[1]何建 岳田 熊诗强 杨佳丽 侯君.线粒体自噬在慢性心力衰竭中的研究进展[J].心血管病学进展,2025,(9):838.[doi:10.16806/j.cnki.issn.1004-3934.2025.09.016]
 HE Jian,YUE Tian,XIONG Shiqiang,et al.Mitochondrial Autophagy in Chronic Heart Failure[J].Advances in Cardiovascular Diseases,2025,(9):838.[doi:10.16806/j.cnki.issn.1004-3934.2025.09.016]
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线粒体自噬在慢性心力衰竭中的研究进展()

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年9期
页码:
838
栏目:
综述
出版日期:
2025-09-25

文章信息/Info

Title:
Mitochondrial Autophagy in Chronic Heart Failure
作者:
何建2 岳田1 熊诗强1 杨佳丽2 侯君1
(1.成都市第三人民医院心血管内科,四川 成都 610031;2.西南交通大学生命科学与工程学院,四川 成都 610031)
Author(s):
HE Jian12YUE Tian1XIONG Shiqiang1YANG Jiali2HOU Jun1
Department of Cardiology,The Third Peoples Hospital of Chengdu,Chengdu 610031,Sichuan,China; 2. School of Life Science And Engineering,Southwest Jiaotong University,Chengdu 610031,Sichuan,China)
关键词:
慢性心力衰竭线粒体自噬心肌细胞氧化应激细胞凋亡心脏保护
Keywords:
Chronic heart failureMitochondrial autophagyCardiomyocytesOxidative stressApoptosisCardioprotection
DOI:
10.16806/j.cnki.issn.1004-3934.2025.09.016
摘要:
慢性心力衰竭是一种严重的心血管疾病,其病理过程复杂多样,线粒体自噬在其中发挥着关键作用。线粒体自噬是通过选择性清除受损或功能失调的线粒体,以维持细胞健康和功能的一种特殊自噬过程。在心力衰竭中,线粒体自噬通过调节线粒体的质量控制,维持心肌细胞的代谢平衡和功能稳定,减轻氧化应激和细胞凋亡,同时线粒体自噬参与线粒体网络的重塑,支持心肌细胞在压力环境下的适应性反应。药物干预和基因调控对线粒体自噬影响的相关研究揭示了其在心血管疾病治疗中的潜力。现综述线粒体自噬的基本概念、机制以及其在慢性心力衰竭中的作用和调控,为未来的研究和临床治疗提供理论依据和新思路。
Abstract:
Chronic heart failure is a serious cardiovascular disease with a complex and diverse pathological process in which mitochondrial autophagy plays a key role. Mitochondrial autophagy is a specialised autophagic process that maintains cellular health and function by selectively removing damaged or dysfunctional mitochondria. In heart failure,mitochondrial autophagy maintains metabolic homeostasis and functional stability of cardiomyocytes by regulating mitochondrial quality control,attenuating oxidative stress and apoptosis,while mitochondrial autophagy is involved in remodelling the mitochondrial network to support the adaptive response of cardiomyocytes in stressful environments. Studies related to the effects of pharmacological interventions and gene regulation on mitochondrial autophagy reveal its potential in the treatment of cardiovascular diseases. This article reviews the basic concepts and mechanisms of mitochondrial autophagy,as well as its role and regulation in chronic heart failure,providing a theoretical basis and new ideas for future research and clinical treatment

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更新日期/Last Update: 2025-12-18