[1]牛云霞 包针 杨玉春 何鹏义 木胡牙提.冠状动脉慢血流的危险因素及冠状动脉病变特点的研究[J].心血管病学进展,2022,(2):178.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.020]
　IU YunxiaBAO ZhenYANG YuchunHE PengyiMU Huyati.Risk Factors of Coronary Slow Flow and Characteristics of Coronary Artery Lesions[J].Advances in Cardiovascular Diseases,2022,(2):178.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.020]
点击复制

冠状动脉慢血流的危险因素及冠状动脉病变特点的研究()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年2期
页码:
178
栏目:
论著
出版日期:
2022-02-25

文章信息/Info

Title:
Risk Factors of Coronary Slow Flow and Characteristics of Coronary Artery Lesions
作者:
牛云霞 包针 杨玉春 何鹏义 木胡牙提
(新疆医科大学第一附属医院心脏中心综合心脏内科,新疆 乌鲁木齐 830000)
Author(s):
IU YunxiaBAO ZhenYANG YuchunHE PengyiMU Huyati
General Department of Cardiology, Herat Center, the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)
关键词:
冠状动脉慢血流现象; 危险因素; TIMI帧计数
Keywords:
Coronary slow flow phenomenon ; Risk factors; TIMI frame count
DOI:
10.16806/j.cnki.issn.1004-3934.2022.02.020
摘要:
目的 研究冠状动脉慢血流现象（CSFP）患者的危险因素和分析累及冠状动脉病变的特点。方法 回顾性收集本院2019年1月—2021年1月因疑似冠心病行冠状动脉造影术的514例患者，分析患者的临床资料、实验室指标及冠状动脉造影结果等相关资料，按照TIMI血流分级分为慢血流组（n=288）和对照组（n=226），比较两组之间的差异，并通过logistics回归分析探讨CSFP患者的危险因素。结果 （1）两组间在性别、民族、吸烟及饮酒史上存在统计学差异（P＜0.05）。（2）CSFP组的血红蛋白、游离三碘甲状原氨酸、血肌酐值、血尿酸水平、空腹血糖水平和左室舒张末期大小均高于对照组（P＜0.05）；而CSFP组的血小板分布宽度、游离甲状腺素、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A1和白蛋白水平均低于对照组（P＜0.05）；（3）CSFP以三支血管病变最多见，为124例（43.0%），而单支血管病变和双支血管病变病例数一样，均为82例（28.5%）。单支血管病变中最多见的是前降支67例（81.7%），其次是右冠状动脉12例（14.6%），左回旋支较少见；（4）多因素logistic回归分析发现：性别、民族、游离甲状腺素、载脂蛋白A1和白蛋白水平是CSFP患者的独立危险因素。结论 （1）男性、少数民族、游离甲状腺素、载脂蛋白A1和白蛋白水平是CSFP的独立危险因素；（2）CSFP更常见于三支冠状动脉病变组，单支冠状动脉病变者更常见于左前降支。
Abstract:
Objective To study risk factors of the patients with coronary slow flow phenomenon (CSFP) and analyze characteristics of involved coronary artery lesions. Methods Total 514 patients underwent coronary angiography and suspected for coronary heart disease in our hospital from January 2019 to January 202 1 were retrospectively collected. The clinical data ,laboratory indicators and results of coronary angiography were analyzed,and divided into CSFP group ( n=288 ) and control group ( n=226) according to TIMI flow grades to compare their difference s. Risk factors for CSFP were explored through logistics regression analysis . Results (1) There were statistical differences on sex ,ethnicity,smoking and alcohol consumption history between two groups(P＜0.05). (2)Hemoglobin,triiodothyronine,serum creatinine value,serum uric acid level,fasting glucose level and left ventricular end-diastolic size were higher in CSFP group than control group ,while levels of mean platelet distribution width,tetraiodothyronine,total cholesterol,high and low density lipoprotein cholesterol ,apolipoprotein A1 and albumin were lower in CSF P group (P＜0.05). (3)Three-vessel lesion was the most common type in CSF P,accounting for 124 cases(43.0%),while single-vessel and double-vessel lesions possessed the same number of 82 cases(28.5%) . The most common vessel among single-vessel lesions was anterior descending artery with 67 cases(81.7%),followed by right coronary artery with 12 cases(14.6%) and circumflex artery with scarcity . (4)Multivariate logistic regression analysis showed gender,ethnicity,tetraiodothyronine,apolipoprotein A1 and albumin levels were independent risk factors for CSFP. Conclusions (1) Male,ethnic minority,tetraiodothyronine,apolipoprotein A1 and albumin levels are independent risk factors for CSFP. (2)CSFP seems common in three-vessel lesion patients,while the left anterior descending branch would be often involved in single-vessel lesion patients

