[1]秦莉 杨晓倩 张艺文 汪汉.基于网络药理学的甘草治疗新型冠状病毒感染合并心肌炎作用机制研究[J].心血管病学进展,2020,(11):1215-1221.[doi:10.16806/j.cnki.issn.1004-3934.2020.11.000]
　QIN Li,YANG Xiaoqian,ZHANG Yiwen,et al.Glycyrrhiza Uralenesis on Novel Coronavirus Infection Complicated with Myocarditis Based on Network Pharmacology[J].Advances in Cardiovascular Diseases,2020,(11):1215-1221.[doi:10.16806/j.cnki.issn.1004-3934.2020.11.000]
点击复制

基于网络药理学的甘草治疗新型冠状病毒感染合并心肌炎作用机制研究()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年11期
页码:
1215-1221
栏目:
论著
出版日期:
2020-11-25

文章信息/Info

Title:
Glycyrrhiza Uralenesis on Novel Coronavirus Infection Complicated with Myocarditis Based on Network Pharmacology
文章编号:
202003028
作者:
秦莉 杨晓倩 张艺文 汪汉
(西南交通大学医学院 西南交通大学附属医院 成都市第三人民医院心内科,四川 成都 610031)
Author(s):
QIN Li;  YANG Xiaoqian;  ZHANG Yiwen;  WANG Han
(Department of Cardiology,The Third Peoples Hospital of Chengdu,Southwest Jiaotong University Medical School,The Affiliated Hospital of Southwest Jiaotong University,Chengdu 610031,Sichuan,China) E-mail7972348@qq.com
关键词:
甘草; 新型冠状病毒合并心肌炎; 网络药理学; 作用机制
Keywords:
Glycyrrhiza uralenesis;  Novel coronavirus infection complicated with myocarditis;  Network pharmacology;  Mechanism
DOI:
10.16806/j.cnki.issn.1004-3934.2020.11.000
摘要:
目的 基于网络药理学探索甘草作用于新型冠状病毒感染合并心肌炎的主要活性成分及作用机制。 方法 利用 TCMSP数据库对甘草的主要活性成分及其靶点筛选，再运用GeneCards数据库和OMIM数据库筛选新型冠状病毒感染合并心肌炎的相关靶点，最后对药物靶点和疾病靶点进行Venn分析，得到甘草作用于新型冠状病毒感染合并心肌炎的交集靶点。利用STRING数据库对交集靶点进行蛋白互作网络分析并筛选关键靶点。采用Cytoscape3.7.2软件构建“药物-活性成分-靶点-疾病”网络图，对靶点基因进行基因本体富集分析和京都基因与基因组百科全书通路分析。 结果 经筛选得到 甘草作用于新型冠状病毒感染合并心肌炎的活性成分71个，作用靶点37个，主要涉及66个生物学过程，156条通路。 结论 本研究初步验证甘草可通过多成分、多靶点和多通路来发挥治疗新型冠状病毒感染合并心肌炎的作用。
Abstract:
Objective To explore the main active components and mechanism of Glycyrrhiza uralenesis on novel coronavirus infection complicated with myocarditis based on network pharmacology. Methods The main active components and targets of Glycyrrhiza uralenesis were screened by TCMSP database, and the targets of novel coronavirus infection complicated with myocarditis were screened by GeneCards database and OMIM database. Finally, the intersection targets of Glycyrrhiza uralenesis were obtained by Venn analysis of drug targets and disease targets. The STRING database was used to analysis the protein interaction network of the intersection targets and screen the key targets. The network map of “drug-active ingredient-target-disease” was constructed by Cytoscape software, and the target genes were analyzed by GO enrichment analysis and KEGG pathway analysis. Results 71 active components and 37 targets were treated with Glycyrrhiza uralenesis, which mainly involved 66 biological processes and 156 signaling pathways. Conclusion This study preliminarily verified that Glycyrrhiza uralenesis can play a role in the treatment of novel coronavirus infection complicated with myocarditis through multiple active components, targets and pathways.

参考文献/References:


[1]Zhou P,Yang XL,Wang XG,et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin[J]. Nature,2020,579(7798):270-273.

[2]郭栋,郭万刚,刘鹏云,等. 新型冠状病毒感染的心脏表现[J].?心脏杂志,2020,32(1):75-77.

[3]高树明,马英,杨丰文,等. 中医药在防治新型冠状病毒肺炎全过程发挥作用[J].?天津中医药,2020,37(2):121-124.

