[1]董天慧 周力 陈晖.焦虑与冠状动脉痉挛：不容忽视的风险[J].心血管病学进展,2021,(12):1069-1073.[doi:10.16806/j.cnki.issn.1004-3934.2021.12.004]
　DONG Tianhui,ZHOU Li,Chen Hui.Anxiety and Coronary Artery Spasm:a Risk Not To Be Ignored[J].Advances in Cardiovascular Diseases,2021,(12):1069-1073.[doi:10.16806/j.cnki.issn.1004-3934.2021.12.004]
点击复制

焦虑与冠状动脉痉挛：不容忽视的风险()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年12期
页码:
1069-1073
栏目:
综述
出版日期:
2021-12-25

文章信息/Info

Title:
Anxiety and Coronary Artery Spasm:a Risk Not To Be Ignored
作者:
董天慧 周力 陈晖
(首都医科大学附属北京友谊医院心内科,北京 100050)
Author(s):
DONG Tianhui; ZHOU Li; Chen Hui
(Beijing Friendship Hospital,Capital Medical?niversity,Beijing 100050,China)
关键词:
焦虑; 心理精神疾病; 冠状动脉痉挛; 变异型心绞痛
Keywords:
Anxiety; Psychosocial disease; Coronary artery spasm; Variant angina pectoris arial;  helvetica;  sans-serif; ">?/span>; 
DOI:
10.16806/j.cnki.issn.1004-3934.2021.12.004
摘要:
焦虑作为现代社会的一种心理精神疾病，已在人群中普遍存在。焦虑不仅会影响患者的生活质量，还会增加冠状动脉粥样硬化性心脏病（冠心病）的发病风险，需引起临床医生的关注。由冠状动脉痉挛（CAS）引起的变异型心绞痛临床上也并不少见。目前已有多项研究发现焦虑与CAS之间存在相互作用。抗焦虑及抗CAS治疗分别有效改善患者焦虑症状及减少CAS发作。因此现就焦虑与CAS之间的影响、作用机制以及治疗方面进行综述。
Abstract:
Anxiety,as a kind of psychosocial disease in modern society,has been ubiquitous among people. Anxiety not only affects patients’ quality of life,but also increases the risk of coronary atherosclerotic heart disease (coronary heart disease),which needs to be paid attention to by clinicians. Variant angina pectoris caused by coronary artery spasm is not uncommon clinically. At present,a number of studies have found the interaction between anxiety and coronary artery spasm. Anti-anxiety and anti-coronary artery spasm therapy can effectively improve the anxiety and reduce the onset of coronary artery spasm. Therefore,this paper reviews the relationship,mechanism of action and treatment between anxiety and coronary artery spasm.

参考文献/References:

[1]van Dijk MR,Utens EM,Dulfer K,et al. Depression and anxiety symptoms as predictors of mortality in PCI patients at 10 years of follow-up[J]. Eur J Prev Cardiol,2016,23(5):552-558.
[2]中华医学会神经病学分会,中华医学会神经病学分会睡眠障碍学组,中华医学会神经病学分会神经心理与行为神经病学学组. 中国成人失眠伴抑郁焦虑诊治专家共识[J]. 中华神经科杂志,2020,53(8):564-574.
[3]DeMartini J,Patel G,Fancher TL. Generalized anxiety disorder[J]. Ann Intern Med,2019,170(7):ITC49-ITC64.
[4]Carpenter JK,Andrews LA,Witcraft SM,et al. Cognitive behavioral therapy for anxiety and related disorders:a meta-analysis of randomized placebo-controlled trials[J]. Depress Anxiety,2018,35(6):502-514.
[5]汪凯,朱春燕,陈海波. 综合医院焦虑、抑郁与躯体化症状诊断治疗的专家共识[J]. 中华神经科杂志,2016,49(12):908-917.
[6]Roest AM,Martens EJ,de Jonge P,et al. Anxiety and risk of incident coronary heart disease:a meta-analysis[J]. J Am Coll Cardiol,2010,56(1):38-46.
[7]de Hert M,Detraux J,Vancampfort D. The intriguing relationship between coronary heart disease and mental disorders[J]. Dialogues Clin Neurosci,2018,20(1):31-40.
[8]Liu H,Tian Y,Liu Y,et al. Relationship between major depressive disorder,generalized anxiety disorder and coronary artery disease in the US general population[J]. J Psychosom Res,2019,119:8-13.
[9]Mesa-Vieira C,Grolimund J,von K?nel R,et al. Psychosocial risk factors in cardiac rehabilitation:time to screen beyond anxiety and depression[J]. Glob Heart,2021,16(1):16.
[10]Gulati R,Behfar A,Narula J,et al. Acute myocardial infarction in young individuals[J]. Mayo Clin Proc,2020,95(1):136-156.
[11]Matta A,Bouisset F,Lhermusier T,et al. Coronary artery spasm:new insights[J]. J Interv Cardiol,2020,2020:5894586.
[12]Yasue H,Mizuno Y,Harada E. Coronary artery spasm—Clinical features,pathogenesis and treatment[J]. Proc Jpn Acad Ser B Phys Biol Sci,2019,95(2):53-66.
[13]Itoh T,Mizuno Y,Harada E,et al. Coronary spasm is associated with chronic low-grade inflammation[J]. Circ J,2007,71(7):1074-1078.
[14]Yasue H,Horio Y,Nakamura N,et al. Induction of coronary artery spasm by acetylcholine in patients with variant angina:possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm[J]. Circulation,1986,74(5):955-963.
[15]Miyao Y,Kugiyama K,Kawano H,et al. Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina[J]. J Am Coll Cardiol,2000,36(2):432-437.
[16]Ohyama K,Matsumoto Y,Takanami K,et al. Coronary adventitial and perivascular adipose tissue inflammation in patients with vasospastic angina[J]. J Am Coll Cardiol,2018,71(4):414-425.
[17]Hung MY,Mao CT,Hung MJ,et al. Coronary artery spasm as related to anxiety and depression:a nationwide population-based study[J]. Psychosom Med,2019,81(3):237-245.
[18]Mehta PK,Thobani A,Vaccarino V. Coronary artery spasm,coronary reactivity,and their psychological context[J]. Psychosom Med,2019,81(3):233-236.
[19]霍燕飞. 焦虑抑郁状态与冠状动脉慢血流现象的相关性探讨[J]. 中西医结合心脑血管病杂志,2019,17(03):422-425.
[20]Elamragy AA,Abdelhalim AA,Arafa ME,et al. Anxiety and depression relationship with coronary slow flow[J]. PLoS One,2019,14(9):e0221918.
[21] Santos IS,Goulart AC,Brunoni AR,et al. Anxiety and depressive symptoms are associated with higher carotid intima-media thickness. Cross-sectional analysis from ELSA-Brasil baseline data[J]. Atherosclerosis,2015,240(2):529-534.
[22]王树娟,崔建国,齐洁等. 焦虑对老年高血压患者血压变异性、内皮素-1、一氧化氮的影响研究[J]. 中国全科医学,2019,22(34):4277-4282.
[23]Gimbrone MA Jr,García-Carde?a G. Endothelial cell dysfunction and the pathobiology of atherosclerosis[J]. Circ Res,2016,118(4):620-636.
[24]牟艳丽,李倩. 观察伴不同焦虑和（或）抑郁障碍冠心病患者以心率变异性（HRV）为代表的自主神经功能损害情况[J]. 中国医药指南,2019,17(30):118-119.
[25]Fu P,Gibson CJ,Mendes WB,et al. Anxiety,depressive symptoms,and cardiac autonomic function in perimenopausal and postmenopausal women with hot flashes:a brief report[J]. Menopause,2018,25(12):1470-1475.
[26]Sakata K,Yoshida H,Hoshino T,et al. Sympathetic nerve activity in the spasm-induced coronary artery region is associated with disease activity of vasospastic angina[J]. J Am Coll Cardiol,1996,28(2):460-464.
[27]Costello H,Gould RL,Abrol E,et al. Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder[J]. BMJ Open,2019,9(7):e027925.
[28]刘永政,郜琳,王倩. 焦虑抑郁障碍对女性冠心病患者血清CA125和TNF-α表达的影响[J]. 中国实验诊断学,2019,23(04):649-650.
[29]Morita S,Mizuno Y,Harada E,et al. Differences and interactions between risk factors for coronary spasm and atherosclerosis—Smoking,aging,inflammation,and blood pressure[J]. Intern Med,2014,53(23):2663-2670.
[30]de Heer EW,Palacios JE,Adèr HJ,et al. Chest pain,depression and anxiety in coronary heart disease:consequence or cause? A prospective clinical study in primary care[J]. J Psychosom Res,2020,129:109891.
[31]Gerrits MMJG,van Oppen P,van Marwijk HWJ,et al. Pain and the onset of depressive and anxiety disorders[J]. Pain,2014,155(1):53-59.
[32]Kremer M,Becker LJ,Barrot M,et al. How to study anxiety and depression in rodent models of chronic pain?[J]. Eur J Neurosci,2020,53(1):236-270.
[33]Lee C,Lee SC,Shin YS,et al. Severity,progress,and related factors of mood disorders in patients with coronary artery disease:a retrospective study[J]. Healthcare (Basel),2020,8(4):568.
[34]Reavell J,Hopkinson M,Clarkesmith D,et al. Effectiveness of cognitive behavioral therapy for depression and anxiety in patients with cardiovascular disease:a systematic review and meta-analysis[J]. Psychosom Med,2018,80(8):742-753.
[35]Mallorquí-Bagué N,Bulbena A,Pailhez G,et al. Mind-body interactions in anxiety and somatic symptoms[J]. Harv Rev Psychiatry,2016,24(1):53-60.
[36]Kwok JYY,Kwan JCY,Auyeung M,et al. Effects of mindfulness yoga vs stretching and resistance training exercises on anxiety and depression for people with Parkinson disease:a randomized clinical trial[J]. JAMA Neurol,2019,76(7):755-763.
[37]Chen TR,Huang HC,Hsu JH,et al. Pharmacological and psychological interventions for generalized anxiety disorder in adults:a network meta-analysis[J]. J Psychiatr Res,2019,118:73-83.
[38]郝瑞军,段俊芳,康慧敏. 药物联合认知行为疗法治疗广泛性焦虑障碍患者的疗效观察[J]. 中国药物与临床,2019,19(16):2811-2812.
[39]Rodríguez-Ma?ero M,Oloriz T,le Polain de Waroux JB,et al. Long-term prognosis of patients with life-threatening ventricular arrhythmias induced by coronary artery spasm[J]. Europace,2018,20(5):851-858.
[40]Hoge EA,Ivkovic A,Fricchione GL. Generalized anxiety disorder:diagnosis and treatment[J]. BMJ,2012,345:e7500.

