[1]于超 许文胜 贾小娥 刘锦龙 刘友 王艳芳 王崴 徐宏蕊 张涛.微RNA-细胞焦亡信号轴调控心肌缺血再灌注损伤的研究进展[J].心血管病学进展,2025,(2):141.[doi:10.16806/j.cnki.issn.1004-3934.2025.02.011]
　YU Chao,XU Wensheng,JIA Xiaoe,et al.MicroRNA Cell Poptosis Signaling Axis Regulation of Myocardial Ischemia Reperfusion Injury[J].Advances in Cardiovascular Diseases,2025,(2):141.[doi:10.16806/j.cnki.issn.1004-3934.2025.02.011]
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微RNA-细胞焦亡信号轴调控心肌缺血再灌注损伤的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年2期
页码:
141
栏目:
综述
出版日期:
2025-02-25

文章信息/Info

Title:
MicroRNA Cell Poptosis Signaling Axis Regulation of Myocardial Ischemia Reperfusion Injury
作者:
于超1 许文胜2 贾小娥1 刘锦龙1 刘友1 王艳芳1 王崴2 徐宏蕊3 张涛1
(1.内蒙古科技大学包头医学院基础医学与法医学院,内蒙古 包头 014000;2．内蒙古科技大学包头医学院附属第一医院,内蒙古 包头 014000;3．内蒙古科技大学包头医学院医学技术与麻醉学院,内蒙古 包头 014000)
Author(s):
YU Chao1; XU Wensheng2; JIA Xiaoe1; LIU Jinlong1; LIU You1; WANG Yanfang1; WANG Wei2; XU Hongrui3; ZHANG Tao1
(1.School of Basic Medical Sciences and Forensic Medicine,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014000,Inner Mongolia,China;2.The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014000,Inner Mongolia,China3.School of Medical Technology and Anesthesiology,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014000,Inner Mongolia,China)
关键词:
微RNA; 靶点; 心肌细胞焦亡; 心肌缺血再灌注损伤
Keywords:
MicroRNA; Target points; Cardiac cell pyroptosis; Myocardial ischemia reperfusion injury
DOI:
10.16806/j.cnki.issn.1004-3934.2025.02.011
摘要:
心肌缺血再灌注损伤（MIRI）是由于缺血心肌血流恢复，导致再灌注区心肌细胞及周围血管显著的病理生理变化，其发病机制复杂，与氧自由基、焦亡、凋亡等息息相关，其中，焦亡是近年来发现并证实的一种新的程序性细胞死亡方式，特征为细胞膨胀至破裂，释放大量炎症因子，触发炎症反应。微RNA（miRNA）在细胞内具有重要的调节作用，主要通过打乱目标信使RNA（mRNA）的稳定性、抑制靶mRNA的翻译来对靶mRNA发挥调控作用；目前，大量的研究表明，miRNA可以介导心肌细胞焦亡通路，减轻再灌注损伤程度。现综述主要以miRNA、心肌细胞焦亡、MIRI为切入点，以三者之间的相互作用关系做系统回顾，为MIRI的治疗提供新的方向。
Abstract:
Myocardial ischemia-reperfusion injury (MIRI) is due to the recovery of blood flow in ischemic myocardium, resulting in significant pathophysiological changes in cardiomyocytes and peripheral blood vessels in the reperfused area. Its pathogenesis is complex, closely related to oxygen free radicals, pyroptosis, apoptosis, etc., of which, pyroptosis is a new mode of programmed cell death that has been discovered and demonstrated in recent years, characterized by the expansion of the cells to the extent that they rupture, releasing a large amount of inflammatory factors and triggering an inflammatory response. MicroRNAs (miRNAs) play an important role in intracellular regulation, mainly by disrupting the stability of target messenger RNAs (mRNAs) and inhibiting the translation of target mRNAs; at present, a large number of studies have shown that miRNAs can mediate the pathway of myocardial cell pyroptosis and alleviate the degree of reperfusion injury. The present review focuses on miRNA-, cardiomyocyte pyroptosis-, and MIRI as the entry point to make a systematic review of the interactions among the three to provide a new direction for treating MIRI

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更新日期/Last Update: 2025-03-11