[1]孔凡玲 刘慧 程维礼 张莱 陶琴 张郁青.Sfrp5与心血管疾病的相关性研究进展[J].心血管病学进展,2023,(10):939.[doi:10.16806/j.cnki.issn.1004-3934.2023.10.017]
　KONG FanlingLIU HuiCHENG WeiliZHANG LaiTAO QinZHANG Yuqing.Progress of the Association of Sfrp5 with Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2023,(10):939.[doi:10.16806/j.cnki.issn.1004-3934.2023.10.017]
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Sfrp5与心血管疾病的相关性研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年10期
页码:
939
栏目:
综述
出版日期:
2023-10-25

文章信息/Info

Title:
Progress of the Association of Sfrp5 with Cardiovascular Diseases
作者:
孔凡玲 刘慧 程维礼 张莱 陶琴 张郁青
(南京医科大学附属江宁医院心内科,南京 211100)
Author(s):
KONG FanlingLIU HuiCHENG WeiliZHANG LaiTAO QinZHANG Yuqing
?Department of Cardiology ,The Affiliated Jiangning Hospital of Nangjing Medical University,Nanjing 211100,China)
关键词:
分泌型卷曲相关蛋白; 慢性冠脉疾病; 急性冠脉综合征; 心力衰竭; 高血压; Wnt信号通路
Keywords:
Secreted frizzled-related protein; Chronic coronary artery disease; Acute coronary syndrome; Heart failure; Hypertension; Wnt signaling pathway
DOI:
10.16806/j.cnki.issn.1004-3934.2023.10.017
摘要:
近年来研究发现，分泌型卷曲相关蛋白（Sfrp）做为一种抗炎脂肪因子家族，参与体内多种疾病的发生和发展，包括心血管系统、内分泌与代谢系统、血液系统等，并在疾病的预后转归中起到重要作用。Sfrp5作为Sfrp的一员，在体内主要依赖Wnt/β-catenin非经典型信号通路发挥其独特的生物学效应。目前越来越多的证据表明，Sfrp5与心血管疾病的发生及预后密切相关，Sfrp5有望成为预防和治疗心血管疾病的新靶点。现对Sfrp5与心血管疾病的相关性做一综述。
Abstract:
The Secreted Frizzled-Related Proteins (Sfrp),a family of anti-inflammatory adipokines,have been found to be involved in the development of various diseases in vivo,including cardiovascular system,endocrine and metabolic system,and hematological system,and play an important role in the prognosis of these diseases. Sfrp5,as a member of the Sfrp,relies mainly on the Wnt/β-catenin atypical signaling pathway to exert its unique biological effects in vivo. There is growing evidence that Sfrp5 is closely associated with the development of cardiovascular diseases, and Sfrp5 is expected to be a new target for the prevention and treatment of cardiovascular diseases. The aim of this article is to provide a review of the relevance of Sfrp5 to cardiovascular diseases

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更新日期/Last Update: 2023-11-15