[1]杜康 张育大 陈玺全 刘盼 杨颖.卵圆孔未闭相关疾病及封堵术研究进展[J].心血管病学进展,2025,(1):55.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.013]
　DU Kang,ZHANG Yuda,CHEN Xiquan,et al.Diseases Related to Patent Foramen Ovale and Its Closure[J].Advances in Cardiovascular Diseases,2025,(1):55.[doi:10.16806/j.cnki.issn.1004-3934.2025.01.013]
点击复制

卵圆孔未闭相关疾病及封堵术研究进展()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2025年1期
页码:
55
栏目:
综述
出版日期:
2025-01-25

文章信息/Info

Title:
Diseases Related to Patent Foramen Ovale and Its Closure
作者:
杜康1; 2 张育大1 陈玺全2 刘盼2 杨颖1
(1.川北医学院附属医院心血管内科,四川 南充 637000;2.广元市第一人民医院心血管内科,四川 广元 628000)
Author(s):
DU Kang1; 2; ZHANG Yuda1; CHEN Xiquan2; LIU Pan2; YANG Ying1
(Cardiovascular Department of Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,ChinaCardiovascular Department of Guangyuan First People’s Hospital,Guangyuan,Sichuan 628000,China)
关键词:
卵圆孔未闭; 卵圆孔未闭相关疾病; 封堵术
Keywords:
Patent foramen ovale; Diseases related to patent foramen ovale; Closure
DOI:
10.16806/j.cnki.issn.1004-3934.2025.01.013
摘要:
卵圆孔未闭（PFO）是一种常见的结构异常性先天性心脏病，普通人群中约25%的PFO。既往认为PFO是一种良性改变而对其缺乏关注，现大量研究已证实PFO与隐源性脑卒中、偏头痛、减压病、晕厥等存在关联，最新报告称也可能与癫痫、心绞痛等有关，其相关疾病谱在不断增加。针对PFO相关疾病的治疗，研究显示封堵术效果较好且可降低某些疾病的复发风险，但其安全性与有效性尚不完全清楚。现对PFO相关疾病及封堵术效果的最新研究进展做一综述。
Abstract:
Patent foramen ovale(PFO) is a common congenital heart disease with structural abnormalities,and about twenty-five percent of the general population have PFO. In the past,PFO was considered a benign change and lacked attention. Presently,a large number of studies have confirmed that PFO is associated with cryptogenic stroke,migraine,decompression sickness,syncope,etc. The latest reports show that it may also be related to epilepsy,angina pectoris,etc,and its spectrum of related diseases is increasing. Regarding the treatment of diseases related to patent foramen ovale,studies have shown that closure has good therapeutic effects and can reduce the recurrence rate of certain diseases,but its safety and effectiveness are not yet fully understood. This article summarizes the latest literature reports on diseases related to patent foramen ovale and closure effects.

参考文献/References:

