[1]袁明明 赖松青 张泽宇 吴起才.铁死亡在脓毒症心脏功能损伤中的研究进展[J].心血管病学进展,2022,(1):26-29.[doi:10.16806/j.cnki.issn.1004-3934.2022.01.007]
 YUAN mingmingLAI SongqingZHANG ZeyuWU Qicai.Ferroptosis in Cardiac Function Impairment in Sepsis[J].Advances in Cardiovascular Diseases,2022,(1):26-29.[doi:10.16806/j.cnki.issn.1004-3934.2022.01.007]
点击复制

铁死亡在脓毒症心脏功能损伤中的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年1期
页码:
26-29
栏目:
出版日期:
2022-01-25

文章信息/Info

Title:
Ferroptosis in Cardiac Function Impairment in Sepsis
作者:
袁明明 赖松青 张泽宇 吴起才
(南昌大学第一附属医院 心脏大血管疾病研究所,江西 南昌 330006)
Author(s):
YUAN mingmingLAI SongqingZHANG ZeyuWU Qicai
(The First Affiliated Hospital of Nanchang University,Institute of Cardiovascular Diseases,Nanchang 330006,Jiangxi,China)
关键词:
脓毒症脓毒性心肌病铁死亡
Keywords:
SepsisSeptic cardiomyopathyFerroptosis
DOI:
10.16806/j.cnki.issn.1004-3934.2022.01.007
摘要:
脓毒症是急危重症患者主要死亡原因之一。脓毒性心肌病是脓毒症的严重并发症,并与脓毒症高死亡率直接相关。铁死亡是最近才发现的一种调节性细胞死亡形式。迄今为止,铁死亡已被证明参与了许多疾病的病理生理机制,如阿尔茨海默病、癌症、帕金森病和肾脏退化。目前有相关研究报道铁死亡可能参与了脓毒性心肌病的发生。现总结铁死亡在脓毒性心肌病中心肌细胞死亡的相关证据,为脓毒性心肌病进一步的研究和治疗提供新思路。
Abstract:
Sepsis is one of the common causes of death in acute and critical patients. Septic cardiomyopathy is a serious complication of sepsis and is directly related to the high mortality rate of sepsis. Ferroptosis is a form of regulatory cell death that has only recently been discovered. To date,ferroptosis has been shown to be involved in the pathophysiological mechanisms of many diseases,such as Alzheimer’s disease,cancer,Parkinson disease,and kidney degeneration. At present,related studies have reported that ferroptosis may be involved in the occurrence of septic cardiomyopathy. This article will summarize the evidence of ferroptosis in myocardial cell death in septic cardiomyopathy and provide new ideas for further research and treatment of septic cardiomyopathy

参考文献/References:



[1] Cecconi M,Evans L,Levy M,et al. Sepsis and septic shock[J]. Lancet,2018,392(10141):75-87.

[2] Hollenberg SM,Singer M. Pathophysiology of sepsis-induced cardiomyopathy[J]. Nat Rev Cardiol,2021,18(6):424-434.

[3] Liu YC,Yu MM,Shou ST,et al. Sepsis-induced cardiomyopathy:mechanisms and treatments[J]. Front Immunol,2017,8:1021.

[4] Lee WJ,Chen YL,Chu YW,et al. Comparison of glutathione peroxidase-3 protein expression and enzyme bioactivity in normal subjects and patients with sepsis[J]. Clin Chim Acta,2019,489:177-182.

[5] Tahrir FG,Langford D,Amini S,et al. Mitochondrial quality control in cardiac cells:mechanisms and role in cardiac cell injury and disease[J]. J Cell Physiol,2019,234(6):8122-8133.

[6] Nolfi-Donegan D,Braganza A,Shiva S. Mitochondrial electron transport chain:oxidative phosphorylation,oxidant production,and methods of measurement[J]. Redox Biol,2020,37:101674.

[7] Guo J,Hong Y,Wang Z,et al. Analysis of the incidence of euthyroid sick syndrome in comprehensive intensive care units and related risk factors[J]. Front Endocrinol(Lausanne),2021,12:656641.

[8] Lin Y,Xu Y,Zhang Z. Sepsis-induced myocardial dysfunction(SIMD):the pathophysiological mechanisms and therapeutic strategies targeting mitochondria[J]. Inflammation,2020,43(4):1184-1200.

[9] Wu Y,Yao YM,Lu ZQ. Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure[J]. J Mol Med(Berl),2019,97(4):451-462.

[10] Tang D,Kang R,Berghe TV,et al. The molecular machinery of regulated cell death[J]. Cell Res,2019,29(5):347-364.

[11] Dixon SJ,Lemberg KM,Lamprecht MR,et al. Ferroptosis:an iron-dependent form of nonapoptotic cell death[J]. Cell,2012,149(5):1060-1072.

[12] Imai H,Matsuoka M,Kumagai T,et al. Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis[J]. Curr Top Microbiol Immunol,2017,403:143-170.

[13] Stockwell BR,Friedmann Angeli JP,Bayir H,et al. Ferroptosis:a regulated cell death nexus linking metabolism,redox biology,and disease[J]. Cell,2017,171(2):273-285.

[14] Mussbacher M,Salzmann M,Brostjan C,et al. Cell type-specific roles of NF-κB linking inflammation and thrombosis[J]. Front Immunol,2019,10:85.

[15] Mittler R. ROS are good[J]. Trends Plant Sci,2017,22(1):11-19.

