[1]蔡宇宸 姚弈伟 陈鑫.ADAMTS家族蛋白与主动脉瘤相关性的研究及进展[J].心血管病学进展,2022,(5):450-453，458.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.016]
　CAI Yuchen,YAO Yiwei,CHEN Xin.The Association of ADAMTS Family with Aortic Aneurysms[J].Advances in Cardiovascular Diseases,2022,(5):450-453，458.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.016]
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ADAMTS家族蛋白与主动脉瘤相关性的研究及进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年5期
页码:
450-453，458
栏目:
出版日期:
2022-05-25

文章信息/Info

Title:
The Association of ADAMTS Family with Aortic Aneurysms
作者:
蔡宇宸 姚弈伟 陈鑫
(南京医科大学附属南京医院心胸血管外科 南京市第一医院,江苏 南京 210002)
Author(s):
CAI Yuchen; YAO Yiwei; CHEN Xin
(Department of Cardiothoracic Vascular Surgery,Nanjing Hospital Affiliated to Nanjing Medical University,Nanjing First Hospital,Nanjing 210002,Jiangsu,China)
关键词:
主动脉瘤; ADAMTS; 细胞外基质; 血管平滑肌细胞
Keywords:
Aortic aneurysm; ADAMTS; Extracellular matrix; Vascular smooth muscle cell
DOI:
10.16806/j.cnki.issn.1004-3934.2022.05.016
摘要:
主动脉瘤是一种常见大血管疾病，可演变为主动脉夹层或主动脉破裂，导致患者死亡，且缺乏有效的早期筛查和干预的手段，其发病机制也较为复杂。ADAMTS家族蛋白是一类具有近似序列及结构域的金属蛋白酶，已被广泛证实在心血管系统疾病的多个环节发挥重要作用。现系统阐述ADAMTS1、ADAMTS4和ADAMTS7等家族成员与主动脉瘤的相关性，这种关联被多个细胞实验、动物实验以及人体组织学研究所证实。这为主动脉瘤的早期筛查及干预提供了新的可能性。
Abstract:
Aortic aneurysm is a common macrovascular disease,which can evolve into aortic dissection or aortic rupture,leading to patient death. There is a lack of effective means of early screening and intervention,and its pathogenesis is also complex. The ADAMTS family,also known as a disintegrin and metalloproteinase thrombospondin motifs,has been shown to play an important role in many aspects of cardiovascular disease. In this paper,we systematically describe the association of members such as ADAMTS1,ADAMTS4 and ADAMTS7 with aortic aneurysms. This association has been confirmed by several cellular experiments,animal experiments and human histological studies. This provides a new possibility for early screening and intervention of aortic aneurysm

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更新日期/Last Update: 2022-06-30