[1]宋菲,综述,俞梦越,等.干细胞来源的外泌体:心肌梗死治疗新启示[J].心血管病学进展,2016,(2):125-129.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.007]
 SONG Fei,YU Mengyue.Exosomes Derived from Stem Cells: Novel Approach in Treatment of Myocardial Infarction[J].Advances in Cardiovascular Diseases,2016,(2):125-129.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.007]
点击复制

干细胞来源的外泌体:心肌梗死治疗新启示()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年2期
页码:
125-129
栏目:
综述
出版日期:
2016-04-20

文章信息/Info

Title:
Exosomes Derived from Stem Cells: Novel Approach in Treatment of Myocardial Infarction
作者:
宋菲1综述俞梦越2审校
1.北京协和医学院 中国医学科学院 阜外医院,北京 100044; 2.中国医学科学院 阜外医院,北京 100044
Author(s):
SONG Fei1 YU Mengyue2
1.Peking Union Medical College, Chinese Academy of Medical Sciences & Fu Wai Hospital, Beijing 100044, China; 2.Chinese Academy of Medical Sciences & Fu Wai Hospital, Beijing 100044,China
关键词:
外泌体 干细胞 心肌梗死
Keywords:
Exsomes Stem cell Myocardial infarction
分类号:
R542.2
DOI:
10.16806/j.cnki.issn.1004-3934.2016.02.007
文献标志码:
A
摘要:
外泌体是在细胞间交流中起重要作用的外分泌纳米级磷脂双层囊泡,可由多种细胞分泌,在细胞间有效转运蛋白质、RNA等生命活性物质。值得注意的是,近期研究发现干细胞分泌的外泌体可以减少心肌细胞凋亡,促进心肌细胞、血管内皮细胞增殖分化,因而为心肌梗死提出了一种创新的生物分子治疗方式,现主要论述干细胞来源外泌体在治疗心肌梗死中的最新研究进展和对未来治疗应用的展望。
Abstract:
Exosomes are nanosized secreted vesicles with phospholipid bilayers, which play important roles in cell-to-cell communication.Exosomes can be released by various cells and transport protein and RNA effectively between cells.Recent studies discovered that exosomes derived from stem cells exerted anti-apoptosis,cardiac regeneration and neo-vascularization effect, which are considered as novel molecular mechanisms of therapeutic potential of myocardial infarction.This review mainly summarizes the recent advances in research and discussed exosomes as a novel approach in the treatment of myocardial infarction in the future.

参考文献/References:

