[1]马佳 陈肯 张宇清.儿童及青少年单纯收缩期高血压发病机制研究进展[J].心血管病学进展,2020,(4):392-394.[doi:10.16806/j.cnki.issn.1004-3934.2020.04.016]
 MA Jia,CHEN Ken,ZHANG Yuqing.The Pathogenesis of Isolated Systolic Hypertension in Children and Adolescents[J].Advances in Cardiovascular Diseases,2020,(4):392-394.[doi:10.16806/j.cnki.issn.1004-3934.2020.04.016]
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儿童及青少年单纯收缩期高血压发病机制研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年4期
页码:
392-394
栏目:
综述
出版日期:
2020-04-25

文章信息/Info

Title:
The Pathogenesis of Isolated Systolic Hypertension in Children and Adolescents
作者:
马佳 陈肯 张宇清
(北京协和医学院 中国医学科学院阜外医院国家心血管病中心 国家心血管疾病临床医学研究中心 国家卫生健康委员会心血管药物临床研究重点实验室 心血管疾病国家重点实验室 中国牛津国际医学研究中心,北京 100037)
Author(s):
MA Jia CHEN Ken ZHANG Yuqing
(National Clinical Research Center of Cardiovascular Diseases,State Key Laboratory of Cardiovascular,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037, China)
关键词:
儿童青少年单纯收缩期高血压交感神经
Keywords:
Children Adolescent Isolated systolic hypertension Sympathetic system
DOI:
10.16806/j.cnki.issn.1004-3934.2020.04.016
摘要:
单纯收缩期高血压(ISH)是老年人高血压最为常见的类型,其对心血管事件的发生有重要影响。值得注意的是,ISH在儿童及青少年中也很常见。与儿童及青少年ISH发病机制不同,大动脉僵硬度增加是老年人ISH的主要发病机制。多项研究表明,儿童及青少年ISH的主要发病机制为交感神经活动亢进,可表现为:高动力状态、肾素-血管紧张素-醛固酮系统激活等。现从儿童及青少年ISH发病机制的研究进展做一综述。
Abstract:
It has been demonstrated that the isolated systolic hypertension(ISH) is the most common type of hypertension in the elderly,which has a significant relationship with the occurrence of cardiovascular events ,and its main mechanism is the increased stiffness in large arteries. Of note,the adolescents can suffer from ISH as well,but the mechanisms responsible are very different.Several previous studies have shown that the increased activity of sympathetic system,such as hyperkinetic status and the activation of renin-angiotensin-aldosterone system(R AAS),is the major determinant of ISH in adolescents.This review is aimed to elucidate the progress in mechanism research of ISH occurring to adolescents.

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备注/Memo

备注/Memo:
通讯作者:张宇清,E-mail:yqzhang99@yahoo.com
收稿时间:2019-10-23
更新日期/Last Update: 2020-07-28