[1]郭梦阳 王守富 邢冬梅.DNA甲基化与原发性高血压关系研究进展[J].心血管病学进展,2023,(7):631.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.013]
　GUO Mengyang,WANG Shoufu,XING Dongmei.Relationship Between DNA Methylation and Essential Hypertension[J].Advances in Cardiovascular Diseases,2023,(7):631.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.013]
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DNA甲基化与原发性高血压关系研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年7期
页码:
631
栏目:
综述
出版日期:
2023-07-25

文章信息/Info

Title:
Relationship Between DNA Methylation and Essential Hypertension
作者:
郭梦阳1 王守富2 邢冬梅3
(1.河南中医药大学,河南 郑州 450046;2.河南省中西医结合医院,河南 郑州 450003;3.河南中医药大学第一附属医院,河南 郑州 450000)
Author(s):
GUO Mengyang1;  WANG Shoufu2;  XING Dongmei3
(1.Henan University of Chinese Medicine, Zhengzhou 450046, Henan,China; 2.Henan Integrated Traditional and Western Medicine Hospital, Zhengzhou 450003,Henan,China 3.The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000,Henan,China)
关键词:
DNA甲基化; 表观遗传学; 原发性高血压
Keywords:
DNA methylation; Epigenetics; Essential hypertension
DOI:
10.16806/j.cnki.issn.1004-3934.2023.07.013
摘要:
表观遗传学在原发性高血压（EH）的发病机制中发挥重要的作用，DNA甲基化是表观遗传学最明确的修饰方式，与EH的病理过程密切相关。肾素-血管紧张素系统、水盐代谢、血管内皮功能、炎性因子等相关基因启动子区域发生异常甲基化可调控基因表达，使血压升高。了解特定基因甲基化修饰在EH发生和发展中的作用，将为EH的预防和诊疗提供新的靶点。现就特定基因甲基化修饰在EH中的分子机制进行综述。
Abstract:
Epigenetics plays an important role in the pathogenesis of essential hypertension(EH). DNA methylation is the most explicit modification of epigenetics and is closely related to the pathological process of EH. Abnormal methylation in the promoter regions of genes related to the renin-angiotensin system,water and salt metabolism,vascular endothelial function,and inflammatory factors can regulate gene expression and increase blood pressure. Understanding the role of specific gene methylation modification in the occurrence and ————————————————基金项目：国家自然科学基金（81703889）；河南省重点研发与推广专项项目（科技攻关）（182102311155）；河南省中医药专项研究课题（2017ZY2038,2018JDZX008,2022JDZX077）；河南省中医专科诊疗中心建设项目（豫卫中医函［2020］63号）通信作者：王守富，E-mail：shoufuwang@126.comdevelopment of EH will provide new targets for the prevention,diagnosis and treatment of EH. This paper mainly reviews the molecular mechanism of specific gene methylation modification in EH

参考文献/References:

[1] Chaudhary M. Novel methylation mark and essential hypertension[J]. J Genet Eng Biotechnol, 2022,20(1):11.

[2] Ma S,Yang L,Zhao M,et al. Trends in hypertension prevalence,awareness,treatment and control rates among Chinese adults,1991-2015[J]. J Hypertens,2021,39(4):740-748.

[3] Bao M,Wang L. The longitudinal trend of hypertension prevalence in Chinese adults from 1959 to 2018:a systematic review and meta-analysis[J]. Ann Palliat Med,2020,9(5):2485-2497.

[4] Chaudhary M. Novel methylation mark and essential hypertension[J]. J Genet Eng Biotechnol,2022,20(1):11.

[5] Ahuja YR,Sharma S,Mohan V. Cardiovascular diseases:Interplay of epigenetics[J]. Clin Exp Hypertens,2017,39(1):1-7.

[6] Sabia C,Picascia A,Grimaldi V,et al. The epigenetic promise to improve prognosis of heart failure and heart transplantation[J]. Transplant Rev (Orlando),2017,31(4):249-256.

[7] Nishiyama A,Nakanishi M. Navigating the DNA methylation landscape of cancer[J]. Trends Genet,2021,37(11):1012-1027.

[8] Uddin MDM,Nguyen NQH,Yu B,et al. Clonal hematopoiesis of indeterminate potential,DNA methylation,and risk for coronary artery disease[J]. Nat Commun,2022,13(1):5350.

[9] Schubeler D. Function and information content of DNA methylation[J]. Nature,2015,517(7534):321-326.

[10] Moore LD,Le T,Fan G. DNA methylation and its basic function[J]. Neuropsychopharmacology,2013,38(1):23-38.

[11] Xiang D,Xiao J,Fu L,et al. DNA methylation of the Tacr2 gene in a CUMS model of depression[J]. Behav Brain Res,2019,365:103-109.

[12] Smolarek I,Wyszko E,Barciszewska AM,et al. Global DNA methylation changes in blood of patients with essential hypertension[J]. Med Sci Monit,2010,16(3):R149-R155.

[13] Richard MA,Huan T,Ligthart S,et al. DNA methylation analysis identifies loci for blood pressure regulation[J]. Am J Hum Genet,2017,101(6):888-902.

