[1]魏伟 魏灵睿 冷辉.血清miR-1和miR-26水平与川崎病患儿的关系及其对冠状动脉损伤的评估价值[J].心血管病学进展,2021,(5):476-480.[doi:10.16806/j.cnki.issn.1004-3934.2021.05.021]
　WEI WeiWEI LingruiLENG Hui.Relationship Between Serum miR-1 and miR-26 Levels and Kawasaki Disease in Children and Its Value in Evaluating Coronary Artery Injury[J].Advances in Cardiovascular Diseases,2021,(5):476-480.[doi:10.16806/j.cnki.issn.1004-3934.2021.05.021]
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血清miR-1和miR-26水平与川崎病患儿的关系及其对冠状动脉损伤的评估价值()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年5期
页码:
476-480
栏目:
论著
出版日期:
2021-05-25

文章信息/Info

Title:
Relationship Between Serum miR-1 and miR-26 Levels and Kawasaki Disease in Children and Its Value in Evaluating Coronary Artery Injury
作者:
魏伟1 魏灵睿2 冷辉3
(1.湖北省随州市中心医院儿科,湖北 随州 441300;2.湖北大学生命科学学院,湖北 武汉 430062;3.湖北省随州市中心医院病案统计科,湖北 随州 441300)
Author(s):
WEI Wei1WEI Lingrui2LENG Hui3
?ediatric Department , Hubei Suizhou Central Hospital, Suizhou 441300, Hubei ,China; 2. Hubei University School of Life Sciences,Wuhan 430062,Hubei China; 3. Medical Records Statistics Division,Hubei Suizhou Central Hospital, Suizhou 441300, Hubei,China)
关键词:
川崎病; miR-1; miR-26
Keywords:
Kawasaki disease; miR-1; miR-26
DOI:
10.16806/j.cnki.issn.1004-3934.2021.05.021
摘要:
目的 分析血清miR-1和miR-26水平与川崎病（KD）患儿的关系及其对冠状动脉损伤（CAL）的评估价值。方法 选择2016年1月—2019年12月湖北省随州市中心医院收治的92例KD患儿，根据患者的CAL发生情况，将其分为CAL组（n=32）和无CAL（NCAL）组（n=60），另选取同期于该院体检的46例儿童为对照组。分别于治疗的急性期和恢复期，采用荧光定量PCR检测血清miR-1和miR-26水平，彩色多普勒超声诊断仪检查冠状动脉内径；Pearson相关性分析血清miR-1和miR-26水平与冠状动脉内径之间的关系；接受者操作特征曲线分析血清miR-1和miR-26水平对CAL发生的预测价值。结果 KD患儿急性期和恢复期的血清miR-1和miR-26水平明显低于对照组（P＜0.05），冠状动脉内径明显高于对照组（P＜0.05），急性期血清miR-1和miR-26水平明显低于恢复期（P＜0.05），冠状动脉内径明显高于恢复期（P＜0.05）；CAL组KD患儿急性期和恢复期血清miR-1和miR-26水平明显低于NCAL组（P＜0.05），冠状动脉内径明显高于NCAL组（P＜0.05），且随着CAL分级增加， KD患儿急性期和恢复期的血清miR-1 和miR-26水平明显降低（P＜0.05），冠状动脉内径明显升高（P＜0.05）；血清miR-1和miR-26水平与冠状动脉内径呈显著的负相关关系（r=－0.367，－0.391；P＜0.05）；血清miR-1和miR-26与联合检测预测CAL发生的曲线下面积依次为0.817、0.854和0.930。结论 KD患儿血清miR-1和miR-26水平与冠状动脉内径有关，可用于临床预测CAL的发生，指导临床治疗。
Abstract:
Objective To analyze the relationship between serum miR-1 and miR-26 levels and Kawasaki disease(KD) in children and its value in evaluating coronary artery injury(CAL). Methods A total of 92 children with KD who were admitted to the hospital from January 2016 to December 2019 were enrolled. They were divided into CAL group(n=32) and NCAL group(n=60) a ccording to the occurrence of CAL. Another 46 children who underwent physical examination in the hospital during the same period were enrolled as control group. During acute and recovery period of treatment,levels of serum miR-1 and miR-26 were detected by fluorescence quantitative PCR. Th e inner diameters of coronary arteries were examined by color Doppler ultrasound diagnostic apparatus. Relationship between serum miR-1 and miR-26 levels and inner diameters of coronary arteries was analyzed by Pearson correlation analysis. The predictive value of serum miR-1 and miR-26 levels in CAL was analyzed by ROC curves. Results During acute and recovery period, levels of serum miR-1 and miR-26 in KD children were significantly lower than those in control group(P<0.05), while inner diameters of coronary arteries were significantly higher than those in control group(P<0.05). The levels of serum miR-1 and miR-26 during acute period were significantly lower than those during recovery period(P<0.05),while inner diameters of coronary arteries were significantly higher than those during recovery period(P<0.05). During acute and recovery period, levels of serum miR-1 and miR-26 in CAL group were significantly lower than those in NCAL group(P<0.05),while inner diameters of coronary arteries were significantly higher than those in NCAL group(P<0.05). With the increase of CAL grade, levels of serum miR-1 and miR-26 in acute and recovery period in KD children were significantly decreased (P<0.05),and the inner diameter of coronary arteries was significantly increased (P<0.05). The levels of serum miR-1 and miR-26 were significantly negatively correlated with inner diameters of coronary arteries (r=－0.367,－0.391;P<0.05). AUCs of serum miR-1 and miR-26 and their combination for predicting CAL were 0.817, 0.854 and 0.930, respectively. Conclusion The levels of serum miR-1 and miR-26 are related to inner diameters of coronary arteries in KD children,which can be applied to predict occurrence of CAL and guide clinical treatment

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更新日期/Last Update: 2021-06-16