[1]吉蓉 寿锡凌.秋水仙碱在冠状动脉粥样硬化性心脏病防治中的研究进展与争议[J].心血管病学进展,2022,(1):60-63.[doi:10.16806/j.cnki.issn.1004-3934.2022.01.016]
 JI Rong,SHOU Xiling.Research Progress and Controversy of Colchicine in Prevention and Treatment of Coronary Atherosclerotic Heart Disease[J].Advances in Cardiovascular Diseases,2022,(1):60-63.[doi:10.16806/j.cnki.issn.1004-3934.2022.01.016]
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秋水仙碱在冠状动脉粥样硬化性心脏病防治中的研究进展与争议()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年1期
页码:
60-63
栏目:
出版日期:
2022-01-25

文章信息/Info

Title:
Research Progress and Controversy of Colchicine in Prevention and Treatment of Coronary Atherosclerotic Heart Disease
作者:
吉蓉1 寿锡凌2
(1.西安医学院,陕西 西安 710068;2.陕西省人民医院心血管内科,陕西 西安710068)
Author(s):
JI Rong1SHOU Xiling2
(1.Xian Medical University, Xi’an 710068,Shaanxi,China; 2.Department of Cardiology,Shaanxi Provincial People’s Hospital, Xi’an 710068,Shaanxi,China)
关键词:
炎症冠状动脉粥样硬化性心脏病秋水仙碱
Keywords:
InflammationCoronary atherosclerotic heart diseaseColchicine
DOI:
10.16806/j.cnki.issn.1004-3934.2022.01.016
摘要:
既往大量研究表明炎症在冠状动脉粥样硬化性心脏病(冠心病)的发生和发展中扮演了重要角色,抗炎治疗一直是冠心病研究领域的热点。近年几项大型临床研究发现秋水仙碱可预防冠心病患者不良心血管事件的发生,改善冠心病患者的预后,但同时秋水仙碱在临床应用中也存在诸多争议。现就秋水仙碱在冠心病防治中的最新研究进展及存在的争议做一综述。
Abstract:
A large number of previous studies have shown that inflammation plays an important role in the occurrence and development of coronary atherosclerotic heart disease(CHD),and anti-inflammatory therapy has always been a hot spot in the field of CHD. In recent years,several large-scale clinical studies have found that colchicine can prevent adverse cardiovascular events in patients with CHD and improve the prognosis of patients with CHD. However,there are also many controversies in the clinical application of colchicine. This article reviews the latest research progress and existing controversies of colchicine in the prevention and treatment of CHD.

参考文献/References:

