[1]柴囡楠,张昊,李玲旭,等.宫内缺氧对胎儿、新生儿及成年子代心脏功能的影响及相关研究进展[J].心血管病学进展,2016,(4):401-404.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.019]
 CHAI Nannan,ZHANG Hao,LI Lingxu,et al.Research Progress of Effect of Intrauterine Hypoxia on Cardiac Functions of Fetus, Newborn and Adult Offspring[J].Advances in Cardiovascular Diseases,2016,(4):401-404.[doi:10.16806/j.cnki.issn.1004-3934.2016.04.019]
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宫内缺氧对胎儿、新生儿及成年子代心脏功能的影响及相关研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年4期
页码:
401-404
栏目:
综述
出版日期:
2016-08-15

文章信息/Info

Title:
Research Progress of Effect of Intrauterine Hypoxia on Cardiac Functions of Fetus, Newborn and Adult Offspring
作者:
柴囡楠12张昊1李玲旭1王俊莹1综述赵雅君1审校
1.哈尔滨医科大学病理生理教研室,黑龙江 哈尔滨 150086; 2.赤峰学院医学院,内蒙古 赤峰 024000
Author(s):
CHAI Nannan12ZHANG Hao1LI Lingxu1WANG Junying1ZHAO Yajun1
1.Department of Pathophysiology,Harbin Medical University,Harbin 150086,Heilongjiang,China; 2.Chifeng University,Chifeng 024000,Neimenggu,China
关键词:
宫内缺氧 心脏功能 胎儿编程 胎儿、新生儿与成年子代大鼠
Keywords:
Intrauterine hypoxia Cardiac function Fetal programming Fetusnewborn and adult offspring rat
分类号:
R541.6+1
DOI:
10.16806/j.cnki.issn.1004-3934.2016.04.019
文献标志码:
A
摘要:
宫内缺氧是胚胎发育中的常见综合征,多见于产前期病理生理高危妊娠,或由于血管病变使子宫血流减少,使宫内胎儿供氧减少,引起胎儿生长迟缓,严重的可引起胎儿死亡。妊娠期间慢性宫内缺氧可抑制胎儿心脏功能,改变心脏基因表达,增加心肌程序性细胞死亡,还可导致心肌细胞过早退出细胞周期和心肌肥厚,这些改变不仅在围生期表现明显,而且可能通过生理和代谢的程序化控制,引起成年子代心脏结构和功能的改变,造成成年心脏对缺血-再灌注损伤的易感性增加。现就宫内缺氧对胎儿、新生儿及成年子代心脏功能的影响及相关研究进展进行综述。
Abstract:
Intrauterine hypoxia is a common syndrome in embryonic development, especially in prenatal period as a result of pathophysiologic high-risk pregnancy or uterine blood flow decrease due to vascular disease, consequently reducing oxygen supply to the fetus and retarding fetal growth or even causing fetus death. Chronic intrauterine hypoxia during pregnancy will inhibit fetal cardiac function, change cardiac gene expressions, increase apoptosis of myocardial cells, and also contribute to premature withdraw of myocardial cells from cell cycle and myocardial hypertrophy. These changes manifest clearly in the perinatal period, and may work via physiological and metabolic program control to change adult cardiac structures and functions as well as increase adult heart susceptibility to ischemia or reperfusion injury. Therefore, it is necessary to review both the effects of intrauterine hypoxia on cardiac functions of fetus, newborn and adult offspring with relevant research.

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金资助项目(8170178) 作者简介:柴囡楠(1980—),讲师,在读硕士,主要从事心血管疾病研究。Email:cnncnn@163.com 通信作者:赵雅君,研究员、博士生导师,博士,主要从事心血管疾病研究。Email:zhaoyajun1964@163.com
更新日期/Last Update: 2016-07-25