[1]罗梦笛 何庆.心肺复苏后肠黏膜屏障功能受损机制的研究进展[J].心血管病学进展,2022,(3):241-244.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
　LUO Mengdi,HE Qing.Mechanism of Intestinal Mucosal Barrier Function Impairment after Cardiopulmonary Resuscitation[J].Advances in Cardiovascular Diseases,2022,(3):241-244.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
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心肺复苏后肠黏膜屏障功能受损机制的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年3期
页码:
241-244
栏目:
综述
出版日期:
2022-03-25

文章信息/Info

Title:
Mechanism of Intestinal Mucosal Barrier Function Impairment after Cardiopulmonary Resuscitation
文章编号:
202111104
作者:
罗梦笛 何庆
(西南交通大学临床医学院 西南交通大学附属医院 成都市第三人民医院,四川 成都 610031)
Author(s):
LUO Mengdi; HE Qing
(College of Clinical Medicine,Southwest Jiaotong University,The Affiliated Hospital of Southwest Jiaotong University,The Third People’s Hospital of Chengdu,Chengdu 610031,Sichuan,China)
关键词:
心肺复苏; 心脏骤停; 肠黏膜屏障
Keywords:
Cardiopulmonary resuscitation; Cardiac arrest; Intestinal mucosal barrier
DOI:
10.16806/j.cnki.issn.1004-3934.2022.03.000
摘要:
心脏骤停后进行心肺复苏已得到广泛应用，但其生存率仍然不高。肠黏膜屏障损伤是心肺复苏后导致患者死亡的重要原因之一。心肺复苏后，肠道对缺血缺氧极其敏感，可能引起缺血再灌注损伤，导致细菌移位、炎症反应以及肠道菌群紊乱等，进而引起肠黏膜屏障功能受损，最终发展为多器官功能障碍综合征，但其受损机制尚未完全清楚。因此，明确心肺复苏后肠黏膜屏障功能的受损机制有利于提高心肺复苏后患者的预后与转归。未来应对心肺复苏后肠黏膜屏障功能受损的机制进行更深入的探讨，为后续治疗提供理论基础。
Abstract:
Cardiopulmonary resuscitation(CPR) after cardiac arrest has been widely used,but its survival rate is still not high. Intestinal mucosal barrier injury is one of the important causes of patient death after CPR. After CPR,the intestine is extremely sensitive to ischemia and hypoxia,which may cause ischemia reperfusion injury,leading to bacterial translocation,inflammatory response and intestinal flora disorder,which in turn causes impaired intestinal mucosal membrane barrier function and eventually develops into multiple organ dysfunction syndrome,but the mechanism of impairment is not fully understood. Therefore,the mechanism of impaired intestinal mucosal barrier function after CPR should be clarified to improve the prognosis and regression of patients after CPR. The mechanism of impaired intestinal mucosal barrier function after CPR should be explored more deeply in the future to provide a theoretical basis for subsequent treatment

参考文献/References:


