[1]柴雪祯 曹中伟 ?/html>.胰岛素样生长因子2受体在曲妥珠单抗治疗乳腺癌相关心脏毒性中的作用与机制研究[J].心血管病学进展,2025,(1):51.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.012]
 CHAI Xuezhen,CAO Zhongwei.Role and Mechanism of Insulin-Like Growth Factor 2 Receptor in Cardiotoxicity Associated with Trastuzumab Treatment of Breast Cancer[J].Advances in Cardiovascular Diseases,2025,(1):51.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.012]
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胰岛素样生长因子2受体在曲妥珠单抗治疗乳腺癌相关心脏毒性中的作用与机制研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年1期
页码:
51
栏目:
综述
出版日期:
2025-01-25

文章信息/Info

Title:
Role and Mechanism of Insulin-Like Growth Factor 2 Receptor in Cardiotoxicity Associated with Trastuzumab Treatment of Breast Cancer
作者:
柴雪祯1 曹中伟 2?/html>
?1.内蒙古医科大学研究生学院,内蒙古 呼和浩特 010110;2.内蒙古自治区人民医院甲状腺乳腺疝外科,内蒙古 呼和浩特 010010)
Author(s):
CHAI Xuezhen1CAO Zhongwei2
(1.College of Graduate Studies,Inner Mongolia Medical University,Huhhot 010110,Inner Mongolia,China;2.Department of Thyroid and Breast Hernia Surgery,Inner Mongolia Autonomous Region People’s Hospital,Huhhot 010010,Inner Mongolia,China)
关键词:
乳腺癌曲妥珠单抗人表皮生长因子受体2胰岛素样生长因子2受体心脏毒性
Keywords:
Breast cancerTrastuzumabHuman epidermal growth factor receptor-2Insulin-like growth factor 2 receptorCardiotoxicity
DOI:
10.16806/j.cnki.issn.1004-3934.2025.01.012
摘要:
心脏毒性是曲妥珠单抗治疗人表皮生长因子受体2阳性乳腺癌患者最常见的副作用,但其具体机制目前尚不清楚。胰岛素样生长因子2受体(IGF-2R)是一种广泛表达的多功能跨膜蛋白,其表达水平与心肌细胞病理损害的严重程度密切相关,且IGF-2R在乳腺癌患者的血清学中表达含量增加。现综述曲妥珠单抗与IGF-2R各自引发心脏毒性的机制,并分析二者间潜在的关联性,为阐明曲妥珠单抗引发心脏毒性的机制提供新思路。
Abstract:
Cardiotoxicity is the most frequent side effect of trastuzumab in patients with human epidermal growth factor receptor-2-positive breast cancer,but the exact mechanism is currently unknown. Insulin-like growth factor 2 receptor (IGF-2R) is a widely expressed multifunctional transmembrane protein ,and its expression level is closely related to the severity of pathological damage of cardiomyocytes,and increased expression of IGF-2R in the serum of breast cancer patients. This article reviews the mechanism of cardiotoxicity induced by trastuzumab and IGF-2R respectively,and analyzes the potential correlation between them ,providing new ideas for elucidating the mechanism of cardiotoxicity induced by trastuzumab

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更新日期/Last Update: 2025-02-26