[1] Teshome MK,Najib K,Nwagbara CC,et al. Patent foramen ovale:a comprehensive review[J]. Curr Probl Cardiol,2020,45(2):100392.
[2] Jin P,Jiao P,Feng J,et al. The predictive value of abnormal electrocardiogram for patent foramen ovale:a retrospective study[J]. Clin Cardiol,2023,46(12):1504-1510.
[3] Lee S,Kim IC,Kim YD,et al. The role of cardiac CT throughout the full cardiac cycle in diagnosing patent foramen ovale in patients with acute stroke[J]. Eur Radiol,2021,31(12):8983-8990.
[4] Rinkel LA,Bouma BJ,Boekholdt SM,et al. Detection of patent foramen ovale in patients with ischemic stroke on prospective ECG-gated cardiac CT compared to transthoracic echocardiography[J]. J Neurol,2023,270(7):3537-3542.
[5] Maggiore P,Bellinge J,Chieng D,et al. Ischaemic stroke and the echocardiographic “bubble study”:are we screening the right patients?[J]. Heart Lung Circ,2019,28(8):1183-1189.
[6] Lee PH,Song JK,Kim JS,et al. Cryptogenic stroke and high-risk patent foramen ovale:The DEFENSE-PFO Trial[J]. J Am Coll Cardiol,2018,71(20):2335-2342.
[7] Abdelaziz HK,Saad M,Abuomara HZ,et al. Long-term outcomes of patent foramen ovale closure or medical therapy after cryptogenic stroke:a meta-analysis of randomized trials[J]. Catheter Cardiovasc Interv,2018,92(1):176-186.
[8] Sondergaard L,Kasner SE,Rhodes JF,et al. Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke[J]. N Engl J Med,2017,377(11):1033-1042.
[9] Lee PH,Kim JS,Song JK,et al. Device closure or antithrombotic therapy after cryptogenic stroke in elderly patients with a high-risk patent foramen ovale[J]. J Stroke,2024,26(2):242-251.
[10] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 卵圆孔未闭规范化诊疗中国专家共识[J]. 中华心血管病杂志,2024,52(4):369-383.
[11] 余江月,邹永光,李鹏飞,等. 经颅多普勒超声声学造影联合Hcy、NLR对卵圆孔未闭合并隐源性脑卒中患者的预测价值[J]. 武汉大学学报(医学版),2024.1-5[2024-09-25].https://doi.org/10.14188/j.1671-8852.2023.0692.
[12] Park S,Kwon B,Oh JK,et al. Risk of recurrent ischemic stroke in patients with patent foramen ovale:the role of D-dimer[J]. J Stroke Cerebrovasc Dis,2023,32(9):107246.
[13] Stovner LJ,Hagen K,Linde M,et al. The global prevalence of headache:an update,with analysis of the influences of methodological factors on prevalence estimates[J]. J Headache Pain,2022,23(1):34.
[14] Zhou G,Liu A,Zhang Y,et al. Study on the correlation between patent foramen ovale and migraine based on meta analysis[J]. Altern Ther Health Med,2024:AT10801. Epub ahead of print.?
[15] Yan S,Wang N,Liu H,et al. Patent Foramen Ovale Closure for Migraineurs with Massive Right-to-Left Shunt and White Matter Lesions: An Exploration on Curative Effects[J]. Altern Ther Health Med, 2024,30(11):160-165.
[16] Elbadawi A,Barssoum K,Abuzaid AS,et al. Meta-analysis of randomized trials on percutaneous patent foramen ovale closure for prevention of migraine[J]. Acta Cardiol,2019,74(2):124-129.
[17] Tobis JM,Charles A,Silberstein SD,et al. Percutaneous closure of patent foramen ovale in patients with migraine:The PREMIUM Trial[J]. J Am Coll Cardiol,2017,70(22):2766-2774.
[18] Mattle HP,Evers S,Hildick-Smith D,et al. Percutaneous closure of patent foramen ovale in migraine with aura,a randomized controlled trial[J]. Eur Heart J,2016,37(26):2029-2036.
[19] Dowson A,Mullen MJ,Peatfield R,et al. Migraine Intervention With STARFlex Technology (MIST) trial:a prospective,multicenter,double-blind,sham-controlled trial to evaluate the effectiveness of patent foramen ovale closure with STARFlex septal repair implant to resolve refractory migraine headache[J]. Circulation,2008,117(11):1397-1404.
[20] Zi-Yang Y,Hezhi L,Dongling L,et al. Rationale and design of the SPRING trail:effectivity and safety of Pfo closuRe vs medIcine in alleviatiNg migraine,a multicenter,randomized and open-label trail[J]. BMC Cardiovasc Disord,2024,24(1):198.
[21] Mojadidi MK,Kumar P,Mahmoud AN,et al. Pooled analysis of PFO occluder device trials in patients with PFO and migraine[J]. J Am Coll Cardiol,2021,77(6):667-676.
[22] Pristipino C,Germonpre P,Toni D,et al. European position paper on the management of patients with patent foramen ovale. PartⅡ-Decompression sickness,migraine,arterial deoxygenation syndromes and select high-risk clinical conditions[J]. EuroIntervention,2021,17(5):e367-e375.
[23] Guo ZN,Qu Y,Gao Y,et al. Changes in cerebral autoregulation,stroke-related blood biomarkers,and autonomic regulation after patent foramen ovale closure in severe migraine patients[J]. CNS Neurosci Ther,2023,29(10):3031-3042.
[24] Germonpre P,Lafere P,Portier W,et al. Increased risk of decompression sickness when diving with a right-to-left shunt:results of a prospective single-blinded observational study (The “Carotid Doppler”Study)[J]. Front Physiol,2021,12:763408.
[25] Lee HJ,Lim DS,Lee J,et al. Decompression illness in divers with or without patent foramen ovale:a cohort study[J]. Ann Intern Med,2023,176(7):934-939.
[26] Honek J,Sramek M,Honek T,et al. Screening and risk stratification strategy reduced decompression sickness occurrence in divers with patent foramen ovale[J]. JACC Cardiovasc Imaging,2022,15(2):181-189.
[27] Lee HJ,Lim DS,Kang YC. Recurrent decompression illness even after the closure of patent foramen ovale in a diver[J]. JACC Case Rep,2023,5:101687.
[28] Hexdall EJ,Cooper JS. Patent foramen ovale in diving. 2024 Apr 30. In: StatPearls [Internet]. Treasure Island(FL): StatPearls Publishing;2024 Jan-. PMID:28613763.
[29] Zhang B,Li D,Song A,et al. Characteristics of patent foramen ovale:analysis from a single center[J]. Cardiol Res Pract,2022,2022:5430598.
[30] Shehata A,Nasser A,Mohsen A,et al. Prevalence and characteristics of patent foramen ovale in a sample of Egyptian population:a computed tomography study[J]. Egypt Heart J,2024,76(1):73.
[31] Zou R,Wang S,Liu P,et al. The association between patent foramen ovale and unexplained syncope in pediatric patients[J]. Ital J Pediatr,2024,50(1):2.
[32] Wang X,Liu X,Zheng L,et al. Correlation between percutaneous patent foramen ovale closure and recurrence of unexplained syncope[J]. Front Neurol,2023,14:1104621.
[33] Salas-Pacheco JL. [Mechanisms of platypnea-orthodeoxia syndrome][J]. Arch Cardiol Mex,2022,92(2):274-282.
[34] Agrawal A,Palkar A,Talwar A. The multiple dimensions of Platypnea-Orthodeoxia syndrome:a review[J]. Respir Med,2017,129:31-38.
[35] Gama ECA,Luz A,Oliveira F,et al. Platypnoea orthodeoxia syndrome and patent foramen ovale closure:single-centre experience and long-term follow-up[J]. Heart Lung Circ,2022,31(11):1547-1552.
[36] Cao Q,Shen Y,Hou Z,et al. The relationship between patent foramen ovale and unexplained dizziness:a prospective analysis in China[J]. Neuropsychiatr Dis Treat,2022,18:1495-1505.
[37] 徐扬舟,李亚萍,阳衡,等. 神经系统发作性疾病与卵圆孔未闭关系的临床研究[J]. 中国全科医学,2022,25(24):3018-3021.
[38] Tang Y,Ji S,Li H,et al. Association of patent foramen ovale with epilepsy:a hospital-based case-control study[J]. Epilepsia Open,2023,8(3):1075-1083.
[39] Ravi D,Parikh RV,Aboulhosn J,et al. A new syndrome of patent foramen ovale inducing vasospastic angina and migraine[J]. JACC Case Rep,2023,28:102132.
[40] Zhai X,Jiao R,Ni A,et al. Case report:anxiety and depression as initial symptoms in a patient with acute hypoxia and patent foramen ovale[J]. Front Psychiatry,2023,14:1229995.
[41] Pristipino C,Sievert H,D’Ascenzo F,et al. European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism[J]. Eur Heart J,2019,40(38):3182-3195.
[42] Apostolos A,Tsiachris D,Drakopoulou M,et al. Atrial fibrillation after patent foramen ovale closure:incidence,pathophysiology,and management[J]. J Am Heart Assoc,2024,13(9):e34249.
[43] Goldsweig AM,Deng Y,Yao X,et al. Approval,evidence,and“Off-Label”device utilization:the patent foramen ovale closure story[J]. Circ Cardiovasc Qual Outcomes,2024,17(1):e010200.

