[1]魏天天?王学超?吴海波?杜荣品.心力衰竭生物标志物的研究进展[J].心血管病学进展,2021,(7):610-613.[doi:10.16806/j.cnki.issn.1004-3934.2021.07.009]
 WEI Tiantian,WANG Xuechao,WU Haibo,et al.Biomarkers of Heart Failure[J].Advances in Cardiovascular Diseases,2021,(7):610-613.[doi:10.16806/j.cnki.issn.1004-3934.2021.07.009]
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心力衰竭生物标志物的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年7期
页码:
610-613
栏目:
出版日期:
2021-07-25

文章信息/Info

Title:
Biomarkers of Heart Failure
作者:
魏天天1?王学超2?吴海波2?杜荣品12
(1.华北理工大学研究生院,河北 唐山 063200;2.华北理工大学附属河北省人民医院心内科,河北 石家庄 050000)
Author(s):
WEI Tiantian1 WANG Xuechao2 WU Haibo2 DU Rongpin12
(1.North China University of Science and Technology Graduate SchoolTangshan 063200HebeiChina2.Department of CardiologyHebei General HospitalNorth China University of Science and TechnologyShijiazhuang 050000HebeiChina)
关键词:
心力衰竭生物标志物心肌细胞纤维化炎症因子微小RNA
Keywords:
Heart failureBiomarkersMyocardial fibrosisInflammatory factorsmicroRNA
DOI:
10.16806/j.cnki.issn.1004-3934.2021.07.009
摘要:
心力衰竭(心衰)目前发病率随人口老龄化而增加,诊断及评估心衰主要包括心肌标志物和心脏超声相关指标。由于心衰病死率高,早期诊断和评估危险分层及预后有着重要意义,而心衰的病理生理过程复杂,涉及到心肌重塑、神经内分泌系统激活和氧化应激等。因此心衰相关标志物的研究对其诊断及治疗有重要意义。
Abstract:
The incidence rate of heart failure increases with aging population. Diagnosis and assessment of heart failure mainly include myocardial markers and echocardiographic related indicators. Due to the high mortality of heart failure,early diagnosis and assessment of risk stratification and prognosis is of great significance. The pathophysiological process of heart failure is complex,involving myocardial remodeling,neuroendocrine system activation,oxidative stress,etc. Therefore,the study of heart failure related markers is of great significance for its diagnosis and treatment

参考文献/References:

[1].Ponikowski P,Voors AA,Anker SD,et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure:the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology(ESC) developed with the special contribution of the Heart Failure Association(HFA) of the ESC[J]. Eur Heart J,2016,37(27):2129-2200.
[2].Sarhene M,Wang Y,Wei J,et al. Biomarkers in heart failure:the past,current and future[J]. Heart Fail Rev,2019,24(6):867-903.
[3].Troughton R,Michael Felker G,Januzzi JL Jr. Natriuretic peptide-guided heart failure management[J]. Eur Heart J,2014,35(1):16-24.
[4].R?rth R,Jhund PS,Yilmaz MB,et al. Comparison of BNP and NT-proBNP in patients with heart failure and reduced ejection fraction[J]. Circ Heart Fail,2020,13(2):e006541.
[5].Sbolli M,deFilippi C. BNP and NT-proBNP interpretation in the neprilysin inhibitor era[J]. Curr Cardiol Rep,2020,22(11):150.
[6].Rapatz K,Finsterer J,Voill-Glaninger A,et al. NT-pro-BNP in patients with left ventricular hypertrabeculation/non-compaction[J]. ESC Heart Fail,2020,7(6):4126-4133.
[7].Reginauld SH,Sangaralingham SJ,Iyer SR,et al. ANP production is impaired in acute decompensated heart failure[J]. J Card Fail,2020,26(10):s19.
[8].Davidovski FS,Goetze JP. ProANP and proBNP in plasma as biomarkers of heart failure[J]. Biomark Med,2019,13(13):1129-1135.
[9].Kriechbaum SD,Wiedenroth CB,Peters K,et al. Galectin-3,GDF-15,and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension[J]. Biomarkers,2020,25(7):578-586.
[10].Homsak E,Gruson D. Soluble ST2:a complex and diverse role in several diseases[J]. Clin Chim Acta,2020,507:75-87.
[11].Song Y,Li F,Xu Y,et al. Prognostic value of sST2 in patients with heart failure with reduced,mid-range and preserved ejection fraction[J]. Int J Cardiol,2020,304:95-100.
[12].Pourafkari L,Tajlil A,Nader ND,et al. Biomarkers in diagnosing and treatment of acute heart failure[J]. Biomark Med,2019,13(14):1235-1249.
[13].Kanukurti J,Mohammed N,Sreedevi NN,et al. Evaluation of galectin-3 as a novel diagnostic biomarker in patients with heart failure with preserved ejection fraction[J]. J Lab Physicians,2020,12(2):126-132.
[14].Komici K,Gnemmi I,Bencivenga L,et al. Impact of galectin-3 circulating levels on frailty in elderly patients with systolic heart failure[J]. J Clin Med,2020,9(7):2229.
[15].Wang N,Dang M,Zhang W,et al.Galectin-3 is associated with severe heart failure and death:a hospital-based study in Chinese patients[J]. Scand J Immunol,2020,91(5):e12826.
[16].Chen H,Chen C,Fang J,et al. Circulating galectin-3 on admission and prognosis in acute heart failure patients:a meta-analysis[J]. Heart Fail Rev,2020,25(2):331-341.
[17].Krebber MM,van Dijk CGM,Vernooij RWM,et al. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in extracellular matrix remodeling during left ventricular diastolic dysfunction and heart failure with preserved ejection fraction:a systematic review and meta-analysis[J]. Int J Mol Sci,2020,21(18):6742.
[18].Suthahar N,Meems LMG,Ho JE,et al. Sex-related differences in contemporary biomarkers for heart failure:a review[J]. Eur J Heart Fail,2020,22(5):775-788.
[19].Jordakieva G,Budge-Wolfram RM,Budinsky AC,et al. Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival[J]. Wien Klin Wochenschr,2021,133(3-4):86-95.
[20].Manka SW,Bihan D,Farndale RW. Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling[J]. Sci Rep,2019,9(1):18785.
[21].Lijnen PJ,Maharani T,Finahari N,et al. Serum collagen markers and heart failure[J]. Cardiovasc Haematol Disord Drug Targets,2012,12(1):51-55.
[22].Kociol RD,Pang PS,Gheorghiade M,et al. Troponin elevation in heart failure[J]. J Am Coll Cardiol,2010,56(14):1071-1078.
[23].Tang O,Matsushita K,Coresh J,et al. High-sensitivity cardiac troponin I and T for cardiovascular risk stratification in adults with diabetes[J]. Diabetes Care,2020,43(10):e144-e146.
[24].Yan I,B?rschel CS,Neumann JT,et al. High-sensitivity cardiac troponin I levels and prediction of heart failure:results from the BiomarCaRE consortium[J]. JACC Heart Fail,2020,8(5):401-411.
[25].Coldren WH,Tikunova SB,Davis JP,et al. Discovery of novel small-molecule calcium sensitizers for cardiac troponin C:a combined virtual and experimental screening approach[J]. J Chem Inf Model,2020,60(7):3648-3661.
[26].Goel H,Melot J,Krinock MD,et al. Heart-type fatty acid-binding protein an overlooked cardiac biomarker[J]. Ann Med,2020,52(8):444-461.
[27].Otaki Y,Watanabe T,Kubota I. Heart-type fatty acid-binding protein in cardiovascular disease:a systemic review[J]. Clin Chim Acta,2017,474:44-53.
[28].[28] Lakhani I,Wong MV,Hung JKF,et al. Diagnostic and prognostic value of serum C-reactive protein in heart failure with preserved ejection fraction:a systematic review and meta-analysis[J]. Heart Fail Rev,2020 Feb 6.DOI: 10.1007/s10741-020-09927-x.?Online ahead of print.
[29].[29] Sabbah MS,Fayyaz AU,de Denus S,et al. Obese-inflammatory phenotypes in heart failure with preserved ejection fraction[J]. Circ Heart Fail,2020,13(8):e006414.
[30].[30] DuBrock HM,AbouEzzeddine OF,Redfield MM. High-sensitivity C-reactive protein in heart failure with preserved ejection fraction[J]. PLoS One,2018,13(8):e0201836.
[31].[31] Hanna A,Frangogiannis NG. Inflammatory cytokines and chemokines as therapeutic targets in heart failure[J]. Cardiovasc Drugs Ther,2020,34(6):849-863.
[32].[32] Warbrick I,Rabkin SW. Hypoxia-inducible factor 1-alpha (HIF-1α) as a factor mediating the relationship between obesity and heart failure with preserved ejection fraction[J]. Obes Rev,2019,20(5):701-712.
[33].[33] Jin Y,Kong D,Liu C,et al. Role of IL-33 in transplant biology[J]. Eur Cytokine Netw,2019,30(2):39-42.
[34].[34] Ghali R,Altara R,Louch WE,et al. IL-33(interleukin 33)/sST2 axis in hypertension and heart failure[J]. Hypertension,2018,72(4):818-828.
[35].[35] Arfsten H,Cho A,Freitag C,et al. GDF-15 in solid vs non-solid treatment-na?ve malignancies[J]. Eur J Clin Invest,2019,49(11):e13168.
[36].[36] Bettencourt P,Ferreira-Coimbra J,Rodrigues P,et al. Towards a multi-marker prognostic strategy in acute heart failure:a role for GDF-15[J]. ESC Heart Fail,2018,5(6):1017-1022.
[37].[37] Jirak P,Pistulli R,Lichtenauer M,et al. Expression of the novel cardiac biomarkers sST2,GDF-15,suPAR,and H-FABP in HFpEF patients compared to ICM,DCM,and controls[J]. J Clin Med,2020,9(4):1130.
[38].[38] Chaikijurajai T,Tang WHW. Reappraisal of inflammatory biomarkers in heart failure[J]. Curr Heart Fail Rep,2020,17(1):9-19.
[39].[39] Medvedeva EA,Berezin II,Shchukin YV,et al. Galectin-3,markers of oxidative stress and renal dysfunction in patients with chronic heart failure[J]. Kardiologiia,2017,57(3):46-50.
[40].[40] Li M,Duan L,Li Y,et al. Long noncoding RNA/circular noncoding RNA-miRNA-mRNA axes in cardiovascular diseases[J]. Life Sci,2019,233:116440.
[41].[41] Cruz MS,da Silva AMG,de Souza KSC,et al. miRNAs emerge as circulating biomarkers of post-myocardial infarction heart failure[J]. Heart Fail Rev,2020,25(2):321-329.
[42].[42] Sygitowicz G,Maciejak-Jastrz?bska A,Sitkiewicz D. MicroRNAs in the?development of left ventricular remodeling and postmyocardial infarction heart failure[J]. Pol Arch Intern Med,2020,130(1):59-65.
[43].[43] Wang Y,Liang Y,Zhao W,et al. Circulating miRNA-21 as a diagnostic biomarker in elderly patients with type 2 cardiorenal syndrome[J]. Sci Rep,2020,10(1):4894.

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备注/Memo

备注/Memo:
收稿日期:2020-11-12基金项目:河北省科学技术厅(20377774D)
更新日期/Last Update: 2021-09-10