[1]段安琪 罗勤 赵智慧 赵青 柳志红.体外膜肺氧合支持下肝素诱导的血小板减少症研究进展[J].心血管病学进展,2021,(12):1157-1160.[doi:10.16806/j.cnki.issn.1004-3934.2021.12.001]
 DUAN Anqi,LUO Qin,ZHAO Zhihui,et al.Heparin-Induced Thrombocytopenia in Patients Receiving Extracorporeal Membrane Oxygenation[J].Advances in Cardiovascular Diseases,2021,(12):1157-1160.[doi:10.16806/j.cnki.issn.1004-3934.2021.12.001]
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体外膜肺氧合支持下肝素诱导的血小板减少症研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年12期
页码:
1157-1160
栏目:
综述
出版日期:
2021-12-25

文章信息/Info

Title:
Heparin-Induced Thrombocytopenia in Patients Receiving Extracorporeal Membrane Oxygenation
作者:
段安琪1 罗勤2 赵智慧2 赵青2 柳志红2
(1.北京协和医学院,北京 100730;2.中国医学科学院 国家心血管病中心 阜外医院心内科,北京 100037)
Author(s):
DUAN Anqi1LUO Qin2ZHAO Zhihui2ZHAO Qing2LIU Zhihong2
(1.Peking Union Medical CollegeBeijing 100730China2.Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical ScienceBeijing 100037China)
关键词:
体外膜肺氧合肝素血小板减少症血栓形成
Keywords:
Extracorporeal membrane oxygenationHeparinThrombocytopeniaThrombosis
DOI:
10.16806/j.cnki.issn.1004-3934.2021.12.001
摘要:
肝素诱导的血小板减少症是在少数接受肝素治疗的患者中出现的一种严重不良反应。近年来,越来越多的研究证据提示接受体外膜肺氧合治疗的患者发生肝素诱导的血小板减少症的风险可能高于一般人群,而相关的血栓形成可能会对患者的预后带来不利影响。现就体外膜肺氧合支持下肝素诱导的血小板减少症的流行病学、危险因素、诊断方法和治疗策略等方面的相关研究进展做一综述,为临床诊疗提供参考。
Abstract:
Heparin-induced thrombocytopenia is a serious adverse event in patients receiving heparin treatment. In recent years,accumulating evidence suggests that patients receiving extracorporeal membrane oxygenation treatment are at a higher risk of heparin-induced thrombocytopenia than the general population and heparin-induced thrombocytopenia and thrombosis may have adverse effects on the prognosis. This article reviews the research progress of heparin-induced thrombocytopenia under extracorporeal membrane oxygenation support in epidemiology,risk factors,diagnostic methods,and treatment strategies

参考文献/References:

