[1]章晶晶 黄鹤.自噬在冠状动脉粥样硬化性心脏病中的研究进展[J].心血管病学进展,2024,(4):312.[doi:10.16806/j.cnki.issn.1004-3934.2024.04.006]
 ZHANG JingjingHUANG He.Autophagy in Coronary Heart Disease[J].Advances in Cardiovascular Diseases,2024,(4):312.[doi:10.16806/j.cnki.issn.1004-3934.2024.04.006]
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自噬在冠状动脉粥样硬化性心脏病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2024年4期
页码:
312
栏目:
综述
出版日期:
2024-04-25

文章信息/Info

Title:
Autophagy in Coronary Heart Disease
作者:
章晶晶 黄鹤
(武汉大学人民医院心内科 心血管病湖北省重点实验室 武汉大学心血管病研究所,湖北 武汉 430060)
Author(s):
ZHANG JingjingHUANG He
(Department of Cardiology,Renmin Hospital of Wuhan University,Hubei Key Laboratory of Cardiology,Cardiovascular Research Institute of Wuhan University,Wuhan 430060,Hubei,China)
关键词:
冠状动脉粥样硬化性心脏病细胞自噬正向调节作用负向调节作用相关治疗
Keywords:
Coronary atherosclerotic heart diseaseAutophagyPositive regulatory effectNegative regulatory effectRelated treatment
DOI:
10.16806/j.cnki.issn.1004-3934.2024.04.006
摘要:
冠状动脉粥样硬化性心脏病(CHD)是全球最常见的死亡原因。自噬或巨自噬是一种生存机制,它是指将细胞质成分吞噬到双膜自噬体中,随后将其传递给溶酶体降解,从而通过重新利用消化的细胞成分使细胞存活的过程。细胞自噬是适应性反应,对细胞生长、存活和细胞稳态至关重要。近期发现,自噬与CHD的发生发展密切相关。正常的自噬对心肌细胞有保护作用,自噬不足或自噬过度会加重CHD的进展。现对自噬在CHD中的研究进展做一综述。
Abstract:
coronary atherosclerotic heart disease is the most common cause of death worldwide. Autophagy,or macroautophagy,is a survival mechanism that refers to the process of phagocytosis of cytoplasmic components into the double-membrane autophagosome,which is subsequently passed on to lysosome for degradation,thereby keeping cells alive by recycling the digested cellular components. Autophagy is an adaptive response that is essential for cell growth,survival and homeostasis. Recently,autophagy has been found to be closely related to the occurrence and development of coronary heart disease. Normal autophagy has a protective effect on cardiomyocytes,and insufficient or excessive autophagy can aggravate the progression of coronary heart disease. The article reviews the research progress of autophagy in coronary heart disease

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(82070330)
更新日期/Last Update: 2024-05-31