[1]裴瑛 陈建淑 张好东 寇城坤 余静.不同降压药物心血管事件的风险评价:基于贝叶斯模型的网状荟萃 分析[J].心血管病学进展,2021,(12):1142-1147.[doi:10.16806/j.cnki.issn.1004-3934.2021.12.020]
 PEI Ying,CHEN Jianshu,ZHANG Haodong,et al.Risk Assessment of Cardiovascular Events with Different Antihypertensive Drugs: Bayesian Model-based Network Meta Analysis[J].Advances in Cardiovascular Diseases,2021,(12):1142-1147.[doi:10.16806/j.cnki.issn.1004-3934.2021.12.020]
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不同降压药物心血管事件的风险评价:基于贝叶斯模型的网状荟萃 分析()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年12期
页码:
1142-1147
栏目:
论著
出版日期:
2021-12-25

文章信息/Info

Title:
Risk Assessment of Cardiovascular Events with Different Antihypertensive Drugs: Bayesian Model-based Network Meta Analysis
作者:
裴瑛 陈建淑 张好东 寇城坤 余静
(兰州大学第二医院心血管内科,高血压中心,甘肃 兰州 730000)
Author(s):
PEI YingCHEN JianshuZHANG HaodongKOU ChengkunYU Jing
(Department of Cardiology,Lanzhou University Second Hospital,Lanzhou 730000,Gansu, China)
关键词:
高血压降压药物心血管事件网状荟萃
Keywords:
Hypertension Antihypertension drugs Cardiovascular events Network-meta analysis
DOI:
10.16806/j.cnki.issn.1004-3934.2021.12.020
摘要:
目的 比较指南推荐的不同降压药物对心血管事件的影响。 方法 通过计算机检索Pubmed、Em base和Cochrane等数据库,筛选并纳入截止2020年10月比较两种及以上降压药物或安慰剂的随机临床对照试验共32项,其中包括192 036例高血压患者,采用基于贝叶斯模型网状meta分析进行评价。结果 与血管紧张素Ⅱ受体阻滞剂(RR=0.95,95%CI 0.70~0.96)、β受体抑制剂(RR=0.78,95%CI 0.60 ~0.88)、钙离子通道阻滞剂(RR=0.88,95%CI 0.56~0.71)、利尿剂(RR=0.91,95%CI 0.34~0.87)相比较,高血压患者服用血管紧张素转化酶抑制剂发生心血管事件风险更低。结论 使用不同降压药物,发生心血管事件风险不一,其中血管紧张素转化酶抑制剂类降压药物发生心血管事件风险最低,β受体阻滞剂发生心血管事件风险相对较高。
Abstract:
Objective To compare the effects of different antihypertensive drugs on cardiovascular events. Methods We conducted a systemic review of randomized controlled trials published up to October 30,2020 using Embase,Pubmed,and the Cochrane library database. 32 randomized controlled clinical trials comparing two or more antihypertensive drugs or placebo-controlled drugs were screened and included,including 192 036 patients with hypertension. A bayesian model based network-meta analysis was used for systematic analysis and evaluation. Results Comparad with angiotensin receptor blockers(RR=0.95,95%CI 0.70~0.96),β-blockers(RR=0.78,95%CI 0.60~0.88),Calcium channel blockers(RR=0.88,95%CI 0.56~0.71)and diuretics(RR=0.91,95%CI 0.34~0.87),angiotensin converting enzyme inhibitors have a lower risk of cardiovascular events.Conclusion Comparad with the risk of cardiovascular events varies with the use of different antihypertensive drugs,among which angiotensin converting enzyme inhibitors have the lowest risk of cardiovascular events,while beta blockers have a relatively high risk.

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备注/Memo

备注/Memo:
通信作者:余静,E-mail:ery_jyu@lzu.edu.cn?div>收稿日期:2021-03-25
更新日期/Last Update: 2022-01-07