参考文献/References:

[1].Tambe AA,Demany MA,Zimmerman HA,et al. Angina pectoris and slow flow velocity of dye in coronary arteries—A new angiographic finding[J]. Am Heart J ,1972,84(1):66-71.
[2].Zivanic A,Stankovic I,Ilic I,et al. Prognosis of patients with previous myocardial infarction,coronary slow flow,and normal coronary angiogram[J]. Herz,2020:45(Suppl 1):88-94.
[3].裴宜斌,赵韧.冠状动脉慢血流患者临床资料分析及预后[J].中国老年学杂志,2021,41(3):449-452.
[4].Baysal SS,Koc S.Oxidant-antioxidant balance in patients with coronary slow flow[J]. Pak J Med Sci,2019,35(3):786-792.
[5].Gibson CM,Cannon CP,Daley WL,et al. TIMI frame count:a quantitative method of assessing coronary artery flow[J]. Circulation,1996,93(5):879-888.
[6].剡冬冬,彭瑜,赵晶,等. 冠状动脉慢血流现象临床危险因素及形态学研究[J]. 中国介入心脏病学杂志,2021,29(1),29-34.
[7].Amirzadegan A,Motamed A,Davarpasand T,et al. Clinical characteristics and mid-term outcome of patients with slow coronary flow[J]. Acta Cardiol,2012,67(5):583-587.
[8].Wake R,Yoshiyama M. Gender differences in ischemic heart disease[J]. Recent Pat Cardiovasc Drug Discov,2009,4(3):234-240.
[9].Iorga A,Cunningham CM,Moazeni S,et al. The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy[J]. Biol Sex Differ,2017,8(1):33.
[10].Hackshaw A,Morris JK,Boniface S,et al. Low cigarette consumption and risk of coronary heart disease and stroke:meta-analysis of 141 cohort studies in 55 study reports[J]. BMJ,2018,360:j5855.
[11].Ghaffari S,Tajlil A,Aslanabadi N,et al. Clinical and laboratory predictors of coronary slow flow in coronary angiography[J]. Perfusion,2016,32(1):13-19.
[12].李霞,王枚,马依彤,等. 新疆维吾尔族、哈萨克族、汉族冠心病差异基因筛选及功能路径分析[J]. 中国动脉硬化杂志,2016,24(12):1238-1242.
[13].Rosenson RS,Brewer HBJr,Ansell B,et al.Translation of high-density lipoprotein function into clinical practice:current prospects and future challenges[J]. Circulation,2013,128(11):1256-1267.
[14].Yang N,Su YF,Li WW,et al. Microcirculation function assessed by adenosine triphosphate stress myocardial contrast echocardiography and prognosis in patients with nonobstructive coronary artery disease[J]. Medicine (Baltimore),2019,98(27):e15990.
[15].Cin VG,Pekdemir H,Camsar A,et al. Diffuse intimal thickening of coronary arteries in slow coronary flow[J].Jpn Heart J,2003,44(6):907.
[16].Yong W,Liu MJ,Yang HM,et al. Association between increased serum alkaline phosphatase and the coronary slow flow phenomenon[J]. Bmc Cardiovasc Disord,2018,18(1):138.
[17].Duntas LH,Brenta G. A renewed focus on the association between thyroid hormones and lipid metabolism[J]. Front Endocrinol (Lausanne),2018,9:511.
[18].刘伟,胡元生,刘梅,等. 甲状腺激素,甲状腺抗体在心血管疾病中的作用及临床价值[J]. 中西医结合心脑血管病杂志,2021,19(9):1549-1551.
[19].Bruschi M,Candiano G,Santucci L,et al. Oxidized albumin. The long way of a protein of uncertain function[J]. Biochim Biophys Acta,2013,1830(12):5473-5479.
[20].Incalza MA,D’Oria R,Natalicchio A,et al. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases[J].Vascul Pharmacol,2018,100:1-19.
[21].张伟,孙中华,米杰,等.冠状动脉慢血流患者危险因素分析及临床随访[J]. 中华急诊医学杂志,2014,23(2):204-208.
[22].Yildiz A,Yilmaz R,Demirbag R,et al. Association of serum uric acid level and coronary blood flow[J]. Coronary Artery Disease,2007,18(8):607-613.
[23].Khosla UM,Zharikov S,Finch JL,et al. Hyperuricemia induces endothelial dysfunction[J]. Kidney Int,2005,67(5):1739-1742.
[24].Breitenstein S,Roessig L,Sandner P,et al.Novel sGC stimulators and sGC activators for the treatment of heart failure[M]. //Bauersachs J,Butler J,Sandner P. Handbook of Experimental Pharmacology. Switzerland:Springer, 2016,243:225-247.

