[1]戴越 周帆 穆军升.外源性电刺激诱导干细胞心肌向分化的研究进展[J].心血管病学进展,2022,(4):289-292，321.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.001]
　DAI Yue,ZHOU Fan,MU Junsheng.The Use of Electrical Stimulation to Induce Cardiac Differentiation of?tem Cells for the Treatment of Myocardial Infarction[J].Advances in Cardiovascular Diseases,2022,(4):289-292，321.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.001]
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外源性电刺激诱导干细胞心肌向分化的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年4期
页码:
289-292，321
栏目:
综述
出版日期:
2022-04-25

文章信息/Info

Title:
The Use of Electrical Stimulation to Induce Cardiac Differentiation of?tem Cells for the Treatment of Myocardial Infarction
作者:
戴越1 周帆2 穆军升1
(1.首都医科大学附属北京安贞医院心脏外科 北京市心肺血管疾病研究所,北京 100029 ;2.解放军总医院第三医学中心超声科,北京 100039 )
Author(s):
DAI Yue 1; ZHOU Fan2; MU Junsheng1
(1.Department of Cardiac Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029, China;2.Department of Ultrasound,The Third Medical Center of PLA General Hospital,Beijing 100039,China)
关键词:
电刺激; 干细胞; 心肌向分化; 心肌梗死
Keywords:
Electrical stimulation; Stem cells; Cardiac differentiation; Myocardial infarction
DOI:
10.16806/j.cnki.issn.1004-3934.2022.04.001
摘要:
心肌梗死引起的缺血性心脏疾病是影响人类健康的重要问题。基于干细胞的心肌梗死治疗前景广阔，然而干细胞经定向诱导分化形成的心肌细胞具有分化率和成熟度低的特点，移植到受损心肌处可能会增加心律失常的风险。相关研究表明，施加电刺激可显著促进干细胞的心肌向分化。现综述不同电刺激参数对不同干细胞类型的影响及其中可能涉及的相关机制。
Abstract:
Ischemic heart disease resulting from a myocardial infarction,is a major health issue. Stem cell therapies may play an important role in this field. However,cardiomyocytes induced from stem cells are characterized by low rates of differentiation and immaturity. After transplantation into the damaged heart,they may even increase the risk of arrhythmias. Studies have demonstrated that electrical stimulation can promote the cardiac differentiation of stem cells. This review summarizes the latest research on the effects of applying different electrical stimulation parameters to different types of stem cells and the related mechanisms that may be involved.

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更新日期/Last Update: 2022-05-13