[1]左海奇 孙鑫 田野.替格瑞洛与氯吡格雷抑制中性粒细胞减轻急性ST段抬高型心肌梗死患者冠状动脉血栓炎症的对比研究[J].心血管病学进展,2020,(5):537-541,562.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.023]
　ZUO Haiqi,SUN Xin,TIAN Ye.A Comparative Study of Effects of Ticagrelor and Clopidogrel on Neutrophils in Coronary Thrombosis in Patients with A cute ST-segment Elevation Myocardial Infarction[J].Advances in Cardiovascular Diseases,2020,(5):537-541,562.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.023]
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替格瑞洛与氯吡格雷抑制中性粒细胞减轻急性ST段抬高型心肌梗死患者冠状动脉血栓炎症的对比研究

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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年5期
页码:
537-541,562
栏目:
出版日期:
2020-05-25

文章信息/Info

Title:
A Comparative Study of Effects of Ticagrelor and Clopidogrel on Neutrophils in Coronary Thrombosis in Patients with A cute ST-segment Elevation Myocardial Infarction
作者:
左海奇 孙鑫 田野
（哈尔滨医科大学附属第一医院心血管内科,黑龙江 哈尔滨 150001)
Author(s):
ZUO Haiqi;  SUN Xin;  TIAN Ye
(Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China)?/html>
关键词:
急性心肌梗死; P2Y12受体拮抗剂; 血栓; 中性粒细胞; 中性粒细胞胞外诱捕网
Keywords:
Acute myocardial infarction;  P2Y12 receptor antagonist;  Thrombus;  Neutrophils;  Neutrophil extracellular traps
DOI:
10.16806/j.cnki.issn.1004-3934.2020.05.023
摘要:
目的 比较替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死患者中性粒细胞的影响从而减轻冠状动脉血栓炎症。方法 选取哈尔滨医科大学附属一院2016年5月—2017年3月行急诊经皮冠脉介入术的ST段抬高型心肌梗死患者，信封法随机分成替格瑞洛组（23例）和氯吡格雷组（24例），，比较两组冠状动脉血栓中中性粒细胞数量、髓过氧化物酶阳性细胞数量和冠状动脉血浆DNA-组蛋白/NETs的表达。结果 与氯吡格雷组相比，替格瑞洛组血栓中中性粒细胞、髓过氧化物酶阳性表达面积百分比分别减少45%[( 10.11% ± 6.16%) vs ( 18.23%± 7.26%), P < 0.01]、43%[(13 .38% ± 7.29%) vs (23 .57% ± 8.33%), P < 0.01]。两组术后2 4 h外周血中性粒细胞数量和冠状动脉血DNA-组蛋白/NETs表达均无统计学差异（ P>0.05）。结论 与氯吡格雷相比，替格瑞洛更显著减少冠状动脉血栓的中性粒细胞数量和髓过氧化物酶阳性细胞数量，从而减轻冠状动脉血栓炎症。
Abstract:
Objective This study was to compare the effects of ticagrelor and clopidogrel, which inhibited neutrophils in coronary thrombosis and reduced inflammation. Methods Patients with ST-segment elevation myocardial infarction who underwent emergency percutaneous coronary intervention in The First Affiliated Hospital of Harbin Medical University from May 2016 to March 2017 were randomly divided into two groups: ticagrelor group( n=23) and clopidogrel group(n=24). The number of neutrophils, myeloperoxidase positive cells and the expression of DNA- histone/NETs in coronary plasma were compared between the two groups. Results Compared with clopidogrel group, the percentage of thrombotic neutrophils and myeloperoxidase positive expression area in ticagrelor group decreased by 45%[(10.11%±6.16%) vs (18.23% ±7.26%), P<0.01] and 43%[(13.38%±7.29%) vs (23.57±8.33%), P<0.01] respectively. There was no significant difference in the number of peripheral blood neutrophils and the expression of DNA-histone/NETs in coronary artery blood between the two groups 24 hours after operation. Conclusion Compared with clopidogrel,ticagrelor significantly reduces the number of neutrophils and myeloperoxidase positive cells in coronary artery thrombosis, thus alleviating coronary artery thrombosis.

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更新日期/Last Update: 2020-08-12