[1]李莹洁 吴镜.老年肌少症与冠状动脉粥样硬化性心脏病相关性的研究进展[J].心血管病学进展,2025,(12):1081.[doi:10.16806/j.cnki.issn.1004-3934.2025.12.006]
 LI Yingjie,WU Jing.Relationship Between Senile Myopenia and Coronary Atherosclerotic Heart Disease[J].Advances in Cardiovascular Diseases,2025,(12):1081.[doi:10.16806/j.cnki.issn.1004-3934.2025.12.006]
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老年肌少症与冠状动脉粥样硬化性心脏病相关性的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年12期
页码:
1081
栏目:
综述
出版日期:
2025-12-25

文章信息/Info

Title:
Relationship Between Senile Myopenia and Coronary Atherosclerotic Heart Disease
作者:
李莹洁 吴镜
(西南交通大学附属医院 成都市第三人民医院老年科,四川 成都 610031)
Author(s):
LI YingjieWU Jing
(Department of Geriatrics,The Third Peoples Hospital of Chengdu,The Affiliated Hospital of Southwest Jiaotong University,Chengdu 610031,Sichuan,China)
关键词:
冠状动脉粥样硬化性心脏病肌少症心血管疾病
Keywords:
Coronary atherosclerotic heart disease Sarcopenia Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2025.12.006
摘要:
肌肉减少症(肌少症)是一种起病隐匿的全身性骨骼肌疾病,与多种心血管疾病密切相关,其中,冠状动脉粥样硬化性心脏病(CHD)与肌少症双向关联,而非简单共病。增龄、营养不良、体力活动减少、胰岛素抵抗等,均参与了二者的发生。CHD患者存在慢性炎症、氧化应激、营养不良和体力活动减少,可导致肌肉流失、促进肌少症的发生发展。肌少症常引起肌少性肥胖、影响肌动蛋白水平与功能,促进动脉粥样硬化,从而增加CHD患病风险;肌少症还会影响老年CHD患者心功能及预后,增加其跌倒、失能、再住院和死亡风险。本文对肌少症与CHD的共同危险因素、相互影响、发病机制以及对老年CHD患者肌少症的筛查评估和干预措施进行综述,以期为老年CHD合并肌少症患者的临床诊疗提供科学依据。
Abstract:
Sarcopenia is a systemic skeletal muscle disease with insidious onset. It is closely related to various cardiovascular diseases, among which coronary atherosclerotic heart disease(CHD) is bidirectionally associated with sarcopenia rather than simply comorbid. Aging, malnutrition, reduced physical activity, and insulin resistance are all involved in the occurrence of both. Patients with CHD suffer from chronic inflammation, oxidative stress, malnutrition, and reduced physical activity, which can lead to muscle loss and promote the occurrence and development of sarcopenia. Myopenia often causes myopenic obesity, affects the level and function of actin, promotes atherosclerosis, thus increasing the risk of CHD, and affects the cardiac function and prognosis of elderly patients with CHD, leading to weakness and cachexia, increasing the risk of falls, disability, re hospitalization and death. This article reviews the common risk factors, mutual influence, pathogenesis, screening, evaluation, and intervention measures for sarcopenia in elderly patients with CHD, aiming to provide scientific basis for the clinical diagnosis and treatment of elderly patients with CHD complicated with sarcopenia.

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更新日期/Last Update: 2026-04-14