相似文献/References:

[1]任茂佳,贺文帅,张琪,等.围绝经期对心血管疾病相关危险因素的影响[J].心血管病学进展,2019,(6):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
　REN Maojia,HE Wenshuai,ZHANG Qi,et al.Effects of Perimenopause on Cardiovascular Risk Factors[J].Advances in Cardiovascular Diseases,2019,(2):911.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.018]
[2]林莉 韦铁民.急性心肌梗死后心脏破裂[J].心血管病学进展,2019,(7):1039.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.019]
　LIN LiWEI Tiemin.Post-infarction Cardiac Rupture[J].Advances in Cardiovascular Diseases,2019,(2):1039.[doi:10.16806/j.cnki.issn.1004-3934.2019.07.019]
[3]程晓艺,寇秀玲,黄明刚,等.颈动脉斑块与冠状动脉粥样硬化相关性影像学分析[J].心血管病学进展,2019,(6):960.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.030]
　CHENG Xiaoyi,KOU Xiuling,HUANG Minggang,et al.Imaging Analysis of Carotid Plaque and Coronary Artery Atherosclerosis[J].Advances in Cardiovascular Diseases,2019,(2):960.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.030]
[4]潘甜 马康华.急性心肌梗死经皮冠脉介入术后冠状动脉无复流的预防和治疗进展[J].心血管病学进展,2019,(5):730.[doi:10.16806/j.cnki.issn.1004-3932019.05.017]
　PAN Tian,MA Kanghua.Prevention and Treatment of Coronary Artery No-Reflow after Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(2):730.[doi:10.16806/j.cnki.issn.1004-3932019.05.017]
[5]汤月霞 吴宗贵.脂蛋白a用于预测心血管疾病的争议[J].心血管病学进展,2019,(8):1158.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.022]
　TANG Yuexia,WU Zonggui.Controversies about the Use of Lipoprotein() in Predicting Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2019,(2):1158.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.022]
[6]孙静美 尹德春 曲秀芬.炎症信号与心房颤动[J].心血管病学进展,2020,(1):31.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.009]
　SUN Jingmei,YIN Dechun,QU Xiufen.Inflammatory Signals Associated with Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2020,(2):31.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.009]
[7]黄巧娟 周晓莉.冠状动脉慢血流现象的研究进展[J].心血管病学进展,2020,(2):163.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.016]
　HUANG QiaojuanZHOU Xiaoli.Coronary Slow Flow Phenomenon[J].Advances in Cardiovascular Diseases,2020,(2):163.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.016]
[8]秦莉,张艺文,杨晓倩,等.系统性红斑狼疮合并心力衰竭的危险因素及管理[J].心血管病学进展,2020,(3):264.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.012]
　QIN Li,ZHANG Yiwen,YANG Xiaoqian,et al.Risk Factors and Management of Heart Failure in Systemic Lupus Erythematosus[J].Advances in Cardiovascular Diseases,2020,(2):264.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.012]
[9]徐风燕 孙飞龙.非瓣膜性心房颤动患者华法林抗凝质量的临床研究[J].心血管病学进展,2020,(8):868.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.021]
　XU Fengyan,SUN Longfei.(Department of Cardiology,Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 831100,Xinjiang,China)[J].Advances in Cardiovascular Diseases,2020,(2):868.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.021]
[10]游钫,陈新云,蒋小晶,等.正常血压高值人群缺血性心血管疾病发生风险的评估分析[J].心血管病学进展,2020,(10):1091.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.022]
　YOU Fang,CHEN Xinyun,JIANG Xiaojing,et al.Risk Assessment of Ischemic-Cardiovascular Diseases in People with High-Normal Value of Blood Pressure[J].Advances in Cardiovascular Diseases,2020,(2):1091.[doi:10.16806/j.cnki.issn.1004-3934.2020.10.022]

更新日期/Last Update: 2022-08-19