[1]胥雪莲,何川.前蛋白转化酶枯草溶菌素9与动脉粥样硬化[J].心血管病学进展,2016,(1):50-53.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.013]
 XU Xuelian,HE Chuan.Proprotein Convertase Subtilisin/Kexin Type 9 and Atherosclerosis[J].Advances in Cardiovascular Diseases,2016,(1):50-53.[doi:10.16806/j.cnki.issn.1004-3934.2016.01.013]
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前蛋白转化酶枯草溶菌素9与动脉粥样硬化()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年1期
页码:
50-53
栏目:
综述
出版日期:
2016-02-20

文章信息/Info

Title:
Proprotein Convertase Subtilisin/Kexin Type 9 and Atherosclerosis
作者:
胥雪莲1何川2
1.重庆医科大学附属大学城医院心血管内科,重庆 401331;
2.成都大学附属医院心血管内科,四川 成都 610081
Author(s):
XU Xuelian1 HE Chuan2
1.Department of Cardiology,University-Town Hospital of Chongqing Medical University,Chongqing 401331,China;
2. Department of Cardiology,Affiliated Hospital/Clinical Medical College of Chengdu University,Chengdu 610081,Sichuan,China
关键词:
前蛋白转化酶枯草溶菌素9 动脉粥样硬化 低密度脂蛋白受体
Keywords:
Proprotein convertase subtilisin/kexin type 9 Atherosclerosis Low-density lipoprotein receptor
分类号:
R543
DOI:
10.16806/j.cnki.issn.1004-3934.2016.01.013
文献标志码:
A
摘要:
动脉粥样硬化是严重危害人类健康的重大疾病。新近的研究表明,前蛋白转化酶枯草溶菌素9作为降解低密度脂蛋白受体的重要分子,影响前蛋白转化酶枯草溶菌素9-低密度脂蛋白受体途径导致低密度脂蛋白代谢异常,与动脉粥样硬化形成的关系密切。现就前蛋白转化酶枯草溶菌素9影响动脉粥样硬化研究进展做一综述。
Abstract:
Atherosclerosis is a serious disease that is harmful to human health. Proprotein convertase subtilisin/kexin type 9(PCSK9), a newly recognized protein, which plays a key role in cholesterol homeostasis by enhancing the degradation of hepatic low-density lipoprotein receptor and causing marked increases in low-density lipoprotein cholesterol concentration and atherosclerosis. This review provides important links between PCSK9, low-density lipoprotein receptor and the mechanisms of atherosclerosis.

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备注/Memo

备注/Memo:
基金项目:重庆市科委自然科学基金计划资助项目(cstc2012jjA10045); 重庆市渝中区科委科技计划项目(20130129)
作者简介:胥雪莲(1978—),主治医师,博士,主要从事动脉粥样硬化研究。Email:2480074@qq.com
通信作者:何川,副主任医师,硕士,主要从事电生理研究。Email:1492043949@qq.com
更新日期/Last Update: 2016-02-20