相似文献/References:

[1]赵薇 陈芸霖 殷跃辉.焦虑与心房颤动相互作用的研究进展[J].心血管病学进展,2021,(2):123.[doi:10.16806/j.cnki.issn.1004-3934.2021.02.007]
　ZHAO Wei,CHEN Yunlin,YIN Yuehui.Interaction Between Anxiety and Atrial Fibrillation[J].Advances in Cardiovascular Diseases,2021,(12):123.[doi:10.16806/j.cnki.issn.1004-3934.2021.02.007]
[2]孙天恒?张疆华?汤宝鹏.植入式心律转复除颤器术后焦虑研究的进展[J].心血管病学进展,2023,(12):1069.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.004]
　SUN Tianheng,ZHANG Jianghua,TANG Baopeng.Advances in the Study of Postoperative Anxiety with?mplantable Cardioverter-Defibrillators[J].Advances in Cardiovascular Diseases,2023,(12):1069.[doi:10.16806/j.cnki.issn.1004-3934.2023.12.004]

备注/Memo

备注/Memo:
基金项目：北京市属医院科研培育计划项目（PX2020006）
 通信作者：陈晖，E-mail:chenhui72@medmail.com.cn?/span>
收稿日期：2021-05-14
更新日期/Last Update: 2022-01-07