[1]魏伟 魏灵睿 冷辉.血清miR-1和miR-26水平与川崎病患儿的关系及其对冠状动脉损伤的评估价值[J].心血管病学进展,2021,(5):476-480.[doi:10.16806/j.cnki.issn.1004-3934.2021.05.021]
 WEI WeiWEI LingruiLENG Hui.Relationship Between Serum miR-1 and miR-26 Levels and Kawasaki Disease in Children and Its Value in Evaluating Coronary Artery Injury[J].Advances in Cardiovascular Diseases,2021,(5):476-480.[doi:10.16806/j.cnki.issn.1004-3934.2021.05.021]
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血清miR-1和miR-26水平与川崎病患儿的关系及其对冠状动脉损伤的评估价值()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年5期
页码:
476-480
栏目:
论著
出版日期:
2021-05-25

文章信息/Info

Title:
Relationship Between Serum miR-1 and miR-26 Levels and Kawasaki Disease in Children and Its Value in Evaluating Coronary Artery Injury
作者:
魏伟1 魏灵睿2 冷辉3
(1.湖北省随州市中心医院儿科,湖北 随州 441300;2.湖北大学生命科学学院,湖北 武汉 430062;3.湖北省随州市中心医院病案统计科,湖北 随州 441300)
Author(s):
WEI Wei1WEI Lingrui2LENG Hui3
?ediatric Department , Hubei Suizhou Central Hospital, Suizhou 441300, Hubei ,China; 2. Hubei University School of Life Sciences,Wuhan 430062,Hubei China; 3. Medical Records Statistics Division,Hubei Suizhou Central Hospital, Suizhou 441300, Hubei,China)
关键词:
川崎病miR-1miR-26
Keywords:
Kawasaki diseasemiR-1miR-26
DOI:
10.16806/j.cnki.issn.1004-3934.2021.05.021
摘要:
目的 分析血清miR-1和miR-26水平与川崎病(KD)患儿的关系及其对冠状动脉损伤(CAL)的评估价值。方法 选择2016年1月—2019年12月湖北省随州市中心医院收治的92例KD患儿,根据患者的CAL发生情况,将其分为CAL组(n=32)和无CAL(NCAL)组(n=60),另选取同期于该院体检的46例儿童为对照组。分别于治疗的急性期和恢复期,采用荧光定量PCR检测血清miR-1和miR-26水平,彩色多普勒超声诊断仪检查冠状动脉内径;Pearson相关性分析血清miR-1和miR-26水平与冠状动脉内径之间的关系;接受者操作特征曲线分析血清miR-1和miR-26水平对CAL发生的预测价值。结果 KD患儿急性期和恢复期的血清miR-1和miR-26水平明显低于对照组(P<0.05),冠状动脉内径明显高于对照组(P<0.05),急性期血清miR-1和miR-26水平明显低于恢复期(P<0.05),冠状动脉内径明显高于恢复期(P<0.05);CAL组KD患儿急性期和恢复期血清miR-1和miR-26水平明显低于NCAL组(P<0.05),冠状动脉内径明显高于NCAL组(P<0.05),且随着CAL分级增加, KD患儿急性期和恢复期的血清miR-1 和miR-26水平明显降低(P<0.05),冠状动脉内径明显升高(P<0.05);血清miR-1和miR-26水平与冠状动脉内径呈显著的负相关关系(r=-0.367,-0.391;P<0.05);血清miR-1和miR-26与联合检测预测CAL发生的曲线下面积依次为0.817、0.854和0.930。结论 KD患儿血清miR-1和miR-26水平与冠状动脉内径有关,可用于临床预测CAL的发生,指导临床治疗。
Abstract:
Objective To analyze the relationship between serum miR-1 and miR-26 levels and Kawasaki disease(KD) in children and its value in evaluating coronary artery injury(CAL). Methods A total of 92 children with KD who were admitted to the hospital from January 2016 to December 2019 were enrolled. They were divided into CAL group(n=32) and NCAL group(n=60) a ccording to the occurrence of CAL. Another 46 children who underwent physical examination in the hospital during the same period were enrolled as control group. During acute and recovery period of treatment,levels of serum miR-1 and miR-26 were detected by fluorescence quantitative PCR. Th e inner diameters of coronary arteries were examined by color Doppler ultrasound diagnostic apparatus. Relationship between serum miR-1 and miR-26 levels and inner diameters of coronary arteries was analyzed by Pearson correlation analysis. The predictive value of serum miR-1 and miR-26 levels in CAL was analyzed by ROC curves. Results During acute and recovery period, levels of serum miR-1 and miR-26 in KD children were significantly lower than those in control group(P<0.05), while inner diameters of coronary arteries were significantly higher than those in control group(P<0.05). The levels of serum miR-1 and miR-26 during acute period were significantly lower than those during recovery period(P<0.05),while inner diameters of coronary arteries were significantly higher than those during recovery period(P<0.05). During acute and recovery period, levels of serum miR-1 and miR-26 in CAL group were significantly lower than those in NCAL group(P<0.05),while inner diameters of coronary arteries were significantly higher than those in NCAL group(P<0.05). With the increase of CAL grade, levels of serum miR-1 and miR-26 in acute and recovery period in KD children were significantly decreased (P<0.05),and the inner diameter of coronary arteries was significantly increased (P<0.05). The levels of serum miR-1 and miR-26 were significantly negatively correlated with inner diameters of coronary arteries (r=-0.367,-0.391;P<0.05). AUCs of serum miR-1 and miR-26 and their combination for predicting CAL were 0.817, 0.854 and 0.930, respectively. Conclusion The levels of serum miR-1 and miR-26 are related to inner diameters of coronary arteries in KD children,which can be applied to predict occurrence of CAL and guide clinical treatment

