[1]张依格 常盼 王西辉 王建榜.细胞焦亡在心血管疾病中的作用进展[J].心血管病学进展,2020,(7):724-728.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.013]
 ZHANG Yige,CHANG Pan,WANG Xihui,et al.Role of Pyroptosis in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2020,(7):724-728.[doi:10.16806/j.cnki.issn.1004-3934.2020.07.013]
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细胞焦亡在心血管疾病中的作用进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年7期
页码:
724-728
栏目:
出版日期:
2020-07-25

文章信息/Info

Title:
Role of Pyroptosis in Cardiovascular Disease
作者:
张依格 常盼 王西辉 王建榜
(西安医学院第二附属医院心内科暨陕西省心血管内科疾病临床研究分中心,陕西 西安710038)
Author(s):
ZHANG YigeCHANG PanWANG XihuiWANG Jianbang
(DepartmentofCardiology,The Second Affiliated Hospital of Xi’an Medical University, ,Xian 710038, Shaanxi,China)
关键词:
细胞焦亡炎症小体半胱天冬酶Gasdermin D蛋白心血管疾病
Keywords:
Pyroptosis Inflammasome Caspase Gasdermin D Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2020.07.013
摘要:
细胞焦亡是一种新近发现的、依赖炎性半胱天冬酶-1/4/5/11的程序性细胞死亡方式,主要通过Gasdermin D蛋白的活化,介导细胞膜形成孔洞直至细胞溶解的过程,并伴随有大量细胞内容物的释放,其中包括促炎因子白介素-1β和白介素-18等。近来研究表明,细胞焦亡在心血管疾病的病理生理过程中发挥着重要作用。总结细胞焦亡在心血管疾病中的作用及最新研究进展,或许可为心血管疾病的防治提供新的靶点和思路。
Abstract:
Pyroptosis is a new-found programmed cell death that depends on inflammatory caspase-1/4/5/11. Through the activation of gasdermin-D protein, it mediates the formation of cell membrane pores until the cytolysis occurs. This process is accompanied by the release of a large number of cellular contents , including the pro-inflammatory factors IL-1β and IL-18. Recent studies have shown that pyroptosis plays an important role in the pathophysiology of cardiovascular disease. To investigate the role of pyroptosis in cardiovascular disease and the latest research progress may provide new targets and ideas for the prevention and treatment of cardiovascular disease.

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备注/Memo

备注/Memo:
基金项目:陕西省科学技术厅课题(2018SF-114)
更新日期/Last Update: 2020-10-09