[1]殷人麟 尤华 郑林.前蛋白转化酶枯草溶菌素9抑制剂与冠状动脉粥样硬化斑块逆转的研究进展[J].心血管病学进展,2022,(8):710-714.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.011]
 YIN Renlin,YOU hua,Zheng Lin?/html>.PCSK9 Inhibitors in?nhibiting Coronary Atherosclerotic Plaque[J].Advances in Cardiovascular Diseases,2022,(8):710-714.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.011]
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前蛋白转化酶枯草溶菌素9抑制剂与冠状动脉粥样硬化斑块逆转的研究进展(/HTML)
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年8期
页码:
710-714
栏目:
综述
出版日期:
2022-08-25

文章信息/Info

Title:
PCSK9 Inhibitors in?nhibiting Coronary Atherosclerotic Plaque
作者:
殷人麟 尤华 郑林
?苏州大学附属苏州九院心血管内科,江苏 苏州 215000)
Author(s):
YIN RenlinYOU huaZheng Lin?/html>
(Cardiology Department,Suzhou Ninth People’s Hospital,Soochow University,Suzhou 215000,Jiangsu,China)
关键词:
前蛋白转化酶枯草溶菌素9抑制剂降脂抗炎冠状动脉粥样硬化斑块
Keywords:
Proprotein convertase subtilisin/kexin type 9 inhibitorLipid loweringAnti-inflammatoryCoronary atherosclerotic plaque
DOI:
10.16806/j.cnki.issn.1004-3934.2022.08.011
摘要:
近年来,前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂的出现给冠心病患者带来了新的治疗手段。对于PCSK9抑制剂能否逆转冠状动脉粥样硬化斑块,相关研究较少,但却是笔者关注的焦点,现从冠状动脉粥样硬化斑块逆转的机制,PCSK9抑制剂降脂、抗炎以及PCSK9抑制剂逆转冠状动脉粥样硬化斑块在临床试验中的应用进行综述。
Abstract:
In recent years,the emergence of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors has brought new treatments to patients with coronary heart disease. However,there were few studies on whether PCSK9 inhibitors can reverse coronary atherosclerotic plaque,but it is the focus of our attention. This paper reviews the mechanism of reversing coronary atherosclerotic plaque,the lipid-lowering and anti-inflammatory effects of PCSK9 inhibitors,and the reversal effect of PCSK9 inhibitors on coronary atherosclerotic plaque in clinical trials.

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备注/Memo

备注/Memo:
基金项目:苏州市科技发展计划项目(SYSD2019202)
通信作者:郑林,E-mail:358677161@qq.com ?/span>
更新日期/Last Update: 2022-10-08