[1] Kanashiro-Takeuchi RM,Schulman IH,Hare JM.Pharmacologic and genetic strategies to enhance cell therapy for cardiac regeneration[J].J Mol Cell Cardiol,2011,51(4):619-625.
[2] Iglesias-Garcia O,Pelacho B,Prosper F.Induced pluripotent stem cells as a new strategy for cardiac regeneration and disease modeling[J].J Mol Cell Cardiol,2013,62:43-50.
[3] Makridakis M,Roubelakis MG,Vlahou A.Stem cells: insights into the secretome[J].Biochim Biophys Acta,2013,1834(11):2380-2384.
[4] Ailawadi S,Wang X,Gu H,et al.Pathologic function and therapeutic potential of exosomes in cardiovascular disease[J].Biochim Biophys Acta,2015,1852(1):1-11.
[5] Huang L,Ma W,Ma Y,et al.Exosomes in mesenchymal stem cells, a new therapeutic strategy for cardiovascular diseases?[J].Int J Biol Sci,2015,11(2):238-245.
[6] Kurpinski K,Lam H,Chu J,et al.Transforming growth factor-beta and notch signaling mediate stem cell differentiation into smooth muscle cells[J].Stem Cells,2010,28(4):734-742.
[7] Dufourcq P,Descamps B,Tojais NF,et al.Secreted frizzled-related protein-1 enhances mesenchymal stem cell function in angiogenesis and contributes to neovessel maturation[J].Stem Cells,2008,26(11):2991-3001.
[8] Tang YL,Zhao Q,Qin X,et al.Paracrine action enhances the effects of autologous mesenchymal stem cell transplantation on vascular regeneration in rat model of myocardial infarction[J].Ann Thorac Surg,2005,80(1):229-236, 236-237.
[9] Arslan F,Lai RC,Smeets MB,et al.Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury[J].Stem Cell Res,2013,10(3):301-312.
[10] Feng Y,Huang W,Wani M,et al.Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22[J].PLoS One,2014,9(2):e88685.
[11] Yu B,Gong M,Wang Y,et al.Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles[J].PLoS One,2013,8(8):e73304.
[12] Kang K,Ma R,Cai W,et al.Exosomes secreted from CXCR4 overexpressing mesenchymal stem cells promote cardioprotection via Akt signaling pathway following myocardial infarction[J].Stem Cells Int,2015,2015:659890.
[13] Salomon C,Ryan J,Sobrevia L,et al.Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis[J].PLoS One,2013,8(7):e68451.
[14] Lopatina T,Bruno S,Tetta C,et al.Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential[J].Cell Commun Signal,2014,12:26.
[15] Zhao Y,Sun X,Cao W,et al.Exosomes derived from human umbilical cord mesenchymal stem cells relieve acute myocardial ischemic injury[J].Stem Cells Int,2015,2015:761643.
[16] Bian S,Zhang L,Duan L,et al.Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model[J].J Mol Med(Berl),2014,92(4):387-397.
[17] Sanada S,Komuro I,Kitakaze M.Pathophysiology of myocardial reperfusion injury:preconditioning, postconditioning, and translational aspects of protective measures[J].Am J Physiol Heart Circ Physiol,2011,301(5):H1723-H1741.
[18] Balmer GM,Riley PR.Harnessing the potential of adult cardiac stem cells: lessons from haematopoiesis, the embryo and the niche[J].J Cardiovasc Transl Res,2012,5(5):631-640.
[19] Sahoo S,Klychko E,Thorne T,et al.Exosomes from human CD34(+)stem cells mediate their proangiogenic paracrine activity[J].Circ Res,2011,109(7):724-728.
[20] Mackie AR,Klyachko E,Thorne T,et al.Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction[J].Circ Res,2012,111(3):312-321.
[21] Vrijsen KR,Sluijter JP,Schuchardt MW,et al.Cardiomyocyte progenitor cell-derived exosomes stimulate migration of endothelial cells[J].J Cell Mol Med,2010,14(5):1064-1070.
[22] Barile L,Lionetti V,Cervio E,et al.Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction[J].Cardiovasc Res,2014,103(4):530-541.
[23] Chen L,Wang Y,Pan Y,et al.Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury[J].Biochem Biophys Res Commun,2013,431(3):566-571.
[24] Gray WD,French KM,Ghosh-Choudhary S,et al.Identification of therapeutic covariant microRNA clusters in hypoxia-treated cardiac progenitor cell exosomes using systems biology[J].Circ Res,2015,116(2):255-263.
[25] Smith RR,Barile L,Cho HC,et al.Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens[J].Circulation,2007,115(7):896-908.
[26] Cheng K,Malliaras K,Smith RR,et al.Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair[J].JACC Heart Fail,2014,2(1):49-61.
[27] Khan M,Nickoloff E,Abramova T,et al.Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction[J].Circ Res,2015,117(1):52-64.
[28] Wang Y,Zhang L,Li Y,et al.Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium[J].Int J Cardiol,2015,192:61-69.
[29] Emanueli C,Shearn AI,Angelini GD,et al.Exosomes and exosomal miRNAs in cardiovascular protection and repair[J].Vascul Pharmacol,2015,71:24-30.

