hypertension in patients with cancer[J]. J Clin Oncol,2023,41(5):958-963.

[4] Connaughton M,Dabagh M. Association of hypertension and organ-specific cancer:a meta-analysis[J]. Healthcare (Basel),2022,10(6):1074.

[5] Navin S,Ioffe V. The association between hypertension and prostate cancer[J]. Rev Urol,2017,19(2):113-118.

[6] Liang Z,Xie B,Li J,et al. Hypertension and risk of prostate cancer:a systematic review and meta-analysis[J]. Sci Rep,2016,6:31358.

[7] Stocks T,Hergens MP,Englund A,et al. Blood pressure,body size and prostate cancer risk in the Swedish Construction Workers cohort[J]. Int J Cancer,2010,127(7):1660-1668.

[8] Luo Q,Chen J,Qin L,et al. Psoriasis may increase the risk of lung cancer:a two-sample Mendelian randomization study[J]. J Eur Acad Dermatol Venereol ,2022,36(11):2113-2119.

[9] Luo Q,Yan W,Nie Q,et al. Vitamin D and heart failure:a two-sample mendelian randomization study[J]. Nutr Metab Cardiovas Dis ,2022,32(11):2612-2620.

[10] Schumacher FR,Al Olama AA,Berndt SI,et al. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci[J]. Nat Genet,2018,50(7):928-936.

[11] Stocks T,Van Hemelrijck M,Manjer J,et al. Blood pressure and risk of cancer incidence and mortality in the Metabolic Syndrome and Cancer Project[J]. Hypertension,2012,59(4):802-810.

[12] Fitzpatrick AL,Daling JR,Furberg CD,et al. Hypertension,heart rate,use of antihypertensives, and incident prostate cancer[J]. Ann Epidemiol,2001,11(8):534-542.

[13] Alexander MR,Hank S,Dale BL,et al. A single nucleotide polymorphism in SH2B3/LNK promotes hypertension development and renal damage[J]. Circ Res,2022,131(9):731-747.

[14] Hung RJ,Ulrich CM,Goode EL. Cross cancer genomic investigation of inflammation pathway for five common cancers:lung,ovary,prostate,breast,and colorectal cancer[J]. J Natl Cancer Inst,2015,107(11):djv246.

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更新日期/Last Update: 2023-08-18