[1]臧童童 沈雳.基因多态性与心力衰竭发生和发展的研究进展[J].心血管病学进展,2021,(6):516.[doi:10.16806/j.cnki.issn.1004-3934.2021.06.010]
 ZANG TongtongSHEN Li.The Relationship Between Gene Polymorphism and Heart Failure[J].Advances in Cardiovascular Diseases,2021,(6):516.[doi:10.16806/j.cnki.issn.1004-3934.2021.06.010]
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基因多态性与心力衰竭发生和发展的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年6期
页码:
516
栏目:
综述
出版日期:
2021-06-25

文章信息/Info

Title:
The Relationship Between Gene Polymorphism and Heart Failure
作者:
臧童童 沈雳
(复旦大学附属中山医院心内科 上海市心血管病研究所,上海 200032)
Author(s):
ZANG TongtongSHEN Li
 (Department of Cardiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
关键词:
基因多态性单核酸多态性心力衰竭生物信息学
Keywords:
Gene polymorphismSingle nucleotide polymorphismHeart failureBioinformatics
DOI:
10.16806/j.cnki.issn.1004-3934.2021.06.010
摘要:
心力衰竭是一种复杂的临床综合征,发病率高,预后较差。主要是神经体液因子参与这一心功能障碍和心肌肥厚的过程,因此参与这一过程的基因的多态性有可能影响心力衰竭的诊断、治疗和预后。心力衰竭与多种基因多态性有关,主要是肾素-血管紧张素-醛固酮系统、交感-肾上腺髓质系统内皮素系统中涉及的基因回顾近年来已发表的论文以总结基因多态性与心力衰竭的诊断、治疗及预后的关系
Abstract:
Heart failure is a complicated clinical syndrome with high morbidity and poor prognosis. It is mainly neuro-humoral factors that are involved in the process of cardiac hypertrophy and cardiac dysfunction,so the gene polymorphism in this process may affect the diagnosis,treatment and prognosis of heart failure. Heart failure is associated with several gene polymorphisms,mainly involved in the renin-angiotensin-aldosterone system (RAAS),the sympathetic-adrenal medulla system,and the endothelin system. Some genes in the inflammatory response are also involved in the development of heart failure. This paper aims to review recent published papers to summarize the relationship between gene polymorphism and the diagnosis,treatment and prognosis of heart failure,providing ideas for individualized diagnosis and treatment of heart failure

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备注/Memo

备注/Memo:
收稿日期:2020-10-10基金项目:国家自然科学基金(81670319)
更新日期/Last Update: 2021-07-23