[1]马婕 王文娟 余静.抗血管生成靶向药物致高血压的机制进展[J].心血管病学进展,2023,(9):841.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.017]
 MA Jie,WANG Wenjuan,YU Jing.Mechanism of Hypertension Induced by Antiangiogenic Targeted Drugs[J].Advances in Cardiovascular Diseases,2023,(9):841.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.017]
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抗血管生成靶向药物致高血压的机制进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年9期
页码:
841
栏目:
综述
出版日期:
2023-09-25

文章信息/Info

Title:
Mechanism of Hypertension Induced by Antiangiogenic Targeted Drugs
作者:
马婕 王文娟 余静
(兰州大学第二医院高血压中心,甘肃 兰州 730000)
Author(s):
MA Jie WANG Wenjuan YU Jing
(Center of Hypertension, Lanzhou University Second Hospital, Lanzhou 730000GansuChina)
关键词:
抗血管生成靶向药物高血压PI3K/Akt盐敏感性高血压
Keywords:
Anti-angiogenesis targeting drugHypertensionPI3K/AktSalt sensitive hypertension
DOI:
10.16806/j.cnki.issn.1004-3934.2023.09.017
摘要:
近年来以抗血管生成通路为靶点而研发的新型抗肿瘤药物,在显著提高癌症患者存活率的同时,亦伴随出现了心脏毒性等副作用,而高血压是其最常见的副作用之一,也是许多心血管疾病的危险因素。现总结目前抗血管生成靶向药物致相关性高血压可能的作用机制,包括一氧化氮信号通路、内皮素-1系统激活、氧化应激、血管舒缩功能异常、PI3K/Akt信号通路的激活和盐敏感性高血压以及肾素-血管紧张素系统等。
Abstract:
Recently, new anti-tumor drugs, which are targeted at angiogenesis pathways, can significantly improve cancer survival, but also cause cardiotoxicity in some patients. Hypertension is the most common side effects, and it is a risk factor for many cardiovascular diseases as well. The article summarized the possible mechanisms of this kind of hypertension, including nitric oxide signaling pathway and endothelin-1 system, oxidative stress, abnormal vasomotor function, activation of PI3K/Akt pathway, salt-sensitive hypertension, and renin-angiotensin system, etc

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更新日期/Last Update: 2023-10-17