[1]贾晓艳 安晋阳 彭可玲 刘永铭.可溶性鸟苷酸环化酶激动剂治疗射血分数保留性心力衰竭的研究进展[J].心血管病学进展,2022,(2):141.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.012]
 JIA Xiaoyan,AN Jinyang,PENG Keling,et al.Soluble Guanylate Cyclase Stimulators in the Treatment of Heart Failure with Preserved Ejection Fraction[J].Advances in Cardiovascular Diseases,2022,(2):141.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.012]
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可溶性鸟苷酸环化酶激动剂治疗射血分数保留性心力衰竭的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年2期
页码:
141
栏目:
综述
出版日期:
2022-02-25

文章信息/Info

Title:
Soluble Guanylate Cyclase Stimulators in the Treatment of Heart Failure with Preserved Ejection Fraction
作者:
贾晓艳1 安晋阳2 彭可玲1 刘永铭1
(1.兰州大学第一医院老年心血管科 甘肃省老年疾病临床医学研究中心,甘肃 兰州 730000 ;2.兰州大学第一医院内分泌科,甘肃 兰州 730000 )
Author(s):
JIA Xiaoyan1 AN Jinyang2 PENG Keling1 LIU Yongming1
(1.Department of Geriatric Cardiology,The First Hospital of Lanzhou University,Gansu Provincial Clinical Research Center for Geriatric Medicine,Lanzhou 730000,Gansu,China; 2.Department of Endocrinology,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China) (202061)(20YF8FA079) E-mailcardtonm@263.net
关键词:
心力衰竭射血分数保留性心力衰竭射血分数降低性心力衰竭可溶性鸟苷酸环化酶激动剂
Keywords:
Heart failure Heart failure with preserved ejection fraction Heart failure with reduced ejection fraction Soluble guanylate cyclase stimulators
DOI:
10.16806/j.cnki.issn.1004-3934.2022.02.012
摘要:
心力衰竭(心衰)发病率、病死率高,是多种心血管疾病的终末阶段,其中射血分数保留性心力衰竭(HFpEF)是一组常见且复杂的临床综合征,约占所有心力衰竭患者的50%。HFpEF预后差,再住院率及死亡率与射血分数降低性心力衰竭(HFrEF)相当。尽管针对HFrEF有了相对完整的指南共识,但目前尚缺乏可真正改善HFpEF患者预后的药物。一氧化氮-可溶性鸟苷酸环化酶(sGC)-环磷酸鸟苷信号通路在心血管疾病中起重要作用,针对这一信号通路的药物可能是治疗心衰的关键;其中一氧化氮敏感性sGC激动剂是作为治疗心衰的新型口服药物,多项试验已证实其可改善HFrEF的预后,但对于sGC激动剂治疗HFpEF的作用机制及研究进展仍缺乏整体认识。现对sGC激动剂相关研究进行综述,并着重分析其在HFpEF患者中的证据支持,以期望对HFpEF的病理机制及sGC激动剂药物治疗方面提供参考。
Abstract:
Heart failure (HF) is the terminal stage of a variety of cardiovascular diseases with high morbidity and fatality rate. HF with preserved ejection fraction (HFpEF) is a common and complex clinical syndrome,accounting for about 50% of all HF patients. Patients with HFpEF have a poor prognosis,with rehospitalization and mortality rates comparable to those of HF with reduced ejection fraction (HFrEF) . Although there is a relatively complete consensus on Guidelines for HFrEF,there is still a lack of drugs that can truly improve the prognosis of patients with HFpEF. Nitric oxide-soluble guanylate cyclase (sGC)- cyclic guanosine monophosphate signaling pathway plays an important role in cardiovascular disease. Targeted drugs targeting this signaling pathway may be the key to the treatment of HF. Nitric oxide sensitive sGC stimulators is a new oral drug for the treatment of HF,and many trials have proved that it can improve the prognosis of HFrEF. However,there is still a lack of comprehensive understanding of the mechanism and research progress of sGC stimulators in the treatment of HFpEF. Therefore,this article reviewed related studies,and focuses on the analysis of the evidence support of sGC stimulators in patients with HFpEF,in order to provide reference for the pathological mechanism of HFpEF and the application of sGC stimulators.

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更新日期/Last Update: 2022-08-19