[1]蓝庆肃 武锋超 马兰虎 韩冰 徐金 彭瑜 张钲.Mavacamten治疗肥厚型心肌病的研究进展[J].心血管病学进展,2021,(11):1028-1031.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
 LAN Qingsu,WU Fengchao,MA Lanhu,et al.Mavacamten in Treatment of Hypertrophic Cardiomyopathy[J].Advances in Cardiovascular Diseases,2021,(11):1028-1031.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
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Mavacamten治疗肥厚型心肌病的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年11期
页码:
1028-1031
栏目:
综述
出版日期:
2021-11-25

文章信息/Info

Title:
Mavacamten in Treatment of Hypertrophic Cardiomyopathy
文章编号:
202105034
作者:
蓝庆肃1 武锋超 1 马兰虎1 韩冰 123 徐金 1 彭瑜23 张钲23
(1.兰州大学第一临床医学院,甘肃 兰州 730000; 2.兰州大学第一医院心脏中心,甘肃 兰州 730000;3.甘肃省心血管疾病重点实验室,甘肃 兰州 730000)
Author(s):
LAN Qingsu1 WU Fengchao1MA Lanhu1HAN Bing123XU Jin1PENG Yu23ZHANG Zheng23
(1.The First Clinical Medical College,Lanzhou University,Lanzhou 730000,Gansu,China; 2.Heart Center,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China; 3.Key Laboratory of Cardiovascular Diseases of Gansu Province,Lanzhou 730000,Gansu,China)
关键词:
Mavacamten肥厚型心肌病肌球蛋白N末端脑钠肽前体
Keywords:
MavacamtenHypertrophic cardiomyopathyMyosinN-terminal pro-brain natriuretic peptide
DOI:
10.16806/j.cnki.issn.1004-3934.2021.11.000
摘要:
肥厚型心肌病是一种常见的遗传性心肌病,通常由编码肌节相关蛋白质的基因突变所引起,主要表现为劳力性呼吸困难、胸痛及晕厥等。肥厚型心肌病已报道半个多世纪,但在药物治疗上无较大的进展,直至肌球蛋白靶向抑制剂mavacamten的出现,为不同类型的肥厚型心肌病患者带来了曙光,是遗传性心肌病精准治疗的一大进步。现对国外有关mavacamten治疗肥厚型心肌病的研究进展进行综述。
Abstract:
Hypertrophic cardiomyopathy(HCM),a common hereditary cardiomyopathy,is usually caused by a mutation in a gene that codes for sarcomere related proteins. The main manifestations were exertional dyspnea,pectoralgia and syncope. HCM has been reported for more than half a century,but has not made great progress in drug therapy. Until the appearance of the myosin targeted inhibitor mavacamten,it brings the dawn for patients with different types of HCM,which is a great progress in the precise treatment of hereditary cardiomyopathy. In this article,we will summarize the foreign research on mavacamten in the treatment of HCM

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更新日期/Last Update: 2021-12-06