[1]邵亚兰 马继鹏 卢林鹤 熊祥 马燕燕 刘金成 杨剑.铁死亡与铁自噬在中的研究进展[J].心血管病学进展,2022,(9):787-790.[doi:10.16806/j.cnki.issn.1004-3934.2022.09.005]
 SHAO Yalan,MA Jipeng,LU Linhe,et al.Ferroptosis and Ferritinophagy in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2022,(9):787-790.[doi:10.16806/j.cnki.issn.1004-3934.2022.09.005]
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铁死亡与铁自噬在中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年9期
页码:
787-790
栏目:
出版日期:
2022-09-25

文章信息/Info

Title:
Ferroptosis and Ferritinophagy in Cardiovascular Disease
作者:
邵亚兰 马继鹏 卢林鹤 熊祥 马燕燕 刘金成 杨剑
(空军军医大学西京医院心血管外科,陕西 西安 710032)
Author(s):
SHAO YalanMA JipengLU LinheXIONG XiangMA YanyanLIU JinchengYANG Jian
(Department of Cardiovascular Surgery,Xijing Hospital,Air Force Medical University,Xian 710032,Shaanxi,China)
关键词:
铁死亡铁自噬核受体共激活因子4脂质过氧化心血管疾病
Keywords:
FerroptosisFerritinophagyNuclear receptor co-activator 4Lipid peroxidationCardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2022.09.005
摘要:
铁死亡是新近发现的一种铁依赖性可调节的细胞死亡形式,其在形态和调控机制上与细胞凋亡、细胞焦亡和细胞坏死性凋亡等细胞死亡形式显著不同。核受体共激活因子4介导的铁自噬能调节铁死亡。最新研究表明,铁死亡和铁自噬在多种心血管疾病(CVD)的病理机制中发挥至关重要的作用。因此,本综述系统性回顾了铁死亡和铁自噬的概念、生化特点以及在CVD发病机制中的具体病理分子机制,旨在通过明确铁死亡和铁自噬在CVD的最新研究进展为CVD的临床诊疗提供新思路和治疗靶点。
Abstract:
Ferroptosis is a newly discovered form of iron-dependent and regulated cell death,which is significantly different from apoptosis,pyroptosis and necroptosis in morphology and regulatory mechanism. Nuclear receptor co-activator 4-mediated ferritinophagy can regulate ferroptosis. Recent studies have shown that ferroptosis and ferritinophagy play crucial roles in the pathological mechanisms of various cardiovascular diseases(CVD). Therefore,in this review,we systematically reviewed the concepts,biochemical characteristics and specific pathological molecular mechanisms of ferroptosis and ferritinophagy in the pathogenesis of CVD,aiming to provide new ideas and therapeutic targets for the clinical diagnosis and treatment of CVD by clarifying the latest research progress of ferroptosis and ferritinophagy in CVD.

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备注/Memo

备注/Memo:
收稿日期:2022-02-28
基金项目:陕西省科技厅创新团队项目(2020TD-034)
更新日期/Last Update: 2022-10-24