[1]王双 冯景辉 吴丽馨 付俊博 吴秀萍.脑啡肽酶抑制剂对心力衰竭患者认知功能的研究进展[J].心血管病学进展,2019,(9):1253-1256.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.017]
 WANG ShuangFENG JinghuiWU LixinFU JunboWU Xiuping.Enkephalase Lnhibitors on Cognitive Function in Patients with Heart Failure[J].Advances in Cardiovascular Diseases,2019,(9):1253-1256.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.017]
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脑啡肽酶抑制剂对心力衰竭患者认知功能的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年9期
页码:
1253-1256
栏目:
综述
出版日期:
2019-12-25

文章信息/Info

Title:
Enkephalase Lnhibitors on Cognitive Function in Patients with Heart Failure
作者:
王双 冯景辉 吴丽馨 付俊博 吴秀萍
(哈尔滨医科大学附属第一医院老年病科,黑龙江 哈尔滨 150001)
Author(s):
WANG ShuangFENG JinghuiWU LixinFU JunboWU Xiuping
(Department of GeriatricsThe First Affiliated Hospital Of HRB Medical UniversityHarbin 150001HeilongjiangChina)
关键词:
心力衰竭脑啡肽酶脑啡肽酶抑制剂认知功能沙库巴曲/缬沙坦阿尔茨海默病血脑屏障β-淀粉样蛋白
Keywords:
Heart failureNeprilysineprilysin inhibitorCognitive functionSacubitril/valsartanAlzheimers diseaseBlood brain barrier-amyloid
DOI:
10.16806/j.cnki.issn.1004-3934.2019.09.017
摘要:
沙库巴曲/缬沙坦在治疗左心室射血分数降低的慢性心力衰竭中,它是通过抑制脑啡肽酶来提高利钠肽的浓度从而起到治疗作用。但同时它还增加了血管活性肽、神经肽和β-淀粉样蛋白的水平。理论上讲,增加β-淀粉样蛋白可以增加服用本药患者认知功能障碍的风险,现就长期使用脑啡肽酶抑制对心力衰竭患者认知功能影响的各种观点进行综述。
Abstract:
Sacubitril/valsartan is effective in treating chronic heart failure with reduced left ventricular ejection fraction by inhibiting neprilysin and increasing the natriuretic peptides. However, it also increases levels of vasoactive peptides, neuropeptides, and β-amyloid(Aβ). In theory, elvated Aβ could increase the risk of cognitive impairment in patients taking the drug. This article will review the effects of long-term neprilysin inhibition on cognitive function in patients with heart failure

参考文献/References:

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更新日期/Last Update: 2020-02-06