[14] Huang Y,Ollikainen M,Muniandy M,et al. Identification,heritability,and relation with gene expression of novel DNA methylation loci for blood pressure[J]. Hypertension,2020,76(1):195-205.

[15] Forrester SJ,Booz GW,Sigmund CD,et al. Angiotensin Ⅱ signal transduction:an update on mechanisms of physiology and pathophysiology[J]. Physiol Rev,2018,98(3):1627-1738.

[16] Wang F,Demura M,Cheng Y,et al. Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene[J]. Hypertension,2014,63(2):281-288.

[17] Takeda Y,Demura M,Yoneda T,et al. DNA methylation of the angiotensinogen gene,AGT,and the aldosterone synthase gene,CYP11B2 in cardiovascular diseases[J]. Int J Mol Sci,2021,22(9) :4587.

[18] Fan R,Mao SQ, Gu TL,et al. Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension[J]. Mol Med Rep,2017,15(6):3905-3911.

[19] Kawarazaki W,Fujita T. Kidney and epigenetic mechanisms of salt-sensitive hypertension[J]. Nat Rev Nephrol,2021,17(5):350-363.

[20] Lillycrop KA,Slater-Jefferies JL,Hanson MA,et al. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications[J]. Br J Nutr,2007,97(6):1064-1073.

[21] Takeda Y,Demura M,Wang F,et al. Epigenetic regulation of aldosterone synthase gene by sodium and angiotensin Ⅱ[J]. J Am Heart Assoc,2018,7(10):e008281.

[22] Xu JC,Lytle C,Zhu TT,et al. Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter[J]. Proc Natl Acad Sci U S A,1994,91(6):2201-2205.

[23] Cho HM,Lee HA,Kim HY,et al. Recruitment of specificity protein 1 by CpG hypomethylation upregulates Na+-K+-2Cl- cotransporter 1 in hypertensive rats[J]. J Hypertens,2013,31(7):1406-1413.

[24] Zhang JR,Hu WN,Li CY. A review of the epidemiological evidence for adducin family gene polymorphisms and hypertension[J]. Cardiol Res Pract,2019,2019:7135604.

[25] Bayoumy NMK,El-Shabrawi MM,Leheta OF,et al. α-Adducin gene promoter DNA methylation and the risk of essential hypertension[J]. Clin Exp Hypertens,2017,39(8):764-768.

[26] Pizzolo F,Friso S,Morandini F,et al. Apparent mineralocorticoid excess by a novel mutation and epigenetic modulation by HSD11B2 promoter methylation[J]. J Clin Endocrinol Metab,2015,100(9):E1234-E1241.

[27] Friso S,Pizzolo F,Choi SW,et al. Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension[J]. Atherosclerosis,2008,199(2):323-327.

[28] Li J,Zhu J,Ren L,et al. Association between NPPA promoter methylation and hypertension: results from Gusu cohort and replication in an independent sample[J]. Clin Epigenetics,2020,12(1):133.

[29] Solak Y,Afsar B,Vaziri ND,et al. Hypertension as an autoimmune and inflammatory disease[J]. Hypertens Res,2016,39(8):567-573.

[30] Mullick A E,Soldau K,Kiosses WB,et al. Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events[J]. J Exp Med,2008,205(2):373-383.

[31] Edfeldt K,Swedenborg J,Hansson GK,et al. Expression of toll-like receptors in human atherosclerotic lesions:a possible pathway for plaque activation[J]. Circulation,2002,105(10):1158-1161.

[32] Mao S,Gu T,Zhong F,et al. Hypomethylation of the Toll-like receptor-2 gene increases the risk of essential hypertension[J]. Mol Med Rep,2017,16(1):964-970.

[33] Omar WFNW,Abdullah A,Talib NA,et al. Leucocytic DNA methylation of interleukin-6 promoter reduction in pre-hypertensive young adults[J]. Malays J Med Sci,2019,26(6):46-54.

[34] Ferrari L,Vicenzi M,Tarantini L,et al. Effects of physical exercise on endothelial function and DNA methylation[J]. Int J Environ Res Public Health, 2019,16(14):2530.

[35] Jin F,Li X,Wang Z,et al. Association of mitofusin 2 methylation and essential hypertension:a case-control study in a Chinese population[J]. Hypertens Res,2018,41(8):605-613.

[36] Zhang Y,Tang J,Li N,et al. Prenatal hypoxia induced ETBR activation and abnormal ROS signalling in pulmonary artery cells of rat offspring[J]. Reprod Toxicol,2021,105:91-100.

[37] Rexhaj E,Paoloni-Giacobino A,Rimoldi SF,et al. Mice generated by in vitro fertilization exhibit vascular dysfunction and shortened life span[J]. J Clin Invest,2013,123(12):5052-5060.

[38] Chen K,Sun Z. Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension[J]. Aging Cell,2018,17(4):e12762.

[39] Wang T,Lian G,Cai X,et al. Effect of prehypertensive losartan therapy on AT1R and ATRAP methylation of adipose tissue in the later life of highfatfed spontaneously hypertensive rats[J]. Mol Med Rep,2018,17(1):1753-1761.

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更新日期/Last Update: 2023-08-18