相似文献/References:

[1]姚雯,毛露,孙硕,等.心源性外泌体作为冠心病标志物和新靶点展望[J].心血管病学进展,2019,(6):844.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.002]
 YAO Wen,MAO Lu,SUN Shuo,et al.Exogenous Exosome as A New Marker and Target of Coronary Heart Disease[J].Advances in Cardiovascular Diseases,2019,(2):844.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.002]
[2]张维 张恒 康品方.外泌体在心血管疾病中的研究进展[J].心血管病学进展,2019,(5):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
 Zhang WeiKang Pinfang.Exosome in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(2):818.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.038]
[3]张伟 木胡牙提.外泌体源性miRNAs在心血管疾病中的研究进展[J].心血管病学进展,2020,(2):111.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.002]
 Zhang Wei,Muhuyati.Exogenous miRNAs in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2020,(2):111.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.002]
[4]李一凡 张智伟.巨噬细胞相关的外泌体在心血管疾病中的作用研究进展[J].心血管病学进展,2020,(8):839.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.014]
 LI Yifan,ZHANG Zhiwei.Role of Macrophage-Related Exosomes in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2020,(2):839.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.014]
[5]叶莎 杨翠玲 郑媛媛.骨髓间充质干细胞来源外泌体通过PI3K/Akt途径减轻H2O2诱导心肌细胞损伤[J].心血管病学进展,2022,(3):269.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
 YE Sha,YANG Cuiling,ZHENG Yuanyuan.Bone Marrow Mesenchymal Stem Cells Derived Exosomes Attenuate H 2O2 Induced Cardiomyocyte Injury Via PI3K/Akt Pathway[J].Advances in Cardiovascular Diseases,2022,(2):269.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
[6]肖轶 余国龙.不同干细胞来源的外泌体在缺血性心脏病中的促血管新生作用[J].心血管病学进展,2022,(4):293.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.002]
 XIAO Yi,YU Guolong?/html>.Application of Exosomes Derived from Various Stem Cells?n Ischemic Heart Disease[J].Advances in Cardiovascular Diseases,2022,(2):293.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.002]
[7]俞佳丽 景雨 张剑 陈楚 陆齐 顾周山 陈子微 周大胜 景宏美 潘丽华.间充质干细胞来源的外泌体在心肌梗死治疗中的研究进展[J].心血管病学进展,2022,(4):341.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.013]
 YU JialiJING YuZHANG JianCHEN ChuLU QiGU ZhoushanCHEN ZiweiZHOU DashenJING HongmeiPAN Lihua.Exosomes Derived from Mesenchymal Stem Cells?n the Treatment of Myocardial Infarction[J].Advances in Cardiovascular Diseases,2022,(2):341.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.013]
[8]杨珂欣 李星辉 肖晨朦 姚晓涛 林萌 蔡佳.间充质干细胞来源外泌体改善心肌纤维化的研究进展[J].心血管病学进展,2022,(12):1123.[doi:10.16806/j.cnki.issn.1004-3934.20.10.015]
 YANG Kexin LI Xinghui XIAO ChenmengYAO XiaotaoLIN MengCAI Jia.Improving Myocardial Fibrosis by Exosome Derived from Mesenchymal Stem Cell[J].Advances in Cardiovascular Diseases,2022,(2):1123.[doi:10.16806/j.cnki.issn.1004-3934.20.10.015]
[9]陈鹏莉 宋紫微 张曼玉 李丽丽.干细胞来源外泌体miRNA介导心脏修复的研究进展[J].心血管病学进展,2023,(7):636.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.014]
 CHEN Pengli,SONG Ziwei,ZHANG Manyu,et al.Exosomal miRNA Derived from Stem Cells in Mediating Cardiac Repair[J].Advances in Cardiovascular Diseases,2023,(2):636.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.014]
[10]杨安妮 厉腊梅 王绿娅 蔡高军.外泌体与脂质代谢研究进展[J].心血管病学进展,2024,(8):753.[doi:10.16806/j.cnki.issn.1004-3934.2024.08.017]
 YANG Anni,LI Lamei,WANG Lyuya,et al.Research Progress on Exosomes and Lipid Metabolism[J].Advances in Cardiovascular Diseases,2024,(2):753.[doi:10.16806/j.cnki.issn.1004-3934.2024.08.017]

备注/Memo

备注/Memo:
作者简介:宋菲(1990—),在读硕士,主要从事冠心病研究。Email: songfeifeisong@163.com 通信作者:俞梦越(1973—),主任医师,硕士生导师,博士,主要从事冠心病介入研究。Email: yumy73@163.com
更新日期/Last Update: 2016-03-25