参考文献/References:

[1].Agarwal S,Agrawal D. Kawasaki disease:etiopathogenesis and novel treatment strategies[J]. Expert Rev Clin Immunol,2016,13(3):247-258.
[2].Yoshida M,Oana S,Masuda H,et al. Recurrence of fever after initial intravenous immunoglobulin treatment in children with Kawasaki disease[J]. Clin Pediatr,2017,57(2):189-192.
[3].Okuma Y,Suda K,Nakaoka H,et al. Serum tenascin-C as a novel predictor for risk of coronary artery lesion and resistance to intravenous immunoglobulin in Kawasaki disease—a multicenter retrospective study[J]. Circ J,2016,80(11):2376-2381.
[4].Kim MK,Song MS,Kim GB. Factors predicting resistance to intravenous immunoglobulin treatment and coronary artery lesion in patients with Kawasaki disease:analysis of the Korean nationwide multicenter survey from 2012 to 2014[J]. Korean Circ J,2018,48(1):71-79.
[5].Mingardi J,Musazzi L,de Petro G,et al. miRNA editing:new insights into the fast control of gene expression in health an d di sease[J]. Mol Neurobiol,2018,55(3):1-11.
[6].Icli B,Dorbala P,Feinberg M. An emerging role for the miR-26 family in cardiovascular disease[J]. Trends Cardiovasc Med,2014,24(6):241-248.
[7].Pinchi E,Frati P,Aromatario M,et al. miR-1,miR-499 and miR-208 are sensitive markers to diagnose sudden death due to early acute myocardial infarction[J]. J Cell Mol Med ,2019,23(9):6005-6016.
[8].Ogawa S,Ayusawa M,Fukazawa R,et al. Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2013) - Digest Version[J]. Circ J, 2014,78(10):2521-2562.
[9].Research Committee of the Japanese Society of Pediatric Cardiology,Cardiac Surgery Committee for Development of Guidelines for Medical Treatment of Acute Kawasaki Disease. Guidelines for medical treatment of acute Kawasaki disease:report of the research committee of the Japanese Society of Pediatric Cardiology and Cardiac Surgery(2012 revised version)[J]. Pediatr Int,2014,56(2):135-158.
[10].Levine GN,Bates ER,Bittl JA,et al. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease[J]. Circulation,2016,134(10):123-155.
[11].Chen K,Curtis N,Dahdah, N,et al. Kawasaki disease and cardiovascular risk:a comprehensive review of subclinical vascular changes in the longer term[J]. Acta Paediatr,2016,105(7):752-761.
[12].Okubo Y,Nochioka K,Sakakibara H,et al. National survey of pediatric hospitalizations due to Kawasaki disease and coronary artery aneurysms in the USA[J]. Clin Rheumatol,2016,36(2):413-419.
[13].Ammirati E,Burns J,Moreo A,et al. Extreme giant aneurysms of three coronary arteries causing heart failure as late sequelae of Kawasaki disease[J]. Eur Heart J,2017,38(10):759-760.
[14].Lauschke V,Vorrink S,Moro S,et al. Massive rearrangements of cellular miRNA signatures are key drivers of hepatocyte dedifferentiation[J]. Hepatology,2016,64(5):1743-1756.
[15].Su T,Shao X,Zhang X,et al. Initial concentrations of miR-1 microRNA precursor and high-sensitivity troponin in the diagnosis of non- ST m yocardial infarction among patients with and those without chronic kidney disease[J]. Cardiorenal Med,2019,9(5):274-283.
[16].Lu S,Lu Y. MiR-26a inhibits myocardial cell apoptosis in rats with acute myocardial infarction through GSK-3β pathway[J]. Eur Rev Med Pharmacol Sci,2020,24(5):2659-2666.
[17].Li S,Ma X,Ji J,et al. miR-1 association with cell proliferation inhibition and apoptosis in vestibular schwannoma by targeting VEGFA[J]. Genet Mol Res,2016,15(4):1-8.
[18].Lu J,Zhao F,Peng Z,et al. EZH2 promotes angiogenesis through inhibition of miR-1/endothelin-1 axis in nasopharyngeal carcinoma[J]. Oncotarget,2014,5(22):11319-11332.
[19].Yan J,Wang H,Gao LX. Diagnostic value of serum miR-1 in patients with acute Kawasaki disease[J]. Clin Lab,2019,65(7). DOI:10.7754/Clin.Lab.2019.190339.
[20].Zhou Y,Wang S,Zhao J,et al. Correlations of complication with coronary arterial lesion with VEGF,PLT,D-dimer and inflammatory factor in child patients with Kawasaki disease[J]. Eur Rev Med Pharmacol Sci,2018,22(16):5121-5126.
[21].Chen C,Chang J,Ho Y,et al. MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1[J]. Nucleic Acids Res,2016,44(8):3772-3787.
[22].Tian J,An X,Niu L. Correlation between NF-κB signal pathway-mediated caspase-4 activation and Kawasaki disease[J]. Exp Ther Med,2017,13(6):3333-3336.

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更新日期/Last Update: 2021-06-16