[1]Jalife J. The tornadoes of sudden cardiac arrest[J].?Nature,2018,555(7698):597-598.
[2]Qian J,Yang Z,Cahoon J,et al. Post-resuscitation intestinal microcirculation:its relationship with sublingual microcirculation and the severity of post-resuscitation syndrome[J]. Resuscitation,2014,85(6):833-839.
[3]Buckley A,Turner JR. Cell biology of tight junction barrier regulation and mucosal disease[J]. Cold Spring Harb Perspect Biol,2018,10(1):a029314.
[4]王希,廖吕钊,江荣林. 肠上皮细胞紧密连接蛋白的结构功能及其调节[J]. 浙江医学,2018,40(8):895-898.
[5]Cai R,Cheng C,Chen J,et al. Interactions of commensal and pathogenic microorganisms with the mucus layer in the colon[J]. Gut Microbes,2020,11(4):680-690.
[6]Chen J,Huang C,Wang J,et al. Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats[J]. PLoS One,2017,8(4):e0176583.
[7]Teltschik Z,Wiest R,Beisner J,et al. Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense[J]. Hepatology,2012,55(4):1154-1163.
[8]Li XY,He C,Zhu Y,et al. Role of gut microbiota on intestinal barrier function in acute pancreatitis[J].?World J Gastroenterol,2020,26(18):2187-2193.
[9]Hsieh CY,Osaka T,Moriyama E,et al. Strengthening of the intestinal epithelial tight junction by Bifidobacterium bifidum[J]. Physiol Rep,2015,3(3):e12327.
[10]Ahluwalia B,Magnusson MK,?hman L. Mucosal immune system of the gastrointestinal tract:maintaining balance between the good and the bad[J].?Scand J Gastroenterol, 2017,52(11):1185-1193.
[11]Korth U,Krieter H,Denz C,et al. Intestinal ischaemia during cardiac arrest and resuscitation:comparative analysis of extracellular metabolites by microdialysis[J]. Resuscitation,2003,58(2):209-217.
[12]Wang Z,Sun R,Wang G,et al. SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury[J]. Redox Biol,2020,28:101343.
[13]Funk CD. Prostaglandins and leukotrienes:advances in eicosanoid biology[J].?Science,2001,294(5548):1871-1875.
[14]Sasaki M,Joh T. Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant,protective agents[J].?J Clin Biochem Nutr,2007,40(1):1-12.
[15]李文静. 血红素氧合酶-1对心肺复苏后大鼠肠道屏障保护作用的研究[D].广东:中山大学,2009.
[16]El-Benna J,Hurtado-Nedelec M,Marzaioli V,et al. Priming of the neutrophil respiratory burst:role in host defense and inflammation[J]. Immunol Rev,2016,273(1):180-193.
[17]Grimaldi D,Guivarch E,Neveux N,et al. Markers of intestinal injury are associated with endotoxemia in successfully resuscitated patients[J]. Resuscitation,2013,84(1):60-65.
[18] Ghosh SS,Wang J,Yannie PJ,et al. Intestinal barrier dysfunction,LPS translocation,and disease development[J].?J Endocr Soc,2020,4(2):bvz039. [19]Leaphart CL,Tepas JJ 3rd. The gut is a motor of organ system dysfunction[J].?Surgery,2007,141(5):563-569.
[20]刘芳,刘敏,王峰,等. 一氧化碳释放分子2对心肺复苏大鼠复苏后肠屏障功能的影响[J].中国病理生理杂志,2019,35(2):346-352.
[21]Lu?YC,Yeh?WC,Ohashi?PS. LPS/TLR4 signal transduction pathway[J]. Cytokine,2008,42(2):145-151.
[22]Wang X,Li S,Chen M,et al. Activation of the nuclear receptor Fxr improves intestinal cell tolerance to ischemia-reperfusion injury[J]. Shock,2018,50(3):316-323.
[23]Ng CS,Wan S,Arifi AA,et al. Inflammatory response to pulmonary ischemia-reperfusion injury[J]. Surg Today,2006,36:205-214.
[24]Tian R,Tan JT,Wang RL,et al. The role of intestinal mucosa oxidative stress in gut barrier dysfunction of severe acute pancreatitis[J]. Eur Rev Med Pharmacol Sci,2013,17(3):349-355.
[25]Huang L,Zhang D,Han W,et al. High-mobility group box-1 inhibition stabilizes intestinal permeability through tight junctions in experimental acute necrotizing pancreatitis[J]. Inflamm Res,2019,68(8):677-689.
[26]Burger E,Araujo A,López-Yglesias A,et al. Loss of Paneth cell autophagy causes acute susceptibility to Toxoplasma gondii-mediated inflammation[J].?Cell Host Microbe,2018,23(2):177-190.e4.
[27]Wu MY,Yiang GT,Liao WT,et al. Current mechanistic concepts in ischemia and reperfusion injury[J].?Cell Physiol Biochem,2018,46(4):1650-1667.
[28]Hansson GC. Mucins and the microbiome[J].?Annu Rev Biochem,2020,89:769-793.
[29]Paradis T,Bègue H,Basmaciyan L,et al. Tight junctions as a key for pathogens invasion in intestinal epithelial cells[J].?Int J Mol Sci,2021,22(5):2506. [30]Martin-Gallausiaux C,Marinelli L,Blottière HM,et al. SCFA:mechanisms and functional importance in the gut[J].?Proc Nutr Soc,2021,80(1):37-49.
[31]Jackson DN,Theiss AL. Gut bacteria signaling to mitochondria in intestinal inflammation and cancer[J].?Gut Microbes,2020,11(3):285-304.
[32]Feng Y,Ralls MW,Xiao W,et al. Loss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction[J].?Ann N Y Acad Sci,2012,1258:71-77.
[33]Abada A,Elazar Z. Getting ready for building:signaling and autophagosome biogenesis[J].?EMBO Rep,2014,15(8):839-852.
[34]龚睿,薛迎昌,徐颢,等. 外源性硫化氢对家兔心肺复苏后肠黏膜屏障的影响[J]. 中华危重病急救医学,2018,30(12):1178-1183.
[35] Wu Y,Tang L,Wang B,et al. The role of autophagy in maintaining intestinal mucosal barrier[J]?J Cell Physiol,2019,234(11):19406-19419.
[36]Shakeri A,Cicero AFG,Panahi Y,et al. Curcumin:a naturally occurring autophagy modulator[J]. J Cell Physiol,2019,234(5):5643-5654.
[37]Li X,Lemaitre B. Autophagy as a gatekeeper of intestinal homeostasis[J]. Dev Cell,2021,56(1):5-6.
[38]陈辰,金盼盼,孙建刚,等. 大承气汤对心脏骤停后综合征胃肠功能恢复的影响[J]. 中国中医急症,2013,22(10):1738-1740.
[39]程阔菊,彭雷,朱丹,等. 柴胡疏肝散对胃肠功能紊乱大鼠模型胃肠道Cajal间质细胞凋亡的影响[J]. 西部中医药,2020,33(1):21-24.
[40]常瑞明,常建星,江志鹏,等. 乌司他丁对心肺复苏后大鼠肠屏障的保护作用[J]. 中华急诊医学杂志,2015,24(11):1234-1238.

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更新日期/Last Update: 2022-04-20