[1]杨晓倩 秦莉 张艺文 汪汉.苦参治疗新型冠状病毒感染合并心肌炎的网络药理学分析[J].心血管病学进展,2021,(6):566.[doi:10.16806/j.cnki.issn.1004-3934.2020.12.021]
　YANG Xiaoqian,QIN Li,ZHANG Yiwen,et al.Network Pharmacological Analysis of Sophora Flavescens on Novel Coronavirus Infection complicated with Myocarditis[J].Advances in Cardiovascular Diseases,2021,(6):566.[doi:10.16806/j.cnki.issn.1004-3934.2020.12.021]
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苦参治疗新型冠状病毒感染合并心肌炎的网络药理学分析()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年6期
页码:
566
栏目:
论著
出版日期:
2021-06-25

文章信息/Info

Title:
Network Pharmacological Analysis of Sophora Flavescens on Novel Coronavirus Infection complicated with Myocarditis
作者:
杨晓倩 秦莉 张艺文 汪汉
 (西南交通大学医学院 西南交通大学附属医院 成都市第三人民医院心内科,四川 成都 610031)
Author(s):
YANG Xiaoqian;  QIN Li;  ZHANG Yiwen;  WANG Han
(Department of Cardiology, The Third People’s Hospital of Chengdu, Southwest Jiaotong University Medical School, The Affiliated Hospital of Southwest Jiaotong University, Chengdu 610031, Sichuan, China)
关键词:
苦参; 新型冠状病毒; 心肌炎; 网络药理学
Keywords:
Sophora flavescens;  Novel coronavirus;  Myocarditis;  Network pharmacology
DOI:
10.16806/j.cnki.issn.1004-3934.2020.12.021
摘要:
目的 采用网络药理学方法探讨苦参治疗2019-nCoV感染合并心肌炎的活性成分及作用机制。方法 利用TCMSP数据库获得苦参的活性成分及其相关靶点，并在GeneCards数据库和OMIM数据库中查找2019-nCoV和心肌炎的靶点；使用R软件预测苦参作用于2019-nCoV感染合并病毒性心肌炎的作用靶点，并利用Cytoscape3.7.2软件构建“药物-活性成分-疾病-靶点”的网络；通过String数据库进行蛋白质相互作用分析，并筛选关键靶点；采用R软件进行GO功能富集分析和KEGG代谢通路富集分析。结果 筛选得到苦参作用于2019-nCov心肌炎的活性成分14个，作用靶点34个。富集分析显示，作用靶点主要涉及63个生物学功能和135条通路。结论 苦参可能通过多成分、多靶点和多通路的共同作用发挥抗2019-nCoV心肌炎的作用。
Abstract:
Objective To explore the active ingredient and underlying mechanism of Sophora Flavescens on novel coronavirus (2019-nCoV) complicated with myocarditis by using network pharmacology analysis. Methods The active ingredients and related targets of Sophora Flavescens were obtained from TCMSP database, and targets of 2019-nCoV and myocarditis searched in GeneCards and OMIM database. R software was used to predict the targets of 2019-nCoV with myocarditis, and Cytoscape to build a "drug-active ingredient-disease-target" network. Protein interaction was analyzed in String database with key targets screened, and KO functional enrichment and KEGG metabolic pathway enrichment analyzed with R software as well. Results 14 active ingredients and 34 targets of Sophora Flavescens on 2019-nCoV complicated with myocarditis were screened out. Results of enrichment analysis indicated these targets were mainly involved with 63 biological functions and 135 signaling pathways. Conclusion Sophora Flavescens may play a role in anti-2019-nCoV infection complicated with myocarditis through the joint action of multi-ingredients, multi-targets and multi-pathways

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备注/Memo

备注/Memo:
收稿日期：2020-03-06
更新日期/Last Update: 2021-07-23