[1]杨锐雪 叶强.沙库巴曲缬沙坦对心力衰竭患者室性心律失常影响的研究进展[J].心血管病学进展,2021,(8):695-697.[doi:1016806/j.cnki.issn.1004-3934.2021.08.006]
 YANG Ruixue YE Qiang.Effects of Sacubitril/valsartan on Ventricular Arrhythmia in Patients with Heart Failure[J].Advances in Cardiovascular Diseases,2021,(8):695-697.[doi:1016806/j.cnki.issn.1004-3934.2021.08.006]
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沙库巴曲缬沙坦对心力衰竭患者室性心律失常影响的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年8期
页码:
695-697
栏目:
综述
出版日期:
2021-08-25

文章信息/Info

Title:
Effects of Sacubitril/valsartan on Ventricular Arrhythmia in Patients with Heart Failure
作者:
杨锐雪1 叶强12
(1.西南医科大学附属医院心血管内科,泸州 6460002 西南医科大学附属医院心血管内科,泸州 646000)
Author(s):
YANG Ruixue1 YE Qiang12
(1.Department of Cardiology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China2. Department of Cardiology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan,China)
关键词:
沙库巴曲缬沙坦心力衰竭室性心律失常
Keywords:
Sacubitril/Valsartan Hear failure Ventricular arrhythmia
DOI:
1016806/j.cnki.issn.1004-3934.2021.08.006
摘要:
心力衰竭(心衰)是所有心血管疾病的终末阶段。心力衰竭可导致室性心律失常增加从而增加死亡率。沙库巴曲缬沙坦是治疗心力衰竭的新药,它能够改善心力衰竭症状、降低住院率及死亡率。研究也发现相比于血管紧张素转酶抑制剂/,沙库巴曲缬沙坦表现出抗室性心律失常的作用。就沙库巴曲缬沙坦对心力衰竭患者室性心律失常影响的研究进展进行综述。
Abstract:
Heart failure is the end-stage manifestation of all cardiovascular diseases Heart failure could lead to increasement of ventricular arrhythmias and mortality. Sacubitril/Valsartan is a new drug for the treatment of heart failure. It can improve the symptoms of heart failure,reduce hospitalization and mortality. Studies have also found that Sacubitril/Valsartan exhibit anti-ventricular arrhythmia effects compared to angiotensin-converting enzyme inhibitors/angiotensin receptor blockers. This article reviews the research progress of the effects of Sacubitril and Valsartan on ventricular arrhythmia in patients with heart failure.

参考文献/References:

[1] Masarone DLimongelli G,Ammendola E,et al. Risk stratification of sudden cardiac death in patients with heart failure:an update[J]. J Clin Med,2018,7(11):436.
[2] Desai AS,McMurray JJV,Packer M,et al. Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients[J]. Eur Heart J,2015,36(30):1990-1997.
[3] Rohde LE,Chatterjee NA,Vaduganathan M,et al. Sacubitril/Valsartan and sudden cardiac death according to implantable cardioverter-defibrillator use and heart?failure cause[J]. JACC Heart Fail,2020,8(10):844-855.
[4] McMurray JJ,Packer M,Desai AS,et al. Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure:rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)[J]. Eur J Heart Fail,2013,15(9):1062-1073.
[5] Xie W,Zheng F,Song X,et al. Renin-angiotensin-aldosterone system blockers for heart failure with reduced ejection fraction or left ventricular dysfunction:Network meta-analysis[J]. Int J Cardiol,2016,205(205):65-71.
[6] Hubers SA,Brown NJ.Combined angiotensin receptor antagonism and neprilysin inhibition[J]. Circulation,2016,133(11):1115-1124.
[7] Ferrari R,Cardoso J,Fonseca MC,et al. ARNIs:balancing "the good and the bad" of neuroendocrine response to HF[J]. Clin Res Cardiol,2020,109(5):599-610.
[8] de Diego C,Gonzalez-Torres L,Nunez JM,et al. Effects of angiotensin-neprilysin inhibition compared to angiotensin inhibition on ventricular arrhythmias in reduced ejection fraction patients under continuous remote monitoring of implantable defibrillator devices[J]. Heart Rhythm,2018,15(3):395-402.
[9] Martens P,Nuyens D,Rivero-Ayerza M,et al. Sacubitril/valsartan reduces ventricular arrhythmias in parallel with left ventricular reverse remodeling in heart failure with reduced ejection fraction[J]. Clin Res Cardiol,2019,108(10):1074-1082.
[10] El-Battrawy I,Pilsinger C,Liebe V,et al. Impact of sacubitril/valsartan on the long-term incidence of ventricular arrhythmias in chronic heart failure patients[J]. J Clin Med,2019,8(10):1582.
[11] Peng S,Lu XF,Qi YD,et al. LCZ696 ameliorates oxidative stress and pressure overload-induced pathological cardiac remodeling by regulating the Sirt3/MnSOD pathway[J]. Oxid Med Cell Longev,2020,2020:9815039.
[12] Iborra-Egea O,Gálvez-Montón C,Roura S,et al. Mechanisms of action of sacubitril/valsartan on cardiac remodeling:a systems biology approach[J]. NPJ Syst Biol Appl,2017,3(1):12.
[13] Burke RM,Lighthouse JK,Mickelsen DM,et al. Sacubitril/valsartan decreases cardiac fibrosis in left ventricle pressure overload by restoring PKG signaling in cardiac fibroblasts[J]. Circ Heart Fail,2019,12(4):e005565.
[14] Valentim Gon?alves A,Pereira-da-Silva T,Galrinho A,et al. Antiarrhythmic effect of sacubitril-valsartan:cause or consequence of clinical improvement?[J]. J Clin Med,2019,8(6):869.
[15] Okutucu S,Sabanoglu C,Yetis Sayin B,et al. Switching from ramipril to sacubitril/valsartan favorably alters electrocardiographic indices of ventricular repolarization in heart failure with reduced ejection fraction[J]. Acta Cardiol,2020,75(1):20-25.
[16] Chang PC,Lin SF,Chu Y,et al. LCZ696 therapy reduces ventricular tachyarrhythmia inducibility in a myocardial infarction-induced heart failure rat model[J]. Cardiovasc Ther,2019,2019:6032631.
[17] Chang PC,Wo HT,Lee HL,et al. Sacubitril/valsartan therapy ameliorates ventricular tachyarrhythmia inducibility in a rabbit myocardial infarction model[J]. J Card Fail,2020,26(6):527-537.
[18] Okutucu S,Oto A. A electrical storm after initiating sacubitril/valsartan:arrhythmic paradox[J]. Cardiology,2019,142(1):24-25.
[19] Vicent L,Juarez M,Martin I,et al. Ventricular arrhythmic storm after initiating sacubitril/valsartan[J]. Cardiology,2018,139(2):119-123.
[20] Vicent L,Juarez M,Bruna V,et al. Clinical profile and ventricular arrhythmias after sacubitril/valsartan initiation[J]. Cardiology,2019,142(1):26-27.

备注/Memo

备注/Memo:
通信作者:叶强,E-mail:qiangye78@126.com 收稿日期:2021-01-17
更新日期/Last Update: 2021-09-26