[1]张毅 顾铭霞.ADRB1、ACE基因多态性与左心室肥厚的相关性研究[J].心血管病学进展,2023,(7):664.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.020]
　ZHANG Yi,GU Mingxia.The Relationship of Gene Polymorphism in the 1-Adrenergic Receptor and Angiotensin Converting Enzyme with Left Ventricular Hypertrophy[J].Advances in Cardiovascular Diseases,2023,(7):664.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.020]
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ADRB1、ACE基因多态性与左心室肥厚的相关性研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年7期
页码:
664
栏目:
论著
出版日期:
2023-07-25

文章信息/Info

Title:
The Relationship of Gene Polymorphism in the 1-Adrenergic Receptor and Angiotensin Converting Enzyme with Left Ventricular Hypertrophy
作者:
张毅1 顾铭霞2
(1.南通大学附属医院心血管内科,南通,江苏,226006;2.南京市中心医院心血管内科,南京,江苏,211800)
Author(s):
ZHANG Yi1; GU Mingxia2
(1.Department of Cardiology,Affiliated Hospital of Nantong University,Nantong 226006,Jiangsu,China2. Department of Cardiology,Nanjing Central Hospital,Nanjing 211800,Jiangsu,China) E-mail1211341273@qq.com
关键词:
β1肾上腺素受体; 血管紧张素转换酶; 基因多态性; 左心室肥厚
Keywords:
1-adrenergic receptor; ?Angiotensin converting enzyme; ?Gene polymorphisms; ?Left ventricular hypertrophy
DOI:
10.16806/j.cnki.issn.1004-3934.2023.07.020
摘要:
目的 探讨原发性 高血压（EH）左心室肥厚（LVH）患者中β1肾上腺素能受体（ADRB1）、血管紧张素转换酶（ACE）基因多态性的作用。方法 根据《中国高血压防治指南》(2018年修订版)选取EH住院患者80例，对EH患者进行心脏超声检查分为LVH(LVH+)组33例和非LVH(LVH﹣)组47例。收集两组患者临床资料，取外周血使用基因芯片技术检测各自的基因多态性位点，比较两组患者性别、年龄、体重指数、肝肾功能、血糖、血脂以及基因型和等位基因频率。结果 两组间性别、年龄、体重指数、空腹血糖、 高密度脂蛋白胆固醇、肝功能及血压等比较无显著性差异（P＞0.05）。LVH+组ADRB1 CC基因型及C等位基因频率高于LVH﹣组（P＜0.05），LVH+组ACE ID基因型频率及D等位基因频率高于LVH﹣组（P＜0.05）。ADRB1与ACE敏感基因型联合分析，联合基因型分布频率在LVH+组与LVH﹣组间无显著性差异（P＞0.05）。结论 ADRB1 C/G多态性与LVH发病相关，CC基因型及C等位基因携带可能是LVH发病危险因素；ACE I/D多态性与LVH发病相关，ID基因型及D等位基因携带可能是LVH发病危险因素；ADRB1与ACE基因的敏感基因型联合作用对LVH发病可能无协同作用。
Abstract:
Objective To investigate the role of ADRB1 and ACE gene polymorphisms in patients with essential hypertension (EH) and left ventricular hypertrophy (LVH). Methods According to Chinese Guidelines for Hypertension Prevention and Treatment (2018 Revision) ,80 inpatients with EH were selected and divided into LVH group (33 cases) and non-LVH group (47 cases) by cardiac ultrasound.?Clinical data of the two groups were collected ,and peripheral blood was collected to detect gene polymorphism of the two groups using gene chip technology. Gender,age,body mass index (BMI),liver and kidney function,blood glucose,blood lipid,genotype and allele frequency of the two groups were compared. Results There were no significant differences in gender,age,BMI,fasting blood glucose,high-density lipoprotein cholesterol ,liver function and blood pressure between the two groups (P＞0.05).The frequency of ADRB1 CC genotype and C allele in LVH+ group was higher than that in LVH- group ( P＜0.05),the frequency of ACE ID genotype and D allele in LVH+ group were higher than those in LVH- group ( P＜0.05).?Combined analysis of ADRB1 and ACE sensitive genotypes showed no significant difference in distribution frequency between LVH+ group and LVH- group ( P＞0.05). Conclusion ADRB1 C/G polymorphism is associated with LVH ,CC genotype and C allele may be risk factors for LVH.?ACE I/D polymorphism is associated with LVH,and ID genotype and D allele may be risk factors for LVH.?The sensitive genotype’s combination of ADRB1 and ACE gene may have no synergistic effect on LVH.

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更新日期/Last Update: 2023-08-18