[1]杨张娅 温恩懿.内皮素-1在血管平滑肌细胞增殖作用中的研究进展[J].心血管病学进展,2020,(5):524-526.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.020]
　YANG Zhangya,WEN Enyi.Endothelin-1 in Proliferation of Vascular Smooth Muscle Cells[J].Advances in Cardiovascular Diseases,2020,(5):524-526.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.020]
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内皮素-1在血管平滑肌细胞增殖作用中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年5期
页码:
524-526
栏目:
出版日期:
2020-05-25

文章信息/Info

Title:
Endothelin-1 in Proliferation of Vascular Smooth Muscle Cells
作者:
杨张娅 温恩懿
(陆军军医大学第二附属医院儿科,重庆 400038)
Author(s):
YANG Zhangya; WEN Enyi
(Department of Pediatrics,The Second Affiliated Hospital of Army Military Medical University,Chongqing 400038,China)
关键词:
内皮素-1; 平滑肌细胞; 细胞增殖
Keywords:
Endothelin-1; Smooth muscle cell; Cell proliferation
DOI:
10.16806/j.cnki.issn.1004-3934.2020.05.020
摘要:
血管重构是血管壁功能和结构异常改变的过程，涉及血管内皮细胞、血管平滑肌细胞和细胞外基质的病理改变。血管平滑肌细胞增殖在血管重构中起关键性的作用。内皮素-1是一种活性多肽，参与调控血管平滑肌细胞收缩、增殖、迁移和基因表达等多项细胞功能。内皮素-1在平滑肌细胞增殖的作用机制可能是防止血管重构的关键靶点。
Abstract:
Vascular remodeling is a process of abnormal changes in function and structure of blood vessel walls,involving the pathological changes in vascular endothelial cells, vascular smooth muscle cells and extracellular matrices.Vascular smooth muscle cell proliferation plays a key role in vascular remodeling. Endothelin-1 is an active polypeptide involved in the regulation of vascular smooth muscle cell contraction, proliferation, migration, gene expression and other cellular functions.The mechanism of action of ET-1 in smooth muscle cell proliferation may be a key target for preventing vascular remodeling

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更新日期/Last Update: 2020-08-12