[4]孙立丽,游广娇,任晓亮,等. 甘草化学成分快速定性分析与化学模式识别研究[J].?中华中医药杂志,2018,33(5):2074-2079.

[5]Cinatl J,Morgenstern B,Bauer G,et al. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus[J]. Lancet, 2003,361(9374):2045- 2046.

[6]秦裕辉,胡方林,葛金文. 新冠系列方预防新型冠状病毒感染用方探讨[J]. 湖南中医药大学学报, 2020,40(2):129- 133.

[7]劳慧敏,张葆青,李燕宁. 基于中医传承辅助平台的中医药治疗小儿病毒性心肌炎用药规律分析[J]. 中华中医药学刊,2017,35(3):547-550.

[8]Hopkins AL. Network pharmacology:the next paradigm in drug discovery[J]. Nat Chem Biol,2008,4(11):682-690.

[9]Chen H,Du Q. Potential natural compounds for preventing 2019-nCoV infection[J].Preprints,2020,2020010358.

[10]杨秀伟.甘草酸的抗病毒作用[J]. 中国现代中药,2020,22(4):533-541.

[11]Menegazzi M,di Paola R,Mazzon E,et al. Glycyrrhizin attenuates the development of carrageenan-induced lung injury in mice[J]. Pharmacol Res,2008,58(1):22-31.

[12]Oudit GY,Kassiri Z,Jiang C,et al. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS[J]. Eur J Clin Invest,2009,39(7):618-625.

[13]许冬玉,许玉龙,王至婉,等. 基于网络药理学研究清肺排毒汤治疗新型冠状病毒肺炎的作用机制[J]. 中药药理与临床,2020,36(1):26-32.

[14]Takashima K,Matsushima M,Hashimoto K,et al. Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury[J]. Respir Res,2014,15(1):150.

[15]Mir IA,Tiku AB. Chemopreventive and therapeutic potential of "naringenin," a flavanone present in citrus fruits[J].Nutr Cancer,?2015,67(1):27-42.

[16]Zhao M,Li C,Shen F,et al. Naringenin ameliorates LPS-induced acute lung injury through its anti-oxidative and anti-inflammatory activity and by inhibition of the PI3K/AKT pathway[J].Exp Ther Med,2017,14(3):2228-2234.

[17]上官娇玲,凌智瑜. 心血管疾病风险指标新进展[J]. 心血管病学进展,2019,40(2):199-203.

[18]Wang C,Liu H,Luo J,et al. HA triggers the switch from MEK1 SUMOylation to phosphorylation of the ERK pathway in influenza A virus-infected cells and facilitates its infection[J]. Front Cell Infect Microbiol,2017,7:27.

[19]Liu J,Wang F,Yin D,et al. Caspase 3 may participate in the anti-tumor immunity of dendritic cells[J]. Biochem B iophys R es C ommun,2019,511(2):447-453.

[20]Jandeleit-Dahm K,Watson A,Soro-Paavonen A. The AGE/RAGE axis in diabetes-accelerated atherosclerosis[J]. Clin Exp Pharmacol Physiol, 2008,35(3):329- 334.

[21]Piperi C,Goumenos A,Adamopoulos C,et al. AGE/RAGE signalling regulation by miRNAs:associations with diabetic complications and therapeutic potential[J]. Int J Biochem Cell Biol,2015,60:197-201.

[22]Wang B,Chen L,Dai L,et al. Alisol B 23-acetate ameliorates lipopolysaccharide-induced cardiac dysfunction by suppressing Toll-like receptor 4 (TLR4)/NADPH oxidase 2(NOX2) signaling pathway[J]. Med Sci Monit, 2019,25:8472-8481.

相似文献/References:

[1]唐超 蔡琳 张艺文 汪汉.基于网络药理学的血必清注射液治疗新型冠状病毒感染合并心肌炎的作用机制研究[J].心血管病学进展,2021,(1):86.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]
　TANG Chao,CAI Lin,ZHANG Yiwen,et al.Mechanisms and Active Ingredients of Xuebiqing Injection Affecting Novel Coronavirus Infection Complicated with Myocarditis Based on Network Pharmacology[J].Advances in Cardiovascular Diseases,2021,(11):86.[doi:10.16806/j.cnki.issn.1004-3934.2021.01.000]

更新日期/Last Update: 2021-02-04