[1]张可意 杨萍.RNA结合基序蛋白介导的可变剪接在心力衰竭中的作用机制进展[J].心血管病学进展,2025,(4):327.[doi:10.16806/j.cnki.issn.1004-3934.2025.04.010]
　ZHANG Keyi,YANG Ping.Mechanism Research Progress of RNA Binding Motif Protein Mediated Alternative Splicing in Heart Failure[J].Advances in Cardiovascular Diseases,2025,(4):327.[doi:10.16806/j.cnki.issn.1004-3934.2025.04.010]
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RNA结合基序蛋白介导的可变剪接在心力衰竭中的作用机制进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年4期
页码:
327
栏目:
综述
出版日期:
2025-04-25

文章信息/Info

Title:
Mechanism Research Progress of RNA Binding Motif Protein Mediated Alternative Splicing in Heart Failure
作者:
张可意 杨萍
(昆明医科大学第一附属医院心脏内一科,云南 昆明 650000)
Author(s):
ZHANG Keyi; YANG Ping
(Department of Cardiology,The First Affiliated Hospital of Kunming Medical University,Kunming 650000,Yunnan,China)
关键词:
可变剪接; RNA结合基序蛋白20; RNA结合基序蛋白24; RNA结合基序蛋白25; 心力衰竭
Keywords:
Alternative splicing; RNA binding motif protein20; RNA binding motif protein24; RNA binding motif protein25; Heart failure
DOI:
10.16806/j.cnki.issn.1004-3934.2025.04.010
摘要:
可变剪接（AS）是一种转录后机制，通过单一基因生成多样的蛋白质异构体，其主要功能是移除内含子并连结外显子，进而形成成熟的信使RNA（mRNA）。RNA结合蛋白(RBP)，是一类伴随RNA的调控代谢过程，与RNA结合蛋白质（RBP）的总称，是调控AS的关键因素。它们通过识别特定的序列元素并绑定到前信使RNA(pre-mRNA）上，从而影响剪接位点的选择，进而导致一些疾病相关基因的异常表达或功能失调。RNA结合基序蛋白（RBM）是RBP家族中的重要一类，它在心力衰竭中通过调控心肌细胞AS模式，从而发挥重要作用。
Abstract:
Alternative splicing(AS) is a post-transcriptional mechanism that generates diverse protein isoforms from a single gene, its main function is to remove introns and link exons to form mature messenger RNA( mRNA). RNA binding protein(RBP) are a class of proteins that regulate the metabolic process of RNA binding and are collectively referred to as proteins that bind to RNA. They are a key factor in regulating AS. They affect the choice of splicing sites by recognizing specific sequence elements and binding to the precursor mRNA(pre-mRNA）. This leads to abnormal expression or dysfunction of some disease-related genes. RNA binding motif protein(RBM) are an important class of RBP, and they play an important role in heart failure by regulating the AS pattern of cardiomyocytes.

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更新日期/Last Update: 2025-05-16