[1] Murphy DA,Hockings LE,Andrews RK,et al. Extracorporeal membrane oxygenation-hemostatic complications[J]. Transfus Med Rev,2015,29(2):90-101.
[2] Chlebowski MM,Baltagi S,Carlson M,et al. Clinical controversies in anticoagulation monitoring and antithrombin supplementation for ECMO[J]. Crit Care,2020,24(1):19.
[3] Extracorporeal life support organization.ELSO Anticoagulation Guideline[EB/OL].(2015-05-01)[2021-07-05].https://www.elso.org/Portals/0/Files/elsoanticoagulationguideline8-2014-table-contents.pdf.
[4] Salter BS,Weiner MM,Trinh MA,et al. Heparin-induced thrombocytopenia: a comprehensive clinical review[J]. J Am Coll Cardiol,2016,67(21):2519-2532.
[5] Sokolovic M,Pratt AK,Vukicevic V,et al. Platelet count trends and prevalence of heparin-induced thrombocytopenia in a cohort of extracorporeal membrane oxygenator patients[J]. Crit Care Med,2016,44(11):e1031-e1037.
[6] Kimmoun A,Oulehri W,Sonneville R,et al. Prevalence and outcome of heparin-induced thrombocytopenia diagnosed under veno-arterial extracorporeal membrane oxygenation: a retrospective nationwide study[J]. Intensive Care Med,2018,44(9):1460-1469.
[7] Arachchillage DRJ,Laffan M,Khanna S,et al. Frequency of thrombocytopenia and heparin-induced thrombocytopenia in patients receiving extracorporeal membrane oxygenation compared with cardiopulmonary bypass and the limited sensitivity of pretest probability score[J]. Crit Care Med,2020,48(5):e371-e379.
[8] Pollak U. Heparin-induced thrombocytopenia complicating extracorporeal membrane oxygenation support:review of the literature and alternative anticoagulants[J]. J Thromb Haemost,2019,17(10):1608-1622.
[9] Greinacher A,Alban S,Omer-Adam MA,et al. Heparin-induced thrombocytopenia: a stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin,low-molecular-weight heparin,and fondaparinux in different clinical settings[J]. Thromb Res,2008,122(2):211-220.
[10] Koster A,Loebe M,Sodian R,et al. Heparin antibodies and thromboembolism in heparin-coated and noncoated ventricular assist devices[J]. J Thorac Cardiovasc Surg, 2001,121(2):331-335.
[11] Ranucci M,Balduini A,Ditta A,et al. A systematic review of biocompatible cardiopulmonary bypass circuits and clinical outcome[J]. Ann Thorac Surg,2009,87(4):1311-1319.
[12] Pabst D,Boone JB,Soleimani B,et al. Heparin-induced thrombocytopenia in patients on extracorporeal membrane oxygenation and the role of a heparin-bonded circuit[J]. Perfusion,2019,34(7):584-589.
[13] 许俊堂李为民门剑龙. 肝素诱导的血小板减少症中国专家共识(2017). 中华医学杂志2018,98(6):408-417.
[14] Kataria V,Moore L,Harrison S,et al. Evaluation of serotonin release assay and enzyme-linked immunosorbent assay optical density thresholds for heparin-induced thrombocytopenia in patients on extracorporeal membrane oxygenation[J]. Crit Care Med,2020,48(2):e82-e86.
[15] Renou A,Neuschwander A,Kimmoun A,et al. Modified 4T score for heparin-induced thrombocytopenia diagnosis in VA-ECMO patients[J]. Intensive Care Med,2020,46(7):1481-1483.
[16] Lillo-Le Lou?t A,Boutouyrie P,Alhenc-Gelas M,et al. Diagnostic score for heparin-induced thrombocytopenia after cardiopulmonary bypass[J]. J Thromb Haemost,2004,2(11):1882-1888.
[17] Greinacher A. Heparin-induced thrombocytopenia[J]. N Engl J Med,2015,373(19):1883-1884.
[18] Tomasko J,Prasad SM,Dell DO,et al. Therapeutic anticoagulation-free extracorporeal membrane oxygenation as a bridge to lung transplantation[J]. J Heart Lung Transplant,2016,35(7):947-948.
[19] Fina D,Matteucci M,Jiritano F,et al. Extracorporeal membrane oxygenation without systemic anticoagulation: a case-series in challenging conditions[J]. J Thorac Dis,2020;12(5):2113-9.
[20] Yeo HJ,Kim DH,Jeon D,et al. Low-dose heparin during extracorporeal membrane oxygenation treatment in adults[J]. Intensive Care Med. 2015;41(11):2020-1.
[21] Wood KL,Ayers B,Gosev I,et al. Venoarterial-extracorpal membrane oxygenation without routine systemic anticoagulation decreases adverse events[J]. Ann Thorac Surg,2020,109(5):1458-1466.
[22] Krueger K,Schmutz A,Zieger B,et al. Venovenous extracorporeal membrane oxygenation with prophylactic subcutaneous anticoagulation only: an observational study in more than 60 patients[J]. Artif Organs,2017,41(2):186-192.
[23] Rougé A,Pelen F,Durand M,et al. Argatroban for an alternative anticoagulant in HIT during ECMO[J]. J Intensive Care,2017,5:39.
[24] Fisser C,Winkler M,Malfertheiner MV,et al. Argatroban versus heparin in patients without heparin-induced thrombocytopenia during venovenous extracorporeal membrane oxygenation: a propensity-score matched study[J]. Crit Care,2021,25(1):160.
[25] Kim YS,Lee H,Yang JH,et al. Use of argatroban for extracorporeal life support in patients with nonheparin-induced thrombocytopenia: analysis of 10 consecutive patients[J]. Medicine (Baltimore),2018,97(47):e13235.
[26] Zhong H,Zhu ML,Yu YT,et al. Management of bivalirudin anticoagulation therapy for extracorporeal membrane oxygenation in heparin-induced thrombocytopenia: a case report and a systematic review[J]. Front Pharmacol, 2020,11:565013.
[27] Dager WE,Gosselin RC,Yoshikawa R,et al. Lepirudin in heparin-induced thrombocytopenia and extracorporeal membranous oxygenation[J]. Ann Pharmacother,2004,38(4):598-601.
[28] Parlar AI,Sayar U,Cevirme D,et al. Successful use of fondaparinux in a patient with heparin-induced thrombocytopenia while on extracorporeal membrane oxygenation after mitral valve redo surgery[J]. Int J Artif Organs,2014,37(4):344-347.

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备注/Memo

备注/Memo:
收稿日期:2021-07-05
基金项目:北京市自然科学基金(7202168);中国医学科学院临床与转化医学研究基金(2020-I2M-C&T-B-055)
通信作者:柳志红,E-mail: liuzhihong_fw@263.com
更新日期/Last Update: 2022-01-07