[1] Ajala ON,Everett BM. Targeting inflammation to reduce residual cardiovascular risk[J]. Curr Atheroscler Rep,2020,22(11):66.
[2] Olsen AM,Fosb?l EL,Lindhardsen J,et al. Long-term cardiovascular risk of nonsteroidal anti-inflammatory drug use according to time passed after first-time myocardial infarction:a nationwide cohort study[J]. Circulation,2012,126(16):1955-1963.
[3] Vogel RA,Forrester JS. Cooling off hot hearts:a specific therapy for vulnerable plaque[J]. J Am Coll Cardiol,2013,61(4):411-412.
[4] Ridker PM,Everett BM,Pradhan A,et al. Low-dose methotrexate for the prevention of atherosclerotic events[J]. N Engl J Med,2019,380(8):752-762.
[5] Klingenberg R,Lüscher TF. CANTOS:a seductive song with several verses[J]. Eur Heart J,2018,39(38):3508-3510.
[6] van Hout GP,Bosch L,Ellenbroek GH,et al. The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction[J]. Eur Heart J,2017,38(11):828-836.
[7] Parisi V,Petraglia L,D’Esposito V,et al. Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue[J]. Int J Cardiol,2019,274:326-330.
[8] Opstal T,Hoogeveen RM,Fiolet A,et al. Colchicine attenuates inflammation beyond the inflammasome in chronic coronary artery disease:A LoDoCo2 Proteomic Substudy[J]. Circulation,2020,142(20):1996-1998.
[9] Martínez GJ,Celermajer DS,Patel S. The NLRP3 inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation[J]. Atherosclerosis,2018,269:262-271.
[10] Shah B,Allen N,Harchandani B,et al. Effect of colchicine on platelet-platelet and platelet-leukocyte interactions:a pilot study in healthy subjects[J]. Inflammation,2016,39(1):182-189.
[11] Barraclough JY,Joglekar MV,Januszewski AS,et al. A microRNA signature in acute coronary syndrome patients and modulation by colchicine[J]. J Cardiovasc Pharmacol Ther,2020,25(5):444-455.
[12] Jong WM,Leemans JC,Weber NC,et al. Nlrp3 plays no role in acute cardiac infarction due to low cardiac expression[J]. Int J Cardiol,2014,177(1):41-43.
[13] He Y,Zeng MY,Yang D,et al. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux[J]. Nature,2016,530(7590):354-357.
[14] Solomon DH,Liu CC,Kuo IH,et al. Effects of colchicine on risk of cardiovascular events and mortality among patients with gout:a cohort study using electronic medical records linked with Medicare claims[J]. Ann Rheum Dis,2016,75(9):1674-1679.
[15] Fiolet A,Silvis M,Opstal T,et al. Short-term effect of low-dose colchicine on inflammatory biomarkers,lipids,blood count and renal function in chronic coronary artery disease and elevated high-sensitivity C-reactive protein[J]. PLoS One,2020,15(8):e0237665.
[16] Nidorf M,Thompson PL. Effect of colchicine(0.5 mg twice daily) on high-sensitivity C-reactive protein independent of aspirin and atorvastatin in patients with stable coronary artery disease[J]. Am J Cardiol,2007,99(6):805-807.
[17] Nidorf SM,Eikelboom JW,Budgeon CA,et al. Low-dose colchicine for secondary prevention of cardiovascular disease[J]. J Am Coll Cardiol,2013,61(4):404-410.
[18] Nidorf SM,Fiolet A,Mosterd A,et al. Colchicine in patients with chronic coronary disease[J]. N Engl J Med,2020,383(19):1838-1847.
[19] Xia M,Yang X,Qian C. Meta-analysis evaluating the utility of colchicine in secondary prevention of coronary artery disease[J]. Am J Cardiol,2021,140:33-38.
[20] Tien YY,Huang HK,Shih MC,et al. Drug repurposing? Cardiovascular effect of colchicine on patients with coronary artery disease:a systematic review and meta-analysis[J]. J Cardiol,2021,77(6):576-582.
[21] Mani P,Puri R,Schwartz GG,et al. Association of initial and serial C-reactive protein levels with adverse cardiovascular events and death after acute coronary syndrome:a secondary analysis of the VISTA-16 trial[J]. JAMA Cardiol,2019,4(4):314-320.
[22] Vaidya K,Arnott C,Martínez GJ,et al. Colchicine therapy and plaque stabilization in patients with acute?coronary syndrome:a CT coronary angiography study[J]. JACC Cardiovasc Imaging,2018,11(2 Pt 2):305-316.
[23] Deftereos S,Giannopoulos G,Angelidis C,et al. Anti-inflammatory treatment with colchicine in acute myocardial infarction:a pilot study[J]. Circulation,2015,132(15):1395-1403.
[24] Tardif JC,Kouz S,Waters DD,et al. Efficacy and safety of low-dose colchicine after myocardial infarction[J]. N Engl J Med,2019,381(26):2497-2505.
[25] Akodad M,Fauconnier J,Sicard P,et al. Interest of colchicine in the treatment of acute myocardial infarct responsible for heart failure in a mouse model[J]. Int J Cardiol,2017,240:347-353.
[26] Fujisue K,Sugamura K,Kurokawa H,et al. Colchicine improves survival,left ventricular remodeling,and chronic cardiac function after acute myocardial infarction[J]. Circ J,2017,81(8):1174-1182.
[27] Kajikawa M,Higashi Y,Tomiyama H,et al. Effect of short-term colchicine treatment on endothelial function in patients with coronary artery disease[J]. Int J Cardiol,2019,281:35-39.
[28] Guedeney P,Claessen BE,Kalkman DN,et al. Residual inflammatory risk in patients?with low LDL cholesterol levels?undergoing percutaneous coronary?intervention[J]. J Am Coll Cardiol,2019,73(19):2401-2409.
[29] Martínez GJ,Robertson S,Barraclough J,et al. Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome[J]. J Am Heart Assoc,2015,4(8):e002128.
[30] Shah B,Pillinger M,Zhong H,et al. Effects of acute colchicine administration prior to percutaneous coronary intervention:COLCHICINE-PCI Randomized Trial[J]. Circ Cardiovasc Interv,2020,13(4):e008717.
[31] O’Keefe JH Jr,McCallister BD,Bateman TM,et al. Ineffectiveness of colchicine for the prevention of restenosis after coronary angioplasty[J]. J Am Coll Cardiol,1992,19(7):1597-1600.
[32] Deftereos S,Giannopoulos G,Raisakis K,et al. Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients[J]. J Am Coll Cardiol,2013,61(16):1679-1685.
[33] Tong DC,Quinn S,Nasis A,et al. Colchicine in patients with acute coronary syndrome:The Australian COPS Randomized Clinical Trial[J]. Circulation,2020,142(20):1890-1900.
[34] Stewart S,Yang K,Atkins K,et al. Adverse events during oral colchicine use:a systematic review and meta-analysis of randomised controlled trials[J]. Arthritis Res Ther,2020,22(1):28.
[35] Cirillo P,Taglialatela V,Pellegrino G,et al. Effects of colchicine on platelet aggregation in patients on dual antiplatelet therapy with aspirin and clopidogrel[J]. J Thromb Thrombolysis,2020,50(2):468-472.
[36] Sag E,Bayindir Y,Adiguzel A,et al. Colchicine and leukopenia:clinical implications[J]. J Pediatr,2020,224:166-170.e1.
[37] Baker SK,Goodwin S,Sur M,et al. Cytoskeletal myotoxicity from simvastatin and colchicine[J]. Muscle Nerve,2004,30(6):799-802.
[38] Huang C,Cen C,Wang C,et al. Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia[J]. Lipids Health Dis,2014,13:67.
[39] Hennessy T,Soh L,Bowman M,et al. The Low Dose Colchicine after Myocardial Infarction(LoDoCo-MI) study:a pilot randomized placebo controlled trial of colchicine following acute myocardial infarction[J]. Am Heart J,2019,215:62-69.
[40] Hemkens LG,Ewald H,Gloy VL,et al. Colchicine for prevention of cardiovascular events[J]. Cochrane Database Syst Rev,2016,2016(1):CD011047.
[41] McKnight AH,Katzenberger DR,Britnell SR. Colchicine in acute coronary syndrome:a systematic review[J]. Ann Pharmacother,2021,55(2):187-197.

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更新日期/Last Update: 2022-02-18