[16] Lundgren CAK,Sj?strand D,Biner O,et al. Scavenging of superoxide by a membrane-bound superoxide oxidase[J]. Nat Chem Biol,2018,14(8):788-793.

[17] Lei P,Bai T,Sun Y. Mechanisms of ferroptosis and relations with regulated cell death:a review[J]. Front Physiol,2019,10:139.

[18] Ingold I,Berndt C,Schmitt S,et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis[J]. Cell,2018,172(3):409-422.e21.

[19] Wei S,Bi J,Yang L,et al. Serum irisin levels are decreased in patients with sepsis,and exogenous irisin suppresses ferroptosis in the liver of septic mice[J]. Clin Transl Med,2020,10(5):e173.

[20] Beesley SJ,Weber G,Sarge T,et al. Septic cardiomyopathy[J]. Crit Care Med,2018,46(4):625-634.

[21] Martitz J,Becker NP,Renko K,et al. Gene-specific regulation of hepatic selenoprotein expression by interleukin-6[J]. Metallomics,2015,7(11):1515-1521.

[22] Avery JC,Hoffmann PR. Selenium,selenoproteins,and immunity[J]. Nutrients,2018,10(9) :1203.

[23] Forceville X,van Antwerpen P,Preiser JC. Selenocompounds and sepsis:redox bypass hypothesis for early diagnosis and treatment:part A—Early acute phase of sepsis:an extraordinary redox situation(leukocyte/endothelium interaction leading to endothelial damage)[J]. Antioxid Redox Signal,2021,35(2):113-138.

[24] Seibt TM,Proneth B,Conrad M. Role of GPX4 in ferroptosis and its pharmacological implication[J]. Free Radic Biol Med,2019,133:144-152.

[25] Zhou B,Zhang JY,Liu XS,et al. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis[J]. Cell Res,2018,28(12):1171-1185.

[26] Sae-Khow K,Charoensappakit A,Visitchanakun P,et al. Pathogen-associated molecules from gut translocation enhance severity of cecal ligation and puncture sepsis in iron-overload β-thalassemia mice[J]. J Inflamm Res,2020,13:719-735.

[27] Wang C,Yuan W,Hu A,et al. Dexmedetomidine alleviated sepsis-induced myocardial ferroptosis and septic heart injury[J]. Mol Med Rep,2020,22(1):175-184.

[28] Fang X,Cai Z,Wang H,et al. Loss of cardiac ferritin H facilitates cardiomyopathy via Slc7a11-mediated ferroptosis[J]. Circ Res,2020,127(4):486-501.

[29] Ravingerová T,Kindernay L,Barteková M,et al. The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection[J]. Int J Mol Sci,2020,21(21):7889.

[30] He YJ,Liu XY,Xing L,et al. Fenton reaction-independent ferroptosis therapy via glutathione and iron redox couple sequentially triggered lipid peroxide generator[J]. Biomaterials,2020,241:119911.

[31] Li Y,Zhang X,Zhang C,et al. Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates[J]. J Physiol,2018,596(7):1137-1151.

[32] Ward DM,Cloonan SM. Mitochondrial iron in human health and disease[J]. Annu Rev Physiol,2019,81:453-482.

[33] Khamseekaew J,Kumfu S,Palee S,et al. Effects of the iron chelator deferiprone and the T-type calcium channel blocker efonidipine on cardiac function and Ca2+ regulation in iron-overloaded thalassemic mice[J]. Cell Calcium,2018,72:18-25.

[34] Fang X,Wang H,Han D,et al. Ferroptosis as a target for protection against cardiomyopathy[J]. Proc Natl Acad Sci U S A,2019,116(7):2672-2680.

[35] Liu B,Zhao C,Li H,et al. Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis[J]. Biochem Biophys Res Commun,2018,497(1):233-240.

[36] Li N,Wang W,Zhou H,et al. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury[J]. Free Radic Biol Med,2020,160:303-318.

相似文献/References:

[1]宋元秀 崔鸣.线粒体动力学异常与相关心血管疾病[J].心血管病学进展,2021,(2):162.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.017]
 SONG Yuanxiu,CUI Ming.Correlation Between Mitochondrial Dynamics and Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2021,(1):162.[doi:10.16806/j.cnki.issn.1004-3934.2020.02.017]
[2]王平 项涛 罗丽 孙玉芳 陈小红 张济梅 黄永平 张碧花.脓毒症与心力衰竭:两样本孟德尔随机化研究[J].心血管病学进展,2022,(8):759.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.022]
 WANG Ping,XIANG Tao,LUO Li,et al.Sepsis and Heart Failure: A Two-Sample Mendelian Randomization Study[J].Advances in Cardiovascular Diseases,2022,(1):759.[doi:10.16806/j.cnki.issn.1004-3934.2022.08.022]
[3]刘江文 王凤媛 李彬 杨双 吴浩亮 唐艳红 王晞 黄从新.鞣花酸灌胃对脂多糖诱导的脓毒症心功能不全的影响[J].心血管病学进展,2023,(2):181.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.019]
 LIU JiangwenWANG FengyuanLI BinYANG ShuangWU HaoliangTANG YanhongWANG XiHUANG Congxin.Effects of Ellagic Acid intragastric Administration on Cardiac Insufficiency Induced by Lipopolysaccharide Sepsis[J].Advances in Cardiovascular Diseases,2023,(1):181.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.019]

更新日期/Last Update: 2022-02-17