[1]狄秀婷 魏士雄 张少伟 田宇 张玉海 张安玲.红细胞分布宽度对感染性心内膜炎患者术后死亡的预测价值[J].心血管病学进展,2020,(7):775-781.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.024]
　DI Xiuting,WEI Shixiong,ZHANG Shaowei,et al.Predictive Value of Red Blood Cell Distribution Width for Postoperative Death of Patients with Infective Endocarditis[J].Advances in Cardiovascular Diseases,2020,(7):775-781.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.024]
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红细胞分布宽度对感染性心内膜炎患者术后死亡的预测价值()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年7期
页码:
775-781
栏目:
出版日期:
2020-07-25

文章信息/Info

Title:
Predictive Value of Red Blood Cell Distribution Width for Postoperative Death of Patients with Infective Endocarditis
作者:
狄秀婷 魏士雄 张少伟 田宇 张玉海 张安玲
(1.聊城市中医医院重症医学科,山东 聊城 252000;2.中国人民解放军总医院心血管外科,北京100853;3.联勤保障部队第989医院心胸大血管外科,河南 洛阳 471000;4.中国人民解放军总医院外科临床部,北京100853;5.内蒙古医科大学包头临床医学院,内蒙古 包头 014000; 6.吉林省一汽总医院,吉林 长春 100853)
Author(s):
DI Xiuting;  WEI Shixiong;  ZHANG Shaowei;  TIAN Yu;  ZHANG Yuhai; ZHANG Anling
(1.Department of Intensive Medicine,Liaocheng Hospital of Traditional Chinese Medicine,Liaocheng 252000,Shandong,China; 2.Department of Cardiovascular Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853,China; 3. Department of Cardiovascular Surgery,The 989th Hospital of the Joint Logistics Support Unit,Luoyang 471000,Henan,China; 4.Surgical Clinical Department,General Hospital of Chinese People’s Liberation Army,Beijing 100853,China; 5.Baotou Clinical Medical College,Inner Mongolia Medical University,Baotou 014000,Inner Mongolia,China; 6. Jilin FAW General Hospital,Changchun 100853,Jilin,China) E-mailwei_shixiong@163.com
关键词:
感染性心内膜炎; 红细胞分布宽度; 术后死亡
Keywords:
Infective endocarditis; Red cell distribution width; Postoperative mortality
DOI:
10.16806/j.cnki.issn.1004-3934.2020.07.024
摘要:
目的 感染性心内膜炎（IE）是一种常见且伴有较高死亡率的疾病，近来红细胞分布宽度（RDW）这一指标在对心血管疾病预测方面的作用已引起了学者们的广泛关注，本次研究旨在探究RDW值对IE患者术后死亡的预测价值。方法 收集2016年1月—2019年1月于解放军总医院心血管外科确诊为IE的患者临床资料，分析患者入院时的RDW值与其余血清学检测、临床特征和超声心动图等指标对其发生院内死亡的预测价值。结果 本次研究共纳入158例IE患者，年龄（47.0±16.3）岁，其中男性61.4%，共28例患者（17.8%）于术后死亡，其中25例（89.3%）死于感染性休克，3例死于突发脑梗死。ROC曲线分析结果表明预测术后院内死亡的最佳RDW截断值为15.45%（ROC曲线下面积：0.913，P＜0.001），其在本次研究中的灵敏度与特异度分别为89.3%与55.6%。二元回归分析表明，老龄、多瓣膜累及、瓣膜赘生物形成、肺动脉高压和高RDW值是术后院内死亡的预测因子，而多元回归分析显示高RDW值是IE患者术后死亡率的独立预测因子。（β：3.704，95% CI 2.729～604.692，P＜0.05）。结论 IE患者院内死亡率较高，本次研究表明入院时较高的RDW值是这类患者术后死亡的独立预测因素。 【
Abstract:
Objective Infective endocarditis(IE) is a common disease with high mortality rate. Recently, red cell distribution width (RDW) has drawn special attention for predicting cardiovascular disease. This study is to explore the relationship between RDW value and perioperative death of IE patients. Methods Clinical records of patients with definite IE from Chinese People’s Liberation Army General Hospital(department of cardiovascular surgery) were collected and analyzed. Clinical, echocardiographic and biochemical variables were evaluated along with RDW. Results A total of 158 consecutive IE patients [mean age (47.0±16.3) years, male 61.4%] were enrolled in this study. According to receiver operating characteristic curve analysis, the optimal RDW cut-off value for predicting mortality was 15.45% (area under the curve 0.913, P＜0.001). 28 patients (17.8%) died postoperatively, of these 89.3% had RDW value＞15.45%. Binary regression analysis showed that aging, multiple valvular involved, valvular vegetations formation, pulmonary hypertension and high RDW are strong predictors of postoperative death. Multiple regression analysis revealed that high RDW value was independent predictors of postoperative mortality in patients with IE(β 3.704, 95% CI 0.775 ～0.967, P＜0.05). Conclusion IE has a high in-hospital mortality rate and that increased RDW is an independent predictor of postoperative death in these patients. 【

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更新日期/Last Update: 2020-10-10