相似文献/References:

[1]田晓光 陈武 徐琨 刘晓芳.经胸超声心动图声学造影与对比增强经颅多普勒对卵圆孔未闭右向左分流的筛查价值[J].心血管病学进展,2022,(4):371.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.020]
　TIAN Xiaoguang,CHEN WuXU Kun,LIU Xiaofang.The Screening Value of Contrast Transthoracic Echocardiography and Contrast-Enhanced Transcranial Doppler in the Right to Left Shunt of Patent Foramen Ovale[J].Advances in Cardiovascular Diseases,2022,(1):371.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.020]
[2]刘瑶 张丽娟 雍永宏 孙海建.斜卧呼吸-直立性低氧血症综合征机制与诊疗研究进展[J].心血管病学进展,2023,(8):752.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.018]
　LIU Yao,ZHANG Lijuan,YONG Yonghong,et al.Progress on the Mechanism,Diagnosis and Treatment of Platypnea-Orthodeoxia Syndrome[J].Advances in Cardiovascular Diseases,2023,(1):752.[doi:10.16806/j.cnki.issn.1004-3934.2023.08.018]
[3]王华 陈科宇 秦永文 白元.新型卵圆孔未闭封堵器的研制及临床应用进展[J].心血管病学进展,2023,(9):781.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.004]
　WANG Hua,CHEN Keyu,QIN Yongwen,et al.Design and Clinical Practice of Novel Patent Foramen Ovale Occluders[J].Advances in Cardiovascular Diseases,2023,(1):781.[doi:10.16806/j.cnki.issn.1004-3934.2023.09.004]
[4]郭银吉 孙永红.卵圆孔未闭与偏头痛相关性研究性进展[J].心血管病学进展,2025,(2):124.[doi:10.16806/j.cnki.issn.1004-3934.2025.02.007]
　GUO Yinji,SUN Yonghong.Research Progress of Patent Foramen Ovale and Migraine[J].Advances in Cardiovascular Diseases,2025,(1):124.[doi:10.16806/j.cnki.issn.1004-3934.2025.02.007]

更新日期/Last Update: 2025-02-26