[1]杭成文 崔鸣.Myomesin基因家族及其相关疾病的研究进展[J].心血管病学进展,2021,(4):314-317.[doi:10.16806/j.cnki.issn.1004-3934.2021.04.007]
 HANG Chengwen,CUI Ming.Myomesin Gene Family and Related Diseases[J].Advances in Cardiovascular Diseases,2021,(4):314-317.[doi:10.16806/j.cnki.issn.1004-3934.2021.04.007]
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Myomesin基因家族及其相关疾病的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年4期
页码:
314-317
栏目:
综述
出版日期:
2021-04-25

文章信息/Info

Title:
Myomesin Gene Family and Related Diseases
作者:
杭成文 崔鸣
成文 崔鸣 (北京大学第三医院心内科,北京 100191)
Author(s):
HANG ChengwenCUI Ming
(Department of Cardiology,Peking University Third Hospital,Beijing 100191,China)
关键词:
M带Myomesin家族肌肉疾病心肌病肌节
Keywords:
M-bandMyomesin gene familyMyopathyCardiomyopathy Sarcomere
DOI:
10.16806/j.cnki.issn.1004-3934.2021.04.007
摘要:
随着近年来对横纹肌肌原纤维M带的研究深入,人们发现M带异常也是导致肌肉疾病发生的重要原因。其中肌间蛋白(Myomesin)基因家族(主要包括MYOM1、MYOM2和MYOM3)编码的蛋白是目前已知的心肌和骨骼肌肌原纤维M带中央部M线的主要组成成分。现对其分子组成、生理功能以及与疾病的关联进行综述,突出其重要性,从而引起研究者的重视。
Abstract:
With the in-depth research on the M-band of striated muscle myofibrils in recent years, it has been found that abnormalities in the M-band are also an important cause of myopathies. The proteins encoded by Myomesin gene family (mainly including MYOM1 , MYOM2 and MYOM3) are currently known as one of the main structural components of the M-line , locating in the central part of the M-band in myocardium and skeletal muscle. This article will review its molecular composition, biological function and its association with diseases, so as to highlight its importance and get researchers’ attention to this gene family.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目:国家自然基金面上项目(81570235);北京市自然科学基金面上项目(7202225) 通信作者:崔鸣,E-mail:mingcui@bjmu.edu.cn 收稿日期:2020-08-29
更新日